Maribel Soto-Nava
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View article: Expression of CX3CL1 in the neoplastic lung tissue of squamous cell lung cancer
Expression of CX3CL1 in the neoplastic lung tissue of squamous cell lung cancer Open
Lung cancer has one of the highest mortality rates. Although epidermoid lung cancer is one of the most prevalent subtypes of lung cancer, no targeted therapy is currently available for this type of cancer. CX3CL1 is a chemokine that has em…
View article: Mapping early PRC2 nucleation sites upon Suz12 reintroduction reveals features of <i>de novo</i> Polycomb recruitment
Mapping early PRC2 nucleation sites upon Suz12 reintroduction reveals features of <i>de novo</i> Polycomb recruitment Open
Polycomb domains safeguard cell identity by maintaining lineage-specific chromatin states enriched in repressive histone modifications, preserving the epigenetic memory of cell lineages. While Polycomb Repressive Complex 2 (PRC2) can re-es…
View article: Phenotypic and transcriptomic similarity between the N2 Ancestral and a tropical wild isolate of <i>C. elegans</i> reveals divergence from the reference Bristol strain
Phenotypic and transcriptomic similarity between the N2 Ancestral and a tropical wild isolate of <i>C. elegans</i> reveals divergence from the reference Bristol strain Open
In recent years, the scientific community has increasingly recognized the importance of incorporating ecologically relevant perspectives into laboratory research. In the case of the free-living nematode Caenorhabditis elegans , numerous st…
View article: Zinc and selenium supplementation on treated HIV-infected individuals induces changes in body composition and on the expression of genes responsible of naïve CD8+ T cells function
Zinc and selenium supplementation on treated HIV-infected individuals induces changes in body composition and on the expression of genes responsible of naïve CD8+ T cells function Open
Background and aim Deficiency of zinc and selenium is common in persons living with human immunodeficiency virus (PLWHIV) and has been associated with the development of non-AIDS related comorbidities, impaired immune system function and m…
View article: Transcriptomic Analysis Reveals Early Alterations Associated with Intrinsic Resistance to Targeted Therapy in Lung Adenocarcinoma Cell Lines
Transcriptomic Analysis Reveals Early Alterations Associated with Intrinsic Resistance to Targeted Therapy in Lung Adenocarcinoma Cell Lines Open
Lung adenocarcinoma is the most prevalent form of lung cancer, and drug resistance poses a significant obstacle in its treatment. This study aimed to investigate the overexpression of long non-coding RNAs (lncRNAs) as a mechanism that prom…
View article: Reversal of high-glucose–induced transcriptional and epigenetic memories through NRF2 pathway activation
Reversal of high-glucose–induced transcriptional and epigenetic memories through NRF2 pathway activation Open
Diabetes complications such as nephropathy, retinopathy, or cardiovascular disease arise from vascular dysfunction. In this context, it has been observed that past hyperglycemic events can induce long-lasting alterations, a phenomenon term…
View article: Unveiling ecological/evolutionary insights in HIV viral load dynamics: Allowing random slopes to observe correlational changes to CpG-contents and other molecular and clinical predictors
Unveiling ecological/evolutionary insights in HIV viral load dynamics: Allowing random slopes to observe correlational changes to CpG-contents and other molecular and clinical predictors Open
In the context of infectious diseases, the dynamic interplay between ever-changing host populations and viral biology demands a more flexible modeling approach than common fixed correlations. Embracing random-effects regression models allo…
View article: Transcriptomic Analysis Reveals Early Alterations Associated with Intrinsic Resistance to Target Therapy in Lung Adenocarcinoma Cell Lines
Transcriptomic Analysis Reveals Early Alterations Associated with Intrinsic Resistance to Target Therapy in Lung Adenocarcinoma Cell Lines Open
Lung adenocarcinoma is the most prevalent form of lung cancer, and drug resistance is a significant obstacle in its treatment. This study aimed to investigate the overexpression of long non-coding RNAs (lncRNAs) as a mechanism that promote…
View article: SARSCoV-2 antibody prevalence and titers in persons living with HIV cared for at a large tertiary reference center in Mexico City
SARSCoV-2 antibody prevalence and titers in persons living with HIV cared for at a large tertiary reference center in Mexico City Open
Objective To assess SARS-CoV-2 antibody prevalence and titers in people living with HIV (PLWHIV) on antiretroviral treatment (ART) enrolled at a tertiary reference hospital in Mexico. Methods Two plasma aliquots per person, used for HIV vi…
View article: Honduras HIV cohort: HLA class I and CCR5-Δ32 profiles and their associations with HIV disease outcome
Honduras HIV cohort: HLA class I and CCR5-Δ32 profiles and their associations with HIV disease outcome Open
Human leukocyte antigen (HLA) polymorphisms represent the strongest genetic modifier of HIV disease progression. Diverse HLA distributions can lead to distinct HIV control landscapes at the population level. We aimed to describe HLA allele…
View article: Transcriptional signature of early cisplatin drug-tolerant persister cells in lung adenocarcinoma
Transcriptional signature of early cisplatin drug-tolerant persister cells in lung adenocarcinoma Open
Resistance to cisplatin is the main cause of treatment failure in lung adenocarcinoma. Drug-tolerant-persister (DTP) cells are responsible for intrinsic resistance, since they survive the initial cycles of treatment, representing a reservo…
View article: NRF2 pathway activation reverts high-glucose-induced transcriptional memory in endothelial cells
NRF2 pathway activation reverts high-glucose-induced transcriptional memory in endothelial cells Open
Various diabetes complications, including nephropathy, retinopathy, and cardiovascular disease, arise from vascular dysfunction. In this context, it has been observed that past hyperglycaemic events can induce long-lasting transcriptional …
View article: PrEPvenir la infección por VIH
PrEPvenir la infección por VIH Open
Esta infografía busca extender la información sobre las nuevas estrategias para prevenir la infección por el Virus de la Inmunodeficiencia Humana (vih), y así reducir el número de nuevas infecciones a nivel mundial. Se habla del tratamient…
View article: Longitudinal Characterization of a Neutralizing and Total Antibody Response in Patients with Severe COVID-19 and Fatal Outcomes
Longitudinal Characterization of a Neutralizing and Total Antibody Response in Patients with Severe COVID-19 and Fatal Outcomes Open
The host immune response to SARS-CoV-2 appears to play a critical role in disease pathogenesis and clinical manifestations in severe COVID-19 cases. Until now, the importance of developing a neutralizing antibody response in the acute phas…
View article: Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population
Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population Open
The majority of studies on SARS-CoV-2 vaccine-elicited immunity and immune evasion have focused on single vaccines corresponding to those distributed in high-income countries. However, in low- and middle-income countries, vaccine deploymen…
View article: Seroepidemiology of SARS-CoV-2 in healthcare personnel working at the largest tertiary COVID-19 referral hospitals in Mexico City
Seroepidemiology of SARS-CoV-2 in healthcare personnel working at the largest tertiary COVID-19 referral hospitals in Mexico City Open
Introduction We performed a longitudinal SARS-CoV-2 seroepidemiological study in healthcare personnel of the two largest tertiary COVID-19 referral hospitals in Mexico City. Methods All healthcare personnel, including staff physicians, phy…
View article: Antibody and memory B-cell immunity in a heterogeneously SARS-CoV-2 infected and vaccinated population
Antibody and memory B-cell immunity in a heterogeneously SARS-CoV-2 infected and vaccinated population Open
Global population immunity to SARS-CoV-2 is accumulating through heterogenous combinations of infection and vaccination. Vaccine distribution in low- and middle-income countries has been variable and reliant on diverse vaccine platforms. W…
View article: Rapid, Near Point-of-Care Assay for HLA-B*57:01 Genotype Associated with Severe Hypersensitivity Reaction to Abacavir
Rapid, Near Point-of-Care Assay for HLA-B*57:01 Genotype Associated with Severe Hypersensitivity Reaction to Abacavir Open
Objective The nucleoside reverse transcriptase inhibitor abacavir is commonly used to treat young children with HIV infection. Abacavir can trigger a severe hypersensitivity reaction in people who are homozygous or heterozygous for HLA-B*5…
View article: Seroepidemiology of SARS-CoV-2 in Healthcare Personnel Working at the Largest Tertiary COVID-19 Referral Hospitals in Mexico City
Seroepidemiology of SARS-CoV-2 in Healthcare Personnel Working at the Largest Tertiary COVID-19 Referral Hospitals in Mexico City Open
View article: Near point-of-care, point-mutation test to detect drug resistance in HIV-1: a validation study in a Mexican cohort
Near point-of-care, point-mutation test to detect drug resistance in HIV-1: a validation study in a Mexican cohort Open
Objective: Pretreatment HIV-drug resistance (PDR, HIVDR) to non-nucleoside reverse transcriptase inhibitors (NNRTIs) is increasing globally. NNRTIs continue to be used as first-line antiretroviral therapy (ART) in some communities due to t…
View article: Novel HLA class I associations with HIV-1 control in a unique genetically admixed population
Novel HLA class I associations with HIV-1 control in a unique genetically admixed population Open
View article: Weaker HLA Footprints on HIV in the Unique and Highly Genetically Admixed Host Population of Mexico
Weaker HLA Footprints on HIV in the Unique and Highly Genetically Admixed Host Population of Mexico Open
HIV circumvents HLA class I-restricted CD8 + T-cell responses through selection of escape mutations that leave characteristic mutational “footprints,” also known as HLA-associated polymorphisms (HAPs), on HIV sequences at the population le…
View article: In vitro functional assessment of natural HIV-1 group M Vpu sequences using a universal priming approach
In vitro functional assessment of natural HIV-1 group M Vpu sequences using a universal priming approach Open
The HIV-1 accessory protein Vpu exhibits high inter- and intra- subtype genetic diversity that may influence Vpu function and possibly contribute to HIV-1 pathogenesis. However, scalable methods to evaluate genotype/phenotype relationships…