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View article: Childhood adverse events and BDNF promoter methylation in later-life
Childhood adverse events and BDNF promoter methylation in later-life Open
Studies have shown that the effects of early-life stress and trauma can be enduring, with long-term negative effects on health. Epigenetics, including DNA methylation, have been implicated as a potential mechanism for these effects. Brain-…
View article: Sex differences in dementia risk and risk factors: Individual‐participant data analysis using 21 cohorts across six continents from the COSMIC consortium
Sex differences in dementia risk and risk factors: Individual‐participant data analysis using 21 cohorts across six continents from the COSMIC consortium Open
Introduction Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno‐regional groups. Methods A total of 29,850 participants (58% women) from 21 cohorts across six continents…
View article: Brain‐derived neurotrophic factor (<scp><i>BDNF</i>)</scp> variants and promoter I methylation are associated with prolonged nocturnal awakenings in older adults
Brain‐derived neurotrophic factor (<span><i>BDNF</i>)</span> variants and promoter I methylation are associated with prolonged nocturnal awakenings in older adults Open
Summary Brain‐derived neurotrophic factor (BDNF) is important for sleep physiology. This study investigates whether BDNF variants and promoter I methylation may be implicated in sleep disturbances in older adults. Genotyping was performed …
View article: Objectively Assessed Weight Change and All-Cause Mortality among Community-Dwelling Older People
Objectively Assessed Weight Change and All-Cause Mortality among Community-Dwelling Older People Open
Later life changes in body weight may be associated with an increased risk of mortality in older adults. The objective of this study was to examine whether weight change over four years was associated with a 17-year mortality risk in older…
View article: The Association of Weight Loss, Weight Status, and Abdominal Obesity with All-Cause Mortality in Older Adults
The Association of Weight Loss, Weight Status, and Abdominal Obesity with All-Cause Mortality in Older Adults Open
Objectives: The objectives of this study were to examine whether weight loss, weight status (based on body mass index [BMI] categories), and abdominal obesity (based on waist circumference [WC]) were associated with a 17-year…
View article: Steroid 21-hydroxylase gene variants and late-life depression
Steroid 21-hydroxylase gene variants and late-life depression Open
View article: Structural brain alterations in older adults exposed to early-life adversity
Structural brain alterations in older adults exposed to early-life adversity Open
View article: Time-dependent depression and anxiety symptoms as risk factors for recurrent cardiac events: findings from the UPBEAT-UK study
Time-dependent depression and anxiety symptoms as risk factors for recurrent cardiac events: findings from the UPBEAT-UK study Open
Background Depression is a well-known risk factor for recurrent cardiac events (RCEs) but findings are less consistent for anxiety, not previously reported on using a time-dependent approach. We aimed to study the prognostic effect of anxi…
View article: 11β-Hydroxylase (<i>CYP11B1</i>) gene variants and new-onset depression in later life
11β-Hydroxylase (<i>CYP11B1</i>) gene variants and new-onset depression in later life Open
Background Cumulative exposure to high glucocorticoid levels is detrimental for the brain and may have particular implications in later life. A feature of late-life depression is increased cortisol secretion. Variants in the CYP11B1 gene, …
View article: Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study
Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study Open
View article: The long-term consequences of trauma and posttraumatic stress disorder symptoms on later life cognitive function and dementia risk
The long-term consequences of trauma and posttraumatic stress disorder symptoms on later life cognitive function and dementia risk Open
View article: A cross‐national study of depression in preclinical dementia: A COSMIC collaboration study
A cross‐national study of depression in preclinical dementia: A COSMIC collaboration study Open
Introduction Depression commonly accompanies Alzheimer's disease, but the nature of this association remains uncertain. Methods Longitudinal data from the COSMIC consortium were harmonized for eight population‐based cohorts from four conti…
View article: Does parity matter in women’s risk of dementia? A COSMIC collaboration cohort study
Does parity matter in women’s risk of dementia? A COSMIC collaboration cohort study Open
Background Dementia shows sex difference in its epidemiology. Childbirth, a distinctive experience of women, is associated with the risk for various diseases. However, its association with the risk of dementia in women has rarely been stud…
View article: Testosterone Level and Cause-Specific Mortality in Older Men without Metabolic Syndrome
Testosterone Level and Cause-Specific Mortality in Older Men without Metabolic Syndrome Open
Our data suggest that the association of testosterone with mortality in men without metabolic syndrome might be differential according to the cause of death. These findings may partially explain the heterogeneity across studies on the rela…
View article: Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: A COSMIC study
Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: A COSMIC study Open
Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer`s disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across internationa…
View article: Structural brain changes with lifetime trauma and re-experiencing symptoms is <i>5-HTTLPR</i> genotype-dependent
Structural brain changes with lifetime trauma and re-experiencing symptoms is <i>5-HTTLPR</i> genotype-dependent Open
Background: Findings on structural brain alterations following trauma are inconsistent due probably to heterogeneity in imaging studies and population, clinical presentations, genetic vulnerability, and selection of controls. This s…
View article: Time-dependent cognitive and somatic symptoms of depression as predictors of new cardiac-related events in at-risk patients: the UPBEAT-UK cohort
Time-dependent cognitive and somatic symptoms of depression as predictors of new cardiac-related events in at-risk patients: the UPBEAT-UK cohort Open
Background Evidence suggests that somatic rather than cognitive depressive symptoms are risk factors for recurrent cardiac events in at-risk patients. However, this has never been explored using a time-dependent approach in a narrow time-f…
View article: Is Peripheral <i>BDNF</i> Promoter Methylation a Preclinical Biomarker of Dementia?
Is Peripheral <i>BDNF</i> Promoter Methylation a Preclinical Biomarker of Dementia? Open
Brain-derived neurotrophic factor (BDNF) has been implicated in dementia. Preliminary evidence suggests that BDNF DNA methylation may be a diagnostic biomarker of dementia, but the potential pre-clinical utility remains unclear. Participan…
View article: Sex-specific depressive symptoms as markers of pre-Alzheimer dementia: findings from the Three-City cohort study
Sex-specific depressive symptoms as markers of pre-Alzheimer dementia: findings from the Three-City cohort study Open
View article: The extent to which childhood adversity and recent stress influence all-cause mortality risk in older adults
The extent to which childhood adversity and recent stress influence all-cause mortality risk in older adults Open
View article: Determinants of cognitive performance and decline in 20 diverse ethno-regional groups: A COSMIC collaboration cohort study
Determinants of cognitive performance and decline in 20 diverse ethno-regional groups: A COSMIC collaboration cohort study Open
BACKGROUND: With no effective treatments for cognitive decline or dementia, improving the evidence base for modifiable risk factors is a research priority. This study investigated associations between risk factors and late-life cognitive d…
View article: P4‐414: LIFESTYLE AND CARDIOVASCULAR RISK FACTOR CLUSTERS AND COGNITIVE DECLINE
P4‐414: LIFESTYLE AND CARDIOVASCULAR RISK FACTOR CLUSTERS AND COGNITIVE DECLINE Open
Modifiable risk factors for cognitive decline are well established. However, to date, the literature has typically focused on the relationship between individual risk factors and later cognitive outcome. Despite this, we know that risk fac…
View article: P2‐544: RELATIONSHIP BETWEEN EDUCATION, APOLIPOPROTEIN EPSILON 4 (<i>APOE*4</i>) AND COGNITIVE IMPAIRMENT IN DIVERSE ETHNO‐REGIONAL GROUPS: THE COSMIC COLLABORATION
P2‐544: RELATIONSHIP BETWEEN EDUCATION, APOLIPOPROTEIN EPSILON 4 (<i>APOE*4</i>) AND COGNITIVE IMPAIRMENT IN DIVERSE ETHNO‐REGIONAL GROUPS: THE COSMIC COLLABORATION Open
Greater years of education are associated with a lower incidence of dementia and reduced magnitude of cognitive decline in late adulthood. Unclear is whether this association is linear or nonlinear, and whether there is a threshold level o…
View article: Genetic and Epigenetic Regulation of the Serotonin Transporter Gene in Late-Life Depression
Genetic and Epigenetic Regulation of the Serotonin Transporter Gene in Late-Life Depression Open
Recently we published research that investigated epigenetic regulation of the serotonin transporter gene (SLC6A4) in peripheral blood and genetic variation in late-life depression 1 .We found that functional SLC6A4 genetic variation intera…
View article: Variations in reproductive events across life: a pooled analysis of data from 505 147 women across 10 countries
Variations in reproductive events across life: a pooled analysis of data from 505 147 women across 10 countries Open
STUDY QUESTION How has the timing of women’s reproductive events (including ages at menarche, first birth, and natural menopause, and the number of children) changed across birth years, racial/ethnic groups and educational levels? SUMMARY …
View article: Lifetime major depression and grey-matter volume
Lifetime major depression and grey-matter volume Open
Background: There is evidence of structural brain alterations in major depressive disorder (MDD), but little is known about how these alterations might be affected by age at onset or genetic vulnerability. This study examines whether lifet…
View article: Increased Serum C-reactive Protein and Corpus Callosum Alterations in Older Adults
Increased Serum C-reactive Protein and Corpus Callosum Alterations in Older Adults Open
Chronic systemic low-grade inflammation is associated with aging, but little is known on whether age-related inflammation affects brain structure, particularly white matter. The current study tested the hypothesis that in older adults with…
View article: Relationships between intensity, duration, cumulative dose, and timing of smoking with age at menopause: A pooled analysis of individual data from 17 observational studies
Relationships between intensity, duration, cumulative dose, and timing of smoking with age at menopause: A pooled analysis of individual data from 17 observational studies Open
The probability of earlier menopause is positively associated with intensity, duration, cumulative dose, and earlier initiation of smoking. Smoking duration is a much stronger predictor of premature and early menopause than others. Our fin…
View article: Association between DNA methylation of the <i>KITLG</i> gene and cortisol levels under stress: a replication study
Association between DNA methylation of the <i>KITLG</i> gene and cortisol levels under stress: a replication study Open
A recent study reported for the first time, that DNA methylation of the KITLG gene mediates the association between childhood trauma and cortisol stress reactivity. Our study aimed to provide the first independent replication of these find…
View article: Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression
Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression Open