Marie‐Cécile Nierat
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View article: Validity and reliability of anharmonic morphological ventilometry for the characterisation of human breathing
Validity and reliability of anharmonic morphological ventilometry for the characterisation of human breathing Open
Diagnosing and monitoring respiratory disorders typically rely on pulmonary function testing, which requires full patient cooperation and trained personnel, limiting its applicability. Analysing natural breathing offers a valuable alternat…
View article: Non-zero risk of adverse psychological reactions induced by experimental dyspnoea studies in healthy volunteers: possible ethical implications
Non-zero risk of adverse psychological reactions induced by experimental dyspnoea studies in healthy volunteers: possible ethical implications Open
Background Experimentally inducing dyspnoea in healthy volunteers is a powerful research tool. Even though this approach is not considered to carry particular risks, dyspnoea occurs in a general context of stress. We hypothesised that expe…
View article: Contribution and evolution of respiratory muscles function in weaning outcome of ventilator-dependent patients
Contribution and evolution of respiratory muscles function in weaning outcome of ventilator-dependent patients Open
View article: Empathetic solicitude attenuates the affective and sensory dimensions of <scp> CO <sub>2</sub> </scp> ‐induced dyspnea: A randomized parallel arm experimental trial in healthy humans
Empathetic solicitude attenuates the affective and sensory dimensions of <span> CO <sub>2</sub> </span> ‐induced dyspnea: A randomized parallel arm experimental trial in healthy humans Open
Dyspnea testifies to profound suffering in patients and its relief is a priority for caregivers. This can be achieved by correcting causative disorders (“etiopathogenic” approach) or targeting the dyspnea itself (“symptomatic” approach), a…
View article: Medical hypnosis mitigates laboratory dyspnoea in healthy humans: a randomised, controlled experimental trial
Medical hypnosis mitigates laboratory dyspnoea in healthy humans: a randomised, controlled experimental trial Open
Question Dyspnoea persisting despite treatments of underlying causes requires symptomatic approaches. Medical hypnosis could provide relief without the untoward effects of pharmacological approaches. We addressed this question through expe…
View article: Airborne ultrasound for the contactless mapping of surface thoracic vibrations during human vocalizations: A pilot study
Airborne ultrasound for the contactless mapping of surface thoracic vibrations during human vocalizations: A pilot study Open
Physical examination of the thorax is key to the clinical diagnosis of respiratory diseases. Among other examination techniques, palpation evaluates the transmission of high-frequency vibrations produced by vocalizations (tactile fremitus)…
View article: Neurophysiological basis of respiratory discomfort improvement by mandibular advancement in awake OSA patients
Neurophysiological basis of respiratory discomfort improvement by mandibular advancement in awake OSA patients Open
Patients with obstructive sleep apneas (OSA) do not complain from dyspnea during resting breathing. Placement of a mandibular advancement device (MAD) can lead to a sense of improved respiratory comfort (“pseudo‐relief”) ascribed to a habi…
View article: High-frequency rTMS over cortical motor areas does not alleviate experimental dyspnea: A randomized sham-controlled study
High-frequency rTMS over cortical motor areas does not alleviate experimental dyspnea: A randomized sham-controlled study Open
View article: Interventions Relieving Dyspnea in Intubated Patients Show Responsiveness of the Mechanical Ventilation–Respiratory Distress Observation Scale
Interventions Relieving Dyspnea in Intubated Patients Show Responsiveness of the Mechanical Ventilation–Respiratory Distress Observation Scale Open
Rationale: Breathing difficulties are highly stressful. In critically ill patients, they are associated with an increased risk of posttraumatic manifestations. Dyspnea, the corresponding symptom, cannot be directly assessed in nonco…
View article: Short-term cognitive loading deteriorates breathing pattern and gas exchange in adult patients with congenital central hypoventilation syndrome
Short-term cognitive loading deteriorates breathing pattern and gas exchange in adult patients with congenital central hypoventilation syndrome Open
Question Human PHOX2B mutations result in life-threatening sleep-related hypoventilation (congenital central hypoventilation syndrome, CCHS). Most patients retain ventilatory activity when awake through a respiratory-related cortical netwo…
View article: ‘<i>Involve me and I learn</i>’: an experiential teaching approach to improve dyspnea awareness in medical residents
‘<i>Involve me and I learn</i>’: an experiential teaching approach to improve dyspnea awareness in medical residents Open
This study suggests that, in advanced medical residents, the personal discovery of dyspnea can have a positive impact on the understanding of what dyspnea represents for patients. This could help fight dyspnea invisibility.
View article: Respiratory distress observation scales to predict weaning outcome
Respiratory distress observation scales to predict weaning outcome Open
View article: Proportional assist ventilation relieves clinically significant dyspnea in critically ill ventilated patients
Proportional assist ventilation relieves clinically significant dyspnea in critically ill ventilated patients Open
Introduction Dyspnea is common and often severe symptom in mechanically ventilated patients. Proportional assist ventilation (PAV) is an assist ventilatory mode that adjusts the level of assistance to the activity of respiratory muscles. W…
View article: Conscious processing of narrative stimuli synchronizes heart rate between individuals
Conscious processing of narrative stimuli synchronizes heart rate between individuals Open
Heart rate has natural fluctuations that are typically ascribed to autonomic function. Recent evidence suggests that conscious processing can affect the timing of the heartbeat. We hypothesized that heart rate is modulated by conscious pro…
View article: Reply to ‘Letter to the editor: is maximal diaphragm tissue velocity suited for the assessment of diaphragm contractility?’
Reply to ‘Letter to the editor: is maximal diaphragm tissue velocity suited for the assessment of diaphragm contractility?’ Open
We appreciate the opportunity given to respond to Dr Beltrami's Letter (Beltrami 2021) regarding our recent publication (Poulard et al. 2020) in The Journal of Physiology. Below, we have paraphrased the main criticisms, each followed by ou…
View article: Respiratory Monitoring Based on Tracheal Sounds: Continuous Time-Frequency Processing of the Phonospirogram Combined with Phonocardiogram-Derived Respiration
Respiratory Monitoring Based on Tracheal Sounds: Continuous Time-Frequency Processing of the Phonospirogram Combined with Phonocardiogram-Derived Respiration Open
Patients with central respiratory paralysis can benefit from diaphragm pacing to restore respiratory function. However, it would be important to develop a continuous respiratory monitoring method to alert on apnea occurrence, in order to i…
View article: Ultrasound shear wave elastography for assessing diaphragm function in mechanically ventilated patients: a breath-by-breath analysis
Ultrasound shear wave elastography for assessing diaphragm function in mechanically ventilated patients: a breath-by-breath analysis Open
View article: Ultrafast ultrasound coupled with cervical magnetic stimulation for non‐invasive and non‐volitional assessment of diaphragm contractility
Ultrafast ultrasound coupled with cervical magnetic stimulation for non‐invasive and non‐volitional assessment of diaphragm contractility Open
Key points Twitch transdiaphragmatic pressure elicited by cervical magnetic stimulation of the phrenic nerves is a fully non‐volitional method for assessing diaphragm contractility in humans, yet it requires invasive procedures such as oes…
View article: Ultrafast Ultrasound Plane Wave Imaging As a Novel non-Invasive Technique to Assess Diaphragm Contractility in Response to Phrenic Nerve Magnetic Stimulation
Ultrafast Ultrasound Plane Wave Imaging As a Novel non-Invasive Technique to Assess Diaphragm Contractility in Response to Phrenic Nerve Magnetic Stimulation Open
International audience
View article: Conscious processing of narrative stimuli synchronizes heart rate between individuals
Conscious processing of narrative stimuli synchronizes heart rate between individuals Open
Heart rate has natural fluctuations that are typically ascribed to autonomic function. Recent evidence suggests that conscious processing can affect the timing of the heartbeat. We hypothesized that heart rate is modulated by conscious pro…
View article: Feasibility and Validity of an Observational Scale as a Surrogate of Dyspnea in Non-Communicating Intubated Patients in the Intensive Care Unit: The Mechanical Ventilation - Respiratory Distress Observation Scale
Feasibility and Validity of an Observational Scale as a Surrogate of Dyspnea in Non-Communicating Intubated Patients in the Intensive Care Unit: The Mechanical Ventilation - Respiratory Distress Observation Scale Open
View article: Decreased respiratory-related postural perturbations at the cervical level under cognitive load
Decreased respiratory-related postural perturbations at the cervical level under cognitive load Open
View article: Validation of melomind™ signal quality: a proof of concept resting-state and ERPs study
Validation of melomind™ signal quality: a proof of concept resting-state and ERPs study Open
Wearable EEG systems have become accessible to researchers and clinicians over the last decade, thus requiring neurotechnology companies to seek for outstanding EEG signal quality. Here, we show that the melomind™ headset equipped with dry…
View article: Additional file 2 of Ultrasound shear wave elastography for assessing diaphragm function in mechanically ventilated patients: a breath-by-breath analysis
Additional file 2 of Ultrasound shear wave elastography for assessing diaphragm function in mechanically ventilated patients: a breath-by-breath analysis Open
Additional file 2. Figure S2: Individual correlation coefficients between changes in transdiaphragmatic pressure (ΔPdi) and changes in diaphragm shear modulus (SMdi) can be found at the following link: https://figshare.com/s/c0f06ddf34d5a7…
View article: Postural preinspiratory cortical activity, genioglossus activity and fluid shift in awake obstructive sleep apnoea patients
Postural preinspiratory cortical activity, genioglossus activity and fluid shift in awake obstructive sleep apnoea patients Open
New Finding What is the central question of this study? Transition to supine posture induces an inspiratory load associated with cortical activation in awake healthy subjects. Some obstructive sleep apnoea patients exhibit this cortical ac…
View article: Ultrasound shear wave elastography for assessing diaphragm function within the intensive care unit
Ultrasound shear wave elastography for assessing diaphragm function within the intensive care unit Open
International audience
View article: Implanted Phrenic Stimulation Impairs Local Diaphragm Myofiber Reinnervation in Amyotrophic Lateral Sclerosis
Implanted Phrenic Stimulation Impairs Local Diaphragm Myofiber Reinnervation in Amyotrophic Lateral Sclerosis Open
International audience
View article: Physiological Validation of an Airborne Ultrasound Based Surface Motion Camera for a Contactless Characterization of Breathing Pattern in Humans
Physiological Validation of an Airborne Ultrasound Based Surface Motion Camera for a Contactless Characterization of Breathing Pattern in Humans Open
Characterizing the breathing pattern in naturally breathing humans brings important information on respiratory mechanics, respiratory muscle, and breathing control. However, measuring breathing modifies breathing (observer effect) through …
View article: Postural respiratory‐related cortical activation and rostral fluid shift in awake healthy humans
Postural respiratory‐related cortical activation and rostral fluid shift in awake healthy humans Open
New Findings What is the central question of this study? Moving to supine induces upper airway modifications and a fluid shift to the neck, which represent inspiratory load that predisposes to upper airway collapse. Is there cortical parti…
View article: Human diaphragm atrophy in amyotrophic lateral sclerosis is not predicted by routine respiratory measures
Human diaphragm atrophy in amyotrophic lateral sclerosis is not predicted by routine respiratory measures Open
Amyotrophic lateral sclerosis (ALS) patients show progressive respiratory muscle weakness leading to death from respiratory failure. However, there are no data on diaphragm histological changes in ALS patients and how they correlate with r…