Marie-Cécile Ploy
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View article: The bacterial SOS response promotes the expression of the transposase encoded by IS <i>CR</i> mobile genetic elements
The bacterial SOS response promotes the expression of the transposase encoded by IS <i>CR</i> mobile genetic elements Open
Insertion sequences (IS) are widely involved in bacterial genomic plasticity by disrupting, adding, moving genomic sequences, or by activating or extinguishing gene expression. A specific family of IS, IS CR (for insertion sequence of Comm…
View article: Dual regulatory role of IS91-encoded Orf121 in IS91 transposition
Dual regulatory role of IS91-encoded Orf121 in IS91 transposition Open
Insertion sequences (IS) are key players in bacterial genome plasticity and horizontal gene transfer. IS 91 , belonging to the HUH superfamily of single-strand nucleases, is often linked with antibiotic resistance genes. Besides the transp…
View article: Longitudinal three-year comparative genomic analysis of Pseudomonas aeruginosa respiratory isolates from mechanically ventilated intensive care unit patients
Longitudinal three-year comparative genomic analysis of Pseudomonas aeruginosa respiratory isolates from mechanically ventilated intensive care unit patients Open
Background: Pseudomonas aeruginosa is a common pathogen involved in ventilator-associated pneumonia (VAP) in intensive care unit (ICU) patients. Our primary objective was to characterize and compare the genomes of consecutive P. aeruginosa…
View article: Wastewater-based AMR surveillance associated with tourism on a Caribbean island (Guadeloupe)
Wastewater-based AMR surveillance associated with tourism on a Caribbean island (Guadeloupe) Open
View article: EU-JAMRAI – L’Europe engagée sur une réponse coordonnée et « une seule santé » pour faire face à l’antibiorésistance
EU-JAMRAI – L’Europe engagée sur une réponse coordonnée et « une seule santé » pour faire face à l’antibiorésistance Open
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View article: Dual regulatory role of IS<i>91</i>-encoded Orf121 in IS<i>91</i> transposition
Dual regulatory role of IS<i>91</i>-encoded Orf121 in IS<i>91</i> transposition Open
Prokaryotic insertion sequences (IS) are pivotal in the propagation of bacterial multidrug resistance, with IS 91 notably linked to virulence and antibiotic resistance genes. However, the precise mechanism by which IS 91 contributes to gen…
View article: Pneumococcal Septic Arthritis among Adults, France, 2010–2018
Pneumococcal Septic Arthritis among Adults, France, 2010–2018 Open
Streptococcus pneumoniae infection is considered an uncommon cause of arthritis in adults. To determine the clinical and microbiological characteristics of pneumococcal septic arthritis, we retrospectively studied a large series of cases a…
View article: <i>Emayella augustorita</i>, New Member of Pasteurellaceae, Isolated from Blood Cultures of Septic Patient
<i>Emayella augustorita</i>, New Member of Pasteurellaceae, Isolated from Blood Cultures of Septic Patient Open
We report discovery of a new bacterial genus and species of the family Pasteurellaceae by using phylogenetic and metabolic analysis. The bacterium, Emayella augustorita, was isolated from blood cultures of a patient in France diagnosed wit…
View article: Phagosomal granulocytic ROS in septic patients induce the bacterial SOS response
Phagosomal granulocytic ROS in septic patients induce the bacterial SOS response Open
Septic patients with worst clinical prognosis have increased circulating immature granulocytes (IG), displaying limited phagocytosis and reactive oxygen species (ROS) production. Here, we developed an ex vivo model of incubation of …
View article: Modeling the impact of urban and hospital eco-exposomes on antibiotic-resistance dynamics in wastewaters
Modeling the impact of urban and hospital eco-exposomes on antibiotic-resistance dynamics in wastewaters Open
The emergence and selection of antibiotic resistance is a major public health problem worldwide. The presence of antibiotic-resistant bacteria (ARBs) in natural and anthropogenic environments threatens the sustainability of efforts to redu…
View article: Characterization of <i>Pseudomonas aeruginosa</i> resistance to ceftolozane-tazobactam due to <i>ampC</i> and/or <i>ampD</i> mutations observed during treatment using semi-mechanistic PKPD modeling
Characterization of <i>Pseudomonas aeruginosa</i> resistance to ceftolozane-tazobactam due to <i>ampC</i> and/or <i>ampD</i> mutations observed during treatment using semi-mechanistic PKPD modeling Open
A double ampC (AmpC G183D ) and ampD (AmpD H157Y ) genes mutations have been identified by whole genome sequencing in a Pseudomonas aeruginosa (PaS) that became resistant (PaR) in a patient treated by ceftolozane/tazobactam (C/T). To preci…
View article: Tracking des transferts des bactéries porteuses de résistances entre animal, homme et environnement
Tracking des transferts des bactéries porteuses de résistances entre animal, homme et environnement Open
La lutte contre la résistance aux antibiotiques doit intégrer le concept « Une seule santé » pour être efficace. Ceci consiste à avoir une approche holistique embrassant les différents écosystèmes, homme, animal et environnement. Des trans…
View article: Hospital and urban wastewaters shape the matrix and active resistome of environmental biofilms
Hospital and urban wastewaters shape the matrix and active resistome of environmental biofilms Open
View article: Towards One Health surveillance of antibiotic resistance: characterisation and mapping of existing programmes in humans, animals, food and the environment in France, 2021
Towards One Health surveillance of antibiotic resistance: characterisation and mapping of existing programmes in humans, animals, food and the environment in France, 2021 Open
Background International organisations are calling for One Health approaches to tackle antimicrobial resistance. In France, getting an overview of the current surveillance system and its level of integration is difficult due to the diversi…
View article: Evaluation du résistome des communautés microbiennes des biofilms et sédiments comme indicateurs de vulnérabilité et/ou de résilience du milieu aux contaminants
Evaluation du résistome des communautés microbiennes des biofilms et sédiments comme indicateurs de vulnérabilité et/ou de résilience du milieu aux contaminants Open
Ces travaux s’inscrivent dans la continuité de la phase VI du programme Piren-Seine (suivis de contamination et d’impacts écotoxicologiques sur l’axe Seine) et s’appuient sur des acquis d’études menées dans la partie aval du bassin de la S…
View article: Dynamics of the digestive acquisition of bacterial carriage and integron presence by French preterm newborns according to maternal colonization: The DAIR3N multicentric study
Dynamics of the digestive acquisition of bacterial carriage and integron presence by French preterm newborns according to maternal colonization: The DAIR3N multicentric study Open
Objectives The study aimed to describe the dynamics and risk factors of Gram-negative bacteria (GNB) acquisition in preterm infants. Methods This prospective multicenter French study included mothers hospitalized for preterm delivery and t…
View article: Hospital and urban wastewaters shape the structure and active resistome of environmental biofilms
Hospital and urban wastewaters shape the structure and active resistome of environmental biofilms Open
Background Demonstration of the transfer, dynamics, and regulation of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in a complex environmental matrix is yet experimentally challenging, with many essential open quest…
View article: Transferable exclusivity voucher: a flawed incentive to stimulate antibiotic innovation
Transferable exclusivity voucher: a flawed incentive to stimulate antibiotic innovation Open
View article: Hospital and urban wastewaters shape the structure and active resistome of environmental biofilms
Hospital and urban wastewaters shape the structure and active resistome of environmental biofilms Open
Background Demonstration of the transfer, dynamics, and regulation of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in a complex environmental matrix is yet experimentally challenging, with many essential open quest…
View article: A qnrD-Plasmid Promotes Biofilm Formation and Class 1 Integron Gene Cassette Rearrangements in Escherichia coli
A qnrD-Plasmid Promotes Biofilm Formation and Class 1 Integron Gene Cassette Rearrangements in Escherichia coli Open
Bacteria within biofilms may be exposed to sub-minimum inhibitory concentrations (sub-MICs) of antibiotics. Cell-to-cell contact within biofilms facilitates horizontal gene transfers and favors induction of the SOS response. Altogether, it…
View article: Activation of class 1 integron integrase is promoted in the intestinal environment
Activation of class 1 integron integrase is promoted in the intestinal environment Open
Class 1 integrons are widespread genetic elements playing a major role in the dissemination of antibiotic resistance. They allow bacteria to capture, express and exchange antibiotic resistance genes embedded within gene cassettes. Acquisit…
View article: Routine use of 16S rRNA PCR and subsequent sequencing from blood samples in septic shock: about two case reports of Capnocytophaga canimorsus infection in immunocompetent patients
Routine use of 16S rRNA PCR and subsequent sequencing from blood samples in septic shock: about two case reports of Capnocytophaga canimorsus infection in immunocompetent patients Open
View article: Resistome Diversity and Dissemination of WHO Priority Antibiotic Resistant Pathogens in Lebanese Estuaries
Resistome Diversity and Dissemination of WHO Priority Antibiotic Resistant Pathogens in Lebanese Estuaries Open
Anthropogenic pressure is known to be a key driver of antimicrobial resistance (AMR) dissemination in the environment. Especially in lower income countries, with poor infrastructure, the level of AMR dissemination is high. Therefore, we as…
View article: Modelling the impact of urban and hospital wastewaters eco-exposomes on the antibiotic-resistance dynamics
Modelling the impact of urban and hospital wastewaters eco-exposomes on the antibiotic-resistance dynamics Open
Antibiotic-resistance emergence and selection have become major public health issues globally. The presence of antibiotic resistant bacteria (ARB) in natural and anthroposophical environments threatens to compromise the sustainability of c…
View article: Seasonal resistome diversity and dissemination of WHO priority antibiotic-resistant pathogens in Lebanese estuaries
Seasonal resistome diversity and dissemination of WHO priority antibiotic-resistant pathogens in Lebanese estuaries Open
Anthropogenic activities are demonstrated to be the key drivers of antimicrobial resistance (AMR) dissemination in the environment. Lebanese rivers that lead to the Mediterranean Sea were sampled at estuaries’ sites, under high anthropogen…
View article: Defining the scope of the European Antimicrobial Resistance Surveillance network in Veterinary medicine (EARS-Vet): a bottom-up and One Health approach
Defining the scope of the European Antimicrobial Resistance Surveillance network in Veterinary medicine (EARS-Vet): a bottom-up and One Health approach Open
Background Building the European Antimicrobial Resistance Surveillance network in Veterinary medicine (EARS-Vet) was proposed to strengthen the European One Health antimicrobial resistance (AMR) surveillance approach. Objectives To define …
View article: Integron detection for prediction of trimethoprim/sulfamethoxazole susceptibility in children with Enterobacterales urinary tract infections
Integron detection for prediction of trimethoprim/sulfamethoxazole susceptibility in children with Enterobacterales urinary tract infections Open
Objectives In some countries, third-generation cephalosporins (3GCs) serve as first-line therapy in children with urinary tract infections (UTIs). However, their use may contribute to the emergence of antibiotic resistance, notably among G…
View article: Microniches in biofilm depth are hot-spots for antibiotic resistance acquisition in response to <i>in situ</i> stress
Microniches in biofilm depth are hot-spots for antibiotic resistance acquisition in response to <i>in situ</i> stress Open
Class 1 integrons play a major role in antibiotic resistance dissemination among Gram-negative bacteria. They are genetic platforms able to capture, exchange and express antibiotic resistance gene cassettes. The integron integrase, whose e…
View article: Author response: A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli
Author response: A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli Open
View article: Integrons, a predictive biomarker for antibiotic resistance in acute sepsis: the IRIS study
Integrons, a predictive biomarker for antibiotic resistance in acute sepsis: the IRIS study Open
Background Considering the increase in MDR Gram-negative bacteria (GNB), the choice of empirical antibiotic therapy is challenging. In parallel, use of broad-spectrum antibiotics should be avoided to decrease antibiotic selection pressure.…