Aaron C. Tan
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View article: Utilization, Reimbursement, and Barriers to Accessing Sequencing Tests for Cancer Care in the Asia-Pacific Region: KSMO Initiatives to Address Cancer Care Inequity
Utilization, Reimbursement, and Barriers to Accessing Sequencing Tests for Cancer Care in the Asia-Pacific Region: KSMO Initiatives to Address Cancer Care Inequity Open
The findings demonstrated a wide disparity in access, funding and reimbursement of sequencing tests across the region. Addressing cost, improving reimbursement mechanisms, and building infrastructure capacity will be critical for the equit…
View article: Combining recombinant human endostatin with third-generation EGFR-TKIs in advanced EGFR-sensitive mutant non-small cell lung cancer
Combining recombinant human endostatin with third-generation EGFR-TKIs in advanced EGFR-sensitive mutant non-small cell lung cancer Open
In this real-world study, the combination of recombinant human endostatin and third-generation EGFR-TKIs significantly improved the ORR, PFS, and OS in previously untreated advanced EGFR-mutant NSCLC patients and thus represents a promisin…
View article: Self‐Enhancing Drug Pair‐Driven Selenium Nanotherapeutics Reverses Microglial Pyroptosis Through NLRP3/Caspase‐1 Pathway and Neuronal Apoptosis for Treatment of Spinal Cord Injury
Self‐Enhancing Drug Pair‐Driven Selenium Nanotherapeutics Reverses Microglial Pyroptosis Through NLRP3/Caspase‐1 Pathway and Neuronal Apoptosis for Treatment of Spinal Cord Injury Open
Spinal cord injury (SCI) constitutes a critical occurrence that results in the disruption of both motor and sensory functions. Oxidative stress‐induced apoptosis and pyroptosis have been identified as critical contributors to neuronal dama…
View article: Supplementary Figure 8 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
Supplementary Figure 8 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Area under the receiver operating curve (AUC) of the cancer-DEG model on 6 test datasets.
View article: FIGURE 6 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
FIGURE 6 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Predictive modeling of response to immune checkpoint inhibition. A, Schematic of data and methods used in model training and testing. B, Top ranked features of ICB response selected by LASSO logistic regression. C, Comparisons of the perfo…
View article: FIGURE 3 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
FIGURE 3 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Validation and characterization of stromal DEGs with scRNA-seq and immune cell deconvolution analysis. A, Dotplot showing the percentage of stromal (nonmalignant) cells expressing each gene for each response category. Color represents the …
View article: Supplementary Figure 7 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
Supplementary Figure 7 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Correlations between the abundance of immune cell subtypes with the gene expression of top stromal biomarkers in individual cohorts.
View article: Supplementary Figure 2 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
Supplementary Figure 2 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Validation of bulk tumor expression deconvolution in ICB-treated cohorts.
View article: FIGURE 6 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
FIGURE 6 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Predictive modeling of response to immune checkpoint inhibition. A, Schematic of data and methods used in model training and testing. B, Top ranked features of ICB response selected by LASSO logistic regression. C, Comparisons of the perfo…
View article: Supplementary Table 3 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
Supplementary Table 3 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Data source of the ICB cohort.
View article: FIGURE 2 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
FIGURE 2 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
DEGs and pathways between responders and nonresponders in the stroma. A, Heat map of genes consistently differentially expressed across discovery cohorts in the stroma. Heat maps are colored by the log2 fold change of gene expression. P-va…
View article: Supplementary Table 3 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
Supplementary Table 3 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Data source of the ICB cohort.
View article: Supplementary Table 2 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
Supplementary Table 2 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Mean correlation coefficients between stroma DES and immune cell subsets across all discovery cohorts.
View article: Supplementary Figure 4 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
Supplementary Figure 4 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Evaluation of cell-type specific expression of top DEGs using single cell RNAseq data.
View article: Supplementary Table 1 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
Supplementary Table 1 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Clinical characteristics of the study cohorts.
View article: Supplementary Figure 9 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
Supplementary Figure 9 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Supplementary Figure 9
View article: Supplementary Figure 7 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
Supplementary Figure 7 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Correlations between the abundance of immune cell subtypes with the gene expression of top stromal biomarkers in individual cohorts.
View article: Supplementary Figure 3 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
Supplementary Figure 3 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Identification of genes that are differentially expressed between responders and non-responders consistently across discovery cohorts.
View article: Supplementary Figure 3 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
Supplementary Figure 3 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Identification of genes that are differentially expressed between responders and non-responders consistently across discovery cohorts.
View article: FIGURE 4 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
FIGURE 4 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
DEGs between responders and nonresponders in the cancer compartment. A, Heat map of genes consistently differentially expressed across discovery cohorts in the cancer cells. Heat maps are colored by the log2 fold change of gene expression.…
View article: FIGURE 1 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
FIGURE 1 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Data summary and schematic of workflow for the analysis of determinants of immunotherapy response.
View article: FIGURE 1 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
FIGURE 1 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Data summary and schematic of workflow for the analysis of determinants of immunotherapy response.
View article: FIGURE 5 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
FIGURE 5 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Analysis of ligand and receptor expression of immune modulators. Inferred ligand and receptor expression in the cancer and stroma compartments for immune checkpoint–related proteins (A) and cytokines (B). Heat maps are colored by the signe…
View article: Supplementary Figure 1 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
Supplementary Figure 1 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Schematic of bulk tumor expression deconvolution and permutation test to identify differentially expressed genes between responders and non-responders in both cancer and stroma compartments.
View article: Supplementary Figure 8 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response
Supplementary Figure 8 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response Open
Area under the receiver operating curve (AUC) of the cancer-DEG model on 6 test datasets.