Marie E. Gaine
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View article: Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group Open
Suicidality phenotypes, consisting of suicidal ideation (SI), suicide attempt (SA), and suicide death (SD), are all heritable but present unique challenges in genome-wide association studies (GWAS) due to their individual complexity, overl…
View article: Complement contributes to hyperactive behavior in the 16p11.2 hemideletion mouse model
Complement contributes to hyperactive behavior in the 16p11.2 hemideletion mouse model Open
The complement system is a major component of the innate immune system and plays an important role in immune surveillance. Recent research has demonstrated that the complement system also plays pivotal roles in brain development, and dysre…
View article: Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group Open
Suicidality phenotypes, consisting of suicidal ideation (SI), suicide attempt (SA), and suicide death (SD), are all heritable but present unique challenges in genome-wide association studies (GWAS) due to their individual complexity, overl…
View article: SNP-Associated Differential Methylation in<i>ARHGEF38:</i>Insights into Genetic-Epigenetic Interactions
SNP-Associated Differential Methylation in<i>ARHGEF38:</i>Insights into Genetic-Epigenetic Interactions Open
Objective Associations have been seen between suicidal behavior and differential DNA methylation of certain genes, with one study showing significant hypomethylation of ARHGEF38 in postmortem brain samples from individuals with bipolar dis…
View article: Patterns of Immune Dysregulation in Bipolar Disorder
Patterns of Immune Dysregulation in Bipolar Disorder Open
Background Bipolar disorder is a debilitating mood disorder associated with a high risk of suicide and characterized by immune dysregulation. In this study, we used a multi-faceted approach to better distinguish the pattern of dysregulatio…
View article: A mutation in the <i>PRKAR1B</i> gene drives pathological mechanisms of neurodegeneration across species
A mutation in the <i>PRKAR1B</i> gene drives pathological mechanisms of neurodegeneration across species Open
Protein kinase A (PKA) neuronal function is controlled by the interaction of a regulatory (R) subunit dimer with two catalytic subunits. Recently, the L50R variant in the gene encoding the RIβ subunit was identified in individuals with a n…
View article: Investigating the relationship between DNA methylation, genetic variation, and suicide attempt in bipolar disorder
Investigating the relationship between DNA methylation, genetic variation, and suicide attempt in bipolar disorder Open
Individuals with bipolar disorder are at increased risk for suicide, and this can be influenced by a range of biological, clinical, and environmental risk factors. Biological components associated with suicide include DNA modifications tha…
View article: Protein Kinase A in neurological disorders
Protein Kinase A in neurological disorders Open
Cyclic adenosine 3’, 5’ monophosphate (cAMP)-dependent Protein Kinase A (PKA) is a multi-functional serine/threonine kinase that regulates a wide variety of physiological processes including gene transcription, metabolism, and synaptic pla…
View article: Organophosphorus pesticide exposure from house dust and parent-reported child behavior in Latino children from an orchard community
Organophosphorus pesticide exposure from house dust and parent-reported child behavior in Latino children from an orchard community Open
View article: Blood epigenome-wide association studies of suicide attempt in adults with bipolar disorder
Blood epigenome-wide association studies of suicide attempt in adults with bipolar disorder Open
Suicide attempt (SA) risk is elevated in individuals with bipolar disorder (BD), and DNA methylation patterns may serve as possible biomarkers of SA. We conducted epigenome-wide association studies (EWAS) of blood DNA methylation associate…
View article: Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders
Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders Open
View article: 16p11.2 Microduplication is Associated with Lobule-Specific Abnormalities in Cerebellar Structure and Function
16p11.2 Microduplication is Associated with Lobule-Specific Abnormalities in Cerebellar Structure and Function Open
The 16p11.2 microduplication (16p11.2 dp/+ ) is associated with several neuropsychiatric disorders including schizophrenia, autism spectrum disorder, bipolar disorder, intellectual disability, and attention deficit/hyperactivity disorder (…
View article: Cerebellar morphological differences and associations with extrinsic factors in bipolar disorder type I
Cerebellar morphological differences and associations with extrinsic factors in bipolar disorder type I Open
View article: Blood epigenome-wide association studies of suicide attempt in adults with bipolar disorder
Blood epigenome-wide association studies of suicide attempt in adults with bipolar disorder Open
Suicide attempt (SA) risk is elevated in individuals with bipolar disorder (BD), and DNA methylation patterns may serve as possible biomarkers of SA. We conducted epigenome-wide association studies (EWAS) of blood DNA methylation associate…
View article: Association between the epigenetic lifespan predictor GrimAge and history of suicide attempt in bipolar disorder
Association between the epigenetic lifespan predictor GrimAge and history of suicide attempt in bipolar disorder Open
View article: Cerebellar Morphological Differences in Bipolar Disorder Type I
Cerebellar Morphological Differences in Bipolar Disorder Type I Open
Background The neural underpinnings of bipolar disorder (BD) remain poorly understood. The cerebellum is ideally positioned to modulate emotional regulation circuitry yet has been understudied in BD. Previous studies have suggested differe…
View article: Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders
Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders Open
Neurodevelopmental disorders (NDDs) are polygenic in nature and copy number variants (CNVs) are ideal candidates to study the nature of this polygenic risk. The disruption of striatal circuits is considered a central mechanism in NDDs. The…
View article: Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders
Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders Open
Neurodevelopmental disorders (NDDs) are polygenic in nature and copy number variants (CNVs) are ideal candidates to study the nature of this polygenic risk. The disruption of striatal circuits is considered a central mechanism in NDDs. The…
View article: Association between the Epigenetic Lifespan Predictor GrimAge and History of Suicide Attempt in Bipolar Disorder
Association between the Epigenetic Lifespan Predictor GrimAge and History of Suicide Attempt in Bipolar Disorder Open
Bipolar disorder (BD) has been previously associated with premature mortality and aging, including acceleration of epigenetic aging. Suicide attempts (SA) are greatly elevated in BD and are associated with decreased lifespan, biological ag…
View article: A Genotype–Phenotype Analysis of Glutathione Peroxidase 4 in Human Atrial Myocardium and Its Association with Postoperative Atrial Fibrillation
A Genotype–Phenotype Analysis of Glutathione Peroxidase 4 in Human Atrial Myocardium and Its Association with Postoperative Atrial Fibrillation Open
Heterogeneity in the incidence of postoperative atrial fibrillation (POAF) following heart surgery implies that underlying genetic and/or physiological factors impart a higher risk of this complication to certain patients. Glutathione pero…
View article: Altered hippocampal transcriptome dynamics following sleep deprivation
Altered hippocampal transcriptome dynamics following sleep deprivation Open
View article: Altered hippocampal transcriptome dynamics following sleep deprivation
Altered hippocampal transcriptome dynamics following sleep deprivation Open
Widespread sleep deprivation is a continuing public health problem in the United States and worldwide affecting adolescents and adults. Acute sleep deprivation results in decrements in spatial memory and cognitive impairments. The hippocam…
View article: Additional file 2 of Altered hippocampal transcriptome dynamics following sleep deprivation
Additional file 2 of Altered hippocampal transcriptome dynamics following sleep deprivation Open
Additional file 2: Table S1. RT-qPCR primers used. Validation of RNA-seq results was performed using RT-qPCR, SYBR technology, and custom designed primers. Table S2. Genes significantly upregulated by sleep deprivation. We compared non-sle…
View article: Translational changes induced by acute sleep deprivation uncovered by TRAP-Seq
Translational changes induced by acute sleep deprivation uncovered by TRAP-Seq Open
View article: The CBP KIX domain regulates long-term memory and circadian activity
The CBP KIX domain regulates long-term memory and circadian activity Open
View article: The CBP KIX domain regulates long-term memory and circadian activity
The CBP KIX domain regulates long-term memory and circadian activity Open
CREB-dependent transcription necessary for long-term memory is driven by interactions with CREB-binding protein (CBP), a multi-domain protein that binds numerous transcription factors. Identifying specific domain functions for multi-action…
View article: Additional file 2 of Translational changes induced by acute sleep deprivation uncovered by TRAP-Seq
Additional file 2 of Translational changes induced by acute sleep deprivation uncovered by TRAP-Seq Open
Additional file 2: Table S1. List of differentially expressed transcripts in the translatome after sleep deprivation. Table S2. List of differentially expressed isoforms in the translatome after sleep deprivation. Table S3. List of genes r…
View article: Additional file 2 of The CBP KIX domain regulates long-term memory and circadian activity
Additional file 2 of The CBP KIX domain regulates long-term memory and circadian activity Open
Additional file 2 : Table S1. List of Genes Differentially Expressed in CBPKIX/KIX mutants compared to wild-type littermates after spatial learning. Table S2. List of the upstream regulators of the DEGs in CBPKIX/KIX mutants. Table S3. Lis…
View article: Targeted sequencing of the <i>LRRTM</i> gene family in suicide attempters with bipolar disorder
Targeted sequencing of the <i>LRRTM</i> gene family in suicide attempters with bipolar disorder Open
Glutamatergic signaling is the primary excitatory neurotransmission pathway in the brain, and its relationship to neuropsychiatric disorders is of considerable interest. Our previous attempted suicide genome‐wide association study, and num…
View article: Male-specific association of the 2p25 region with suicide attempt in bipolar disorder
Male-specific association of the 2p25 region with suicide attempt in bipolar disorder Open