Marie E. Rognes
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View article: Advection versus diffusion in brain ventricular transport
Advection versus diffusion in brain ventricular transport Open
Cerebrospinal fluid (CSF) is integral to brain function. CSF provides mechanical support for the brain and helps distribute nutrients, neurotransmitters and metabolites throughout the central nervous system. CSF flow is driven by several p…
View article: Heterogeneity in human brain clearance adds resilience against tauopathy – a computational model informed by glymphatic MRI
Heterogeneity in human brain clearance adds resilience against tauopathy – a computational model informed by glymphatic MRI Open
Neurotoxic protein fragments such as amyloid-beta and tau accumulate in characteristic staging patterns in Alzheimer’s disease (AD). The brain clears such metabolic substances via multiple different systems, including via the glymphatic (e…
View article: Stretch and flow at the gliovascular interface: high-fidelity modelling of the mechanics of astrocyte endfeet
Stretch and flow at the gliovascular interface: high-fidelity modelling of the mechanics of astrocyte endfeet Open
Astrocyte endfeet form a near-continuous sheath around the brain’s vasculature, defining the perivascular space (PVS) implicated in fluid flow and solute transport. Yet, their precise physiological role remains incompletely understood. Thi…
View article: Advection versus diffusion in brain ventricular transport
Advection versus diffusion in brain ventricular transport Open
Cerebrospinal fluid (CSF) is integral to brain function. CSF provides mechanical support for the brain and helps distribute nutrients, neurotransmitters and metabolites throughout the central nervous system. CSF flow is driven by several p…
View article: In-silico molecular enrichment and clearance of the human intracranial space
In-silico molecular enrichment and clearance of the human intracranial space Open
The mechanisms of intracranial solute transport are fundamental to human brain health, with alterations often linked to disease and functional impairment, and with distinct opportunities for personalized diagnostics and treatment. However,…
View article: The modelling error in multi-dimensional time-dependent solute transport models
The modelling error in multi-dimensional time-dependent solute transport models Open
Starting from full-dimensional models of solute transport, we derive and analyze multi-dimensional models of time-dependent convection, diffusion, and exchange in and around pulsating vascular and perivascular networks. These models are wi…
View article: Spatial modeling algorithms for reactions and transport (SMART) in biological cells
Spatial modeling algorithms for reactions and transport (SMART) in biological cells Open
Biological cells rely on precise spatiotemporal coordination of biochemical reactions to control their many functions. Such cell signaling networks have been a common focus for mathematical models, but they remain challenging to simulate, …
View article: Spatial modeling algorithms for reactions and transport (SMART) in biological cells
Spatial modeling algorithms for reactions and transport (SMART) in biological cells Open
Biological cells rely on precise spatiotemporal coordination of biochemical reactions to control their many functions. Such cell signaling networks have been a common focus for mathematical models, but they remain challenging to simulate, …
View article: Modeling CSF circulation and the glymphatic system during infusion using subject specific intracranial pressures and brain geometries
Modeling CSF circulation and the glymphatic system during infusion using subject specific intracranial pressures and brain geometries Open
Background: Infusion testing is an established method for assessing CSF resistance in patients with idiopathic normal pressure hydrocephalus (iNPH). To what extent the increased resistance is related to the glymphatic system is an open que…
View article: Modeling CSF circulation and the glymphatic system during infusion using subject specific intracranial pressures and brain geometries
Modeling CSF circulation and the glymphatic system during infusion using subject specific intracranial pressures and brain geometries Open
Background Infusion testing is an established method for assessing CSF resistance in patients with idiopathic normal pressure hydrocephalus (iNPH). To what extent the increased resistance is related to the glymphatic system is an open ques…
View article: Scalable approximation and solvers for ionic electrodiffusion in cellular geometries
Scalable approximation and solvers for ionic electrodiffusion in cellular geometries Open
The activity and dynamics of excitable cells are fundamentally regulated and moderated by extracellular and intracellular ion concentrations and their electric potentials. The increasing availability of dense reconstructions of excitable t…
View article: Directional flow in perivascular networks: Mixed finite elements for reduced-dimensional models on graphs
Directional flow in perivascular networks: Mixed finite elements for reduced-dimensional models on graphs Open
The flow of cerebrospinal fluid through the perivascular spaces of the brain is believed to play a crucial role in eliminating toxic waste proteins. While the driving forces of this flow have been enigmatic, experiments have shown that art…
View article: Supplementary Material. DOLFINx: The next generation FEniCS problem solving environment.
Supplementary Material. DOLFINx: The next generation FEniCS problem solving environment. Open
Supplementary material for the paper "DOLFINx: The next generation FEniCS problem solving environment". The snippets from the paper are licensed under the MIT License. The FEniCSx component source code is licensed according to the licenses…
View article: Supplementary Material. DOLFINx: The next generation FEniCS problem solving environment.
Supplementary Material. DOLFINx: The next generation FEniCS problem solving environment. Open
Supplementary material for the paper "DOLFINx: The next generation FEniCS problem solving environment". The snippets from the paper are licensed under the MIT License. The FEniCSx component source code is licensed according to the licenses…
View article: Are brain displacements and pressures within the parenchyma induced by surface pressure differences? A computational modelling study
Are brain displacements and pressures within the parenchyma induced by surface pressure differences? A computational modelling study Open
The intracranial pressure is implicated in many homeostatic processes in the brain and is a fundamental parameter in several diseases such as e.g. idiopathic normal pressure hydrocephalus. The presence of a small but persistent pulsatile i…
View article: The directional flow generated by peristalsis in perivascular networks—Theoretical and numerical reduced-order descriptions
The directional flow generated by peristalsis in perivascular networks—Theoretical and numerical reduced-order descriptions Open
Directional fluid flow in perivascular spaces surrounding cerebral arteries is hypothesized to play a key role in brain solute transport and clearance. While various drivers for a pulsatile flow, such as cardiac or respiratory pulsations, …
View article: SMART: Spatial Modeling Algorithms for Reactions andTransport
SMART: Spatial Modeling Algorithms for Reactions andTransport Open
Recent advances in microscopy and 3D reconstruction methods have allowed for characterization of cellular morphology in unprecedented detail, including the irregular geometries of intracellular subcompartments such as membrane-bound organe…
View article: The directional flow generated by peristalsis in perivascular networks -- theoretical and numerical reduced-order descriptions
The directional flow generated by peristalsis in perivascular networks -- theoretical and numerical reduced-order descriptions Open
Directional fluid flow in perivascular spaces surrounding cerebral arteries is hypothesized to play a key role in brain solute transport and clearance. While various drivers for pulsatile flow, such as cardiac or respiratory pulsations, ar…
View article: Modeling excitable cells with the EMI equations: spectral analysis and iterative solution strategy
Modeling excitable cells with the EMI equations: spectral analysis and iterative solution strategy Open
In this work, we are interested in solving large linear systems stemming from the Extra-Membrane-Intra (EMI) model, which is employed for simulating excitable tissues at a cellular scale. After setting the related systems of partial differ…
View article: Neural activity induces strongly coupled electro-chemo-mechanical interactions and fluid flow in astrocyte networks and extracellular space—A computational study
Neural activity induces strongly coupled electro-chemo-mechanical interactions and fluid flow in astrocyte networks and extracellular space—A computational study Open
The complex interplay between chemical, electrical, and mechanical factors is fundamental to the function and homeostasis of the brain, but the effect of electrochemical gradients on brain interstitial fluid flow, solute transport, and cle…