Marie E. Wang
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View article: Incidence and Management of Urinary Tract Infection in a National Medicaid Population, 2009-2019
Incidence and Management of Urinary Tract Infection in a National Medicaid Population, 2009-2019 Open
BACKGROUND AND OBJECTIVE Recent investigations and the most recent American Academy of Pediatrics guidelines have advocated for stricter criteria for urinary tract infection (UTI) diagnosis and a more selective approach to voiding cystoure…
View article: Intravenous Dexamethasone Use and Outcomes in Children Hospitalized With Septic Arthritis
Intravenous Dexamethasone Use and Outcomes in Children Hospitalized With Septic Arthritis Open
BACKGROUND Septic arthritis is routinely treated with joint drainage and antibiotics; however, adjunctive systemic corticosteroids may improve outcomes. OBJECTIVES To (1) describe variation in intravenous dexamethasone use and (2) evaluate…
View article: Prioritization of Randomized Clinical Trial Questions for Children Hospitalized With Common Conditions
Prioritization of Randomized Clinical Trial Questions for Children Hospitalized With Common Conditions Open
Importance There is a lack of randomized clinical trial (RCT) data to guide many routine decisions in the care of children hospitalized for common conditions. A first step in addressing the shortage of RCTs for this population is to identi…
View article: Incidence of Pediatric Urinary Tract Infections Before and During the COVID-19 Pandemic
Incidence of Pediatric Urinary Tract Infections Before and During the COVID-19 Pandemic Open
IMPORTANCE Urinary tract infection (UTI) is common in children, but the population incidence is largely unknown. Controversy surrounds the optimal diagnostic criteria and how to balance the risks of undertreatment and overtreatment. Change…
View article: 1304. Early Surgical Procedures and Clinical Outcomes Among Children Hospitalized with Acute Hematogenous Osteomyelitis
1304. Early Surgical Procedures and Clinical Outcomes Among Children Hospitalized with Acute Hematogenous Osteomyelitis Open
Background Surgical biopsy and drainage may have diagnostic and therapeutic benefits for children with acute hematogenous osteomyelitis (AHO). However, it remains unknown whether routinely expediting surgical procedures improves clinical o…
View article: Prevalence of Urinary Tract Infection, Bacteremia, and Meningitis Among Febrile Infants Aged 8 to 60 Days With SARS-CoV-2
Prevalence of Urinary Tract Infection, Bacteremia, and Meningitis Among Febrile Infants Aged 8 to 60 Days With SARS-CoV-2 Open
Importance The prevalence of urinary tract infection (UTI), bacteremia, and bacterial meningitis in febrile infants with SARS-CoV-2 is largely unknown. Knowledge of the prevalence of these bacterial infections among febrile infants with SA…
View article: Healthcare utilization in children across the care continuum during the COVID-19 pandemic
Healthcare utilization in children across the care continuum during the COVID-19 pandemic Open
Objectives Healthcare utilization decreased during the COVID-19 pandemic, likely due to reduced transmission of infections and healthcare avoidance. Though various investigations have described these changing patterns in children, most hav…
View article: Frequency and Consequences of Routine Temperature Measurement at Well-Child Visits
Frequency and Consequences of Routine Temperature Measurement at Well-Child Visits Open
OBJECTIVES To determine the (1) frequency and visit characteristics of routine temperature measurement and (2) rates of interventions by temperature measurement practice and the probability of incidental fever detection. METHODS In this re…
View article: 1148. Duration of Antibiotic Therapy in the Treatment of Bacterial Meningitis in Young Infants: A Systematic Review and Narrative Synthesis
1148. Duration of Antibiotic Therapy in the Treatment of Bacterial Meningitis in Young Infants: A Systematic Review and Narrative Synthesis Open
Background IDSA recommendations of 14-21 days of parenteral therapy for bacterial meningitis are based predominantly on expert consensus. Parenteral durations consistent with these recommendations are sometimes provided even when meningiti…
View article: Management and Outcomes in Children with Third-Generation Cephalosporin-Resistant Urinary Tract Infections
Management and Outcomes in Children with Third-Generation Cephalosporin-Resistant Urinary Tract Infections Open
Background Third-generation cephalosporin-resistant urinary tract infections (UTIs) often have limited oral antibiotic options with some children receiving prolonged parenteral courses. Our objectives were to determine predictors of long p…
View article: Characteristics of Afebrile Infants ≤60 Days of Age With Invasive Bacterial Infections
Characteristics of Afebrile Infants ≤60 Days of Age With Invasive Bacterial Infections Open
OBJECTIVES: To describe the characteristics and outcomes of afebrile infants ≤60 days old with invasive bacterial infection (IBI). METHODS: We conducted a secondary analysis of a cross-sectional study of infants ≤60 days old with IBI prese…
View article: Febrile Infants ≤60 Days Old With Positive Urinalysis Results and Invasive Bacterial Infections
Febrile Infants ≤60 Days Old With Positive Urinalysis Results and Invasive Bacterial Infections Open
OBJECTIVES: We aimed to describe the clinical and laboratory characteristics of febrile infants ≤60 days old with positive urinalysis results and invasive bacterial infections (IBI). METHODS: We performed a planned secondary analysis of a …
View article: Height of fever and invasive bacterial infection
Height of fever and invasive bacterial infection Open
Objective We aimed to evaluate the association of height of fever with invasive bacterial infection (IBI) among febrile infants <=60 days of age. Methods In a secondary analysis of a multicentre case–control study of non-ill-appearing febr…
View article: Cerebrospinal Fluid Profiles of Infants ≤60 Days of Age With Bacterial Meningitis
Cerebrospinal Fluid Profiles of Infants ≤60 Days of Age With Bacterial Meningitis Open
OBJECTIVES: We aimed to describe the cerebrospinal fluid (CSF) profiles of infants ≤60 days old with bacterial meningitis and the characteristics of infants with bacterial meningitis who did not have CSF abnormalities. METHODS: We included…
View article: Parenteral Antibiotic Therapy Duration in Young Infants With Bacteremic Urinary Tract Infections
Parenteral Antibiotic Therapy Duration in Young Infants With Bacteremic Urinary Tract Infections Open
OBJECTIVES: To determine the association between parenteral antibiotic duration and outcomes in infants ≤60 days old with bacteremic urinary tract infection (UTI). METHODS: This multicenter retrospective cohort study included infants ≤60 d…
View article: Testing for Meningitis in Febrile Well-Appearing Young Infants With a Positive Urinalysis
Testing for Meningitis in Febrile Well-Appearing Young Infants With a Positive Urinalysis Open
BACKGROUND AND OBJECTIVES: To determine factors associated with cerebrospinal fluid (CSF) testing in febrile young infants with a positive urinalysis and assess the probability of delayed diagnosis of bacterial meningitis in infants treate…
View article: A Prediction Model to Identify Febrile Infants ≤60 Days at Low Risk of Invasive Bacterial Infection
A Prediction Model to Identify Febrile Infants ≤60 Days at Low Risk of Invasive Bacterial Infection Open
OBJECTIVES: To derive and internally validate a prediction model for the identification of febrile infants ≤60 days old at low probability of invasive bacterial infection (IBI). METHODS: We conducted a case-control study of febrile infants…
View article: Risk Stratification of Febrile Infants ≤60 Days Old Without Routine Lumbar Puncture
Risk Stratification of Febrile Infants ≤60 Days Old Without Routine Lumbar Puncture Open
OBJECTIVES: To evaluate the Rochester and modified Philadelphia criteria for the risk stratification of febrile infants with invasive bacterial infection (IBI) who do not appear ill without routine cerebrospinal fluid (CSF) testing. METHOD…
View article: Risk factors for possible serious bacterial infection in a rural cohort of young infants in central India
Risk factors for possible serious bacterial infection in a rural cohort of young infants in central India Open
This trial is registered at ClinicalTrials.gov ( NCT01073475 ).
View article: Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multicenter prospective cohort study
Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multicenter prospective cohort study Open
BACKGROUND: Possible severe bacterial infections (pSBI) continue to be a leading cause of global neonatal mortality annually. With the recent publications of simplified antibiotic regimens for treatment of pSBI where referral is not possib…