Marie‐Elise Truchetet
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View article: Deep hierarchical subtyping of multi-organ systemic sclerosis trajectories - a EUSTAR study
Deep hierarchical subtyping of multi-organ systemic sclerosis trajectories - a EUSTAR study Open
Systemic sclerosis (SSc) is a chronic autoimmune disease with multi-organ involvement. Historically, SSc classification has focused on the type of skin involvement (limited versus diffuse); however, a growing evidence of organ-specific var…
View article: Definition of relapse criteria in patients with rapidly progressive systemic sclerosis treated with autologous haemopoietic stem cell transplantation
Definition of relapse criteria in patients with rapidly progressive systemic sclerosis treated with autologous haemopoietic stem cell transplantation Open
View article: French recommendations for assessing and managing the risk of cancer before the initiation of targeted therapies for chronic rheumatic inflammatory diseases
French recommendations for assessing and managing the risk of cancer before the initiation of targeted therapies for chronic rheumatic inflammatory diseases Open
View article: OP0085 Outcomes of upfront combination vs monotherapy with rituximab or mycophenolate mofetil for systemic sclerosis interstitial lung disease (SSc-ILD): results from an EUSTAR cohort study
OP0085 Outcomes of upfront combination vs monotherapy with rituximab or mycophenolate mofetil for systemic sclerosis interstitial lung disease (SSc-ILD): results from an EUSTAR cohort study Open
View article: OP0331 ASSOCIATION BETWEEN VASOACTIVE-VASODILATING THERAPY AND REDUCED DETECTION OF PRE-CAPILLARY PULMONARY HYPERTENSION IN SYSTEMIC SCLEROSIS: EVIDENCE FROM A EUSTAR STUDY
OP0331 ASSOCIATION BETWEEN VASOACTIVE-VASODILATING THERAPY AND REDUCED DETECTION OF PRE-CAPILLARY PULMONARY HYPERTENSION IN SYSTEMIC SCLEROSIS: EVIDENCE FROM A EUSTAR STUDY Open
View article: OP0217 THE CLINICAL PHENOTYPE OF ANTI-Th/To+ PATIENTS IN SYSTEMIC SCLEROSIS: A CASE-CONTROL STUDY WITHIN THE EUROPEAN SCLERODERMA TRIALS AND RESEARCH (EUSTAR) COHORT
OP0217 THE CLINICAL PHENOTYPE OF ANTI-Th/To+ PATIENTS IN SYSTEMIC SCLEROSIS: A CASE-CONTROL STUDY WITHIN THE EUROPEAN SCLERODERMA TRIALS AND RESEARCH (EUSTAR) COHORT Open
View article: OP0216 DISEASE CHARACTERISTICS OF ANTI-CENTROMERE POSITIVE SYSTEMIC SCLEROSIS PATIENTS AND RISK FACTORS FOR ORGAN INVOLVEMENT: DATA FROM THE EUSTAR COHORT
OP0216 DISEASE CHARACTERISTICS OF ANTI-CENTROMERE POSITIVE SYSTEMIC SCLEROSIS PATIENTS AND RISK FACTORS FOR ORGAN INVOLVEMENT: DATA FROM THE EUSTAR COHORT Open
View article: OP0081 Anti-Ro/SSA+/RF+ double seropositivity in systemic sclerosis is associated with more severe interstitial lung disease: A study from the EUSTAR database
OP0081 Anti-Ro/SSA+/RF+ double seropositivity in systemic sclerosis is associated with more severe interstitial lung disease: A study from the EUSTAR database Open
View article: Abatacept versus tocilizumab for the treatment of rheumatoid arthritis in TNF inhibitor inadequate responders: study protocol of the SUNSTAR randomised controlled open-label superiority trial
Abatacept versus tocilizumab for the treatment of rheumatoid arthritis in TNF inhibitor inadequate responders: study protocol of the SUNSTAR randomised controlled open-label superiority trial Open
Introduction Biological disease modifying antirheumatic drugs (bDMARDs) have a central role in the treatment of rheumatoid arthritis (RA). Tumour necrosis factor inhibitors (TNFis) are commonly used as first-line agents, while non-TNFis (t…
View article: ABS0310 IMPACT OF ANTI-CITRULLINATED PROTEIN ANTIBODIES ON TNF INHIBITOR AND JAK INHIBITOR PRESCRIPTIONS IN RHEUMATOID ARTHRITIS: CROSS-SECTIONAL STUDIES FROM THE ART AND MAJIK REGISTRIES
ABS0310 IMPACT OF ANTI-CITRULLINATED PROTEIN ANTIBODIES ON TNF INHIBITOR AND JAK INHIBITOR PRESCRIPTIONS IN RHEUMATOID ARTHRITIS: CROSS-SECTIONAL STUDIES FROM THE ART AND MAJIK REGISTRIES Open
View article: Maintenance of remission after tocilizumab withdrawal in patients with glucocorticoid‐dependent polymyalgia rheumatica
Maintenance of remission after tocilizumab withdrawal in patients with glucocorticoid‐dependent polymyalgia rheumatica Open
Objective The SEMAPHORE trial evaluated the efficacy and safety of tocilizumab (TCZ) in glucocorticoid (GC)‐dependent polymyalgia rheumatica (PMR). TCZ reduced GC use and disease activity at 24 weeks. This study aimed to assess relapse rat…
View article: The effect of hydroxychloroquine on activities of daily living and hand function in systemic sclerosis: results from an analysis of the EUSTAR cohort
The effect of hydroxychloroquine on activities of daily living and hand function in systemic sclerosis: results from an analysis of the EUSTAR cohort Open
View article: Total lung capacity is predictive of disease severity and survival in systemic sclerosis: A longitudinal analysis in 2347 patients from the French National Cohort Study
Total lung capacity is predictive of disease severity and survival in systemic sclerosis: A longitudinal analysis in 2347 patients from the French National Cohort Study Open
View article: Evaluation of Systemic Sclerosis Primary Heart Involvement and Chronic Heart Failure in the European Scleroderma Trials and Research Cohort
Evaluation of Systemic Sclerosis Primary Heart Involvement and Chronic Heart Failure in the European Scleroderma Trials and Research Cohort Open
Background Systemic sclerosis (SSc) primary heart involvement (SSc‐pHI) is one of the leading causes of mortality in SSc. We aimed to evaluate risk factors for SSc‐pHI and its progression and the outcomes in the EUSTAR (European Scleroderm…
View article: A comparative analysis of risk stratification tools in SSc-associated pulmonary arterial hypertension: a EUSTAR analysis
A comparative analysis of risk stratification tools in SSc-associated pulmonary arterial hypertension: a EUSTAR analysis Open
Objectives The 2022 European Society of Cardiology and European Respiratory Society (ESC/ERS) guidelines for pulmonary arterial hypertension (PAH) recommend risk stratification to optimize management. However, the performance of generic PA…
View article: Gastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort
Gastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort Open
Objectives Gastroesophageal reflux disease (GERD) is frequent in systemic sclerosis (SSc) and could predict progression of interstitial lung disease (ILD). We aimed to analyse (1) the prevalence of GERD among SSc-ILD patients, (2) its asso…
View article: Longitudinal association between nailfold capillaroscopy and incident interstitial lung disease: A EUSTAR database analysis
Longitudinal association between nailfold capillaroscopy and incident interstitial lung disease: A EUSTAR database analysis Open
Objectives: To evaluate (1) the association between nailfold capillaroscopy pattern and 5-year risk for incident interstitial lung disease and (2) the association between transition in nailfold capillaroscopy pattern and risk of incident i…
View article: Evaluation of rheumatoid arthritis-associated interstitial lung disease in patients treated with JAK inhibitors: a MAJIK-SFR cohort study
Evaluation of rheumatoid arthritis-associated interstitial lung disease in patients treated with JAK inhibitors: a MAJIK-SFR cohort study Open
Objective To examine the course of interstitial lung disease associated with rheumatoid arthritis (RA-ILD) in France on treatment with Janus kinase inhibitors (JAKis) using the MAJIK-SFR registry. Methods Prospective national multicentre o…
View article: Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis
Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis Open
Systemic sclerosis (SSc) is an autoimmune disease that has a strong female predominance. Both the X-linked TLR7 and TLR8 can induce type I IFN (IFN-I) by plasmacytoid DCs (pDCs), which can promote fibrosis. We identified five subclusters o…
View article: Entre le normal et le pathologique : le concept de pré-maladie appliqué aux pathologies auto-immunes systémiques
Entre le normal et le pathologique : le concept de pré-maladie appliqué aux pathologies auto-immunes systémiques Open
View article: Oral Glucocorticoids for Skin Fibrosis in Early Diffuse Systemic Sclerosis: A Target Trial Emulation Study From the European Scleroderma Trials and Research Group Database
Oral Glucocorticoids for Skin Fibrosis in Early Diffuse Systemic Sclerosis: A Target Trial Emulation Study From the European Scleroderma Trials and Research Group Database Open
Objective The objective of this study is to evaluate whether adding oral glucocorticoids to immunosuppressive therapy improves skin scores and ensures safety in patients with early diffuse cutaneous systemic sclerosis (dcSSc). Methods We p…
View article: Impact of autoantibody status on stratifying the risk of organ involvement and mortality in SSc: experience from a multicentre French cohort of 1605 patients
Impact of autoantibody status on stratifying the risk of organ involvement and mortality in SSc: experience from a multicentre French cohort of 1605 patients Open
Introduction Systemic sclerosis (SSc) is a rare autoimmune disease currently classified into two subgroups based on skin extension. The aim of this study was to determine in a large cohort whether the determination of autoantibody (AAb) pr…
View article: Does regression of skin thickening predict improvement of internal organ involvement and survival in patients with diffuse cutaneous systemic sclerosis? A EUSTAR analysis
Does regression of skin thickening predict improvement of internal organ involvement and survival in patients with diffuse cutaneous systemic sclerosis? A EUSTAR analysis Open
We found that regression of skin fibrosis is associated with a lower probability of lung progression and better survival at follow up. The link between the disease course of skin and lung fibrosis in SSc can help to better stratify patient…
View article: Inflammasome-targeted therapy might prevent adverse perinatal outcomes of recurrent chronic intervillositis of unknown etiology
Inflammasome-targeted therapy might prevent adverse perinatal outcomes of recurrent chronic intervillositis of unknown etiology Open
View article: Comorbidity burden on mortality in patients with systemic sclerosis
Comorbidity burden on mortality in patients with systemic sclerosis Open
Introduction Systemic sclerosis (SSc) is a serious life-threatening tissue disease. A significant aspect of its mortality arises from comorbid conditions. Our study aimed at mapping out the prevalence of these comorbidities and their relat…
View article: EULAR/PReS recommendations for the diagnosis and management of Still's disease, comprising systemic juvenile idiopathic arthritis and adult-onset Still's disease
EULAR/PReS recommendations for the diagnosis and management of Still's disease, comprising systemic juvenile idiopathic arthritis and adult-onset Still's disease Open
View article: Prevalence estimation of a rare disease with the French National Rare Disease Registry: example of TNF receptor associated periodic syndrome (TRAPS)
Prevalence estimation of a rare disease with the French National Rare Disease Registry: example of TNF receptor associated periodic syndrome (TRAPS) Open
Background rare diseases (RD) have progressively emerged as public health priority in many countries. Epidemiology still presents obstacles and extracting data from public health system remains insufficient. In France, RD database set up i…
View article: Preventive effects of early immunosuppressive treatment on the development of interstitial lung disease in systemic sclerosis
Preventive effects of early immunosuppressive treatment on the development of interstitial lung disease in systemic sclerosis Open
Background Hypothesizing that early treatment yields improved prognosis, we aimed to investigate how the timing of immunosuppressive treatment relates to interstitial lung disease (ILD) development and the course of pulmonary function in s…
View article: Diffusing Capacity of the Lungs for Carbon Monoxide and Echocardiographic Parameters in Identifying Mild Pulmonary Hypertension in the EUSTAR Cohort of Patients With Systemic Sclerosis
Diffusing Capacity of the Lungs for Carbon Monoxide and Echocardiographic Parameters in Identifying Mild Pulmonary Hypertension in the EUSTAR Cohort of Patients With Systemic Sclerosis Open
In this study, diffusing capacity of the lungs for carbon monoxide < 80% of the predicted value was the parameter with the highest sensitivity and NPV in detecting patients with SSc with mPAP 21 to 24 mm Hg. TAPSE/sPAP < 0.55 mm/mm Hg had …
View article: Standardized reporting for systematic global evaluation of axial spondyloarthritis: An evidence-based and consensus-driven initiative
Standardized reporting for systematic global evaluation of axial spondyloarthritis: An evidence-based and consensus-driven initiative Open