Marie-Élodie Spaety
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View article: The unfolded protein response-glutathione metabolism axis: A novel target of a cycloruthenated complexes bypassing tumor resistance mechanisms
The unfolded protein response-glutathione metabolism axis: A novel target of a cycloruthenated complexes bypassing tumor resistance mechanisms Open
View article: HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway
HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway Open
Gastric cancer (GC) remains a health issue due to the low efficiency of therapies, such as cisplatin. This unsatisfactory situation highlights the necessity of finding factors impacting GC sensibility to therapies. We analyzed the cisplati…
View article: A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin
A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin Open
Ruthenium complexes are considered as potential replacements for platinum compounds in oncotherapy. Their clinical development is handicapped by a lack of consensus on their mode of action. In this study, we identify three histones (H3.1, …
View article: Implication of epigenetic modifications in response to chemotherapies in gastric cancer : therapeutic perspectives
Implication of epigenetic modifications in response to chemotherapies in gastric cancer : therapeutic perspectives Open
Gastric cancer (GC) is treated by surgical resection combined with chemotherapy based on platinum compounds. The increase in chemotherapy resistance reinforces the need to identify robust molecular markers to tailor treatment and develop t…
View article: Implication des régulations épigénétiques dans la réponse aux chimiothérapies dans les cancers gastriques : perspectives thérapeutiques
Implication des régulations épigénétiques dans la réponse aux chimiothérapies dans les cancers gastriques : perspectives thérapeutiques Open
Gastric cancer (GC) is treated by surgical resection combined with chemotherapy based on platinum compounds. The increase in chemotherapy resistance reinforces the need to identify robust molecular markers to tailor treatment and develop t…