Marie Kleingarn
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View article: Dysregulated complement activation during acute myocardial infarction leads to endothelial glycocalyx degradation and endothelial dysfunction via the C5a:C5a-Receptor1 axis
Dysregulated complement activation during acute myocardial infarction leads to endothelial glycocalyx degradation and endothelial dysfunction via the C5a:C5a-Receptor1 axis Open
Introduction Complement-mediated damage to the myocardium during acute myocardial infarction (AMI), particularly the late components of the terminal pathway (C5-convertase and C5b-9), have previously been characterized. Unfortunately, only…
View article: The complement receptor C5aR2 regulates neutrophil activation and function contributing to neutrophil-driven epidermolysis bullosa acquisita
The complement receptor C5aR2 regulates neutrophil activation and function contributing to neutrophil-driven epidermolysis bullosa acquisita Open
Introduction The function of the second receptor for the complement cleavage product C5a, C5aR2, is poorly understood and often neglected in the immunological context. Using mice with a global deficiency of C5aR2 , we have previously repor…
View article: The Importance of C5aR2 in Neutrophil Function and Its Impact on Neutrophil-mediated Diseases
The Importance of C5aR2 in Neutrophil Function and Its Impact on Neutrophil-mediated Diseases Open
The two receptors for the anaphylatoxin C5a are critically involved in the recruitment of immune cells and activate these cells at sites of inflammation.The pro-inflammatory function of C5aR1 in these processes is well established, whereas…
View article: C5aR1 Activation Drives Early IFN-γ Production to Control Experimental Toxoplasma gondii Infection
C5aR1 Activation Drives Early IFN-γ Production to Control Experimental Toxoplasma gondii Infection Open
Toxoplasma gondii (T. gondii) is a parasite infecting animals and humans. In intermediate hosts, such as humans or rodents, rapidly replicating tachyzoites drive vigorous innate and adaptive immune responses resulting in bradyzoites that s…