Marie‐Christine Morel‐Kopp
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View article: Association of Global Coagulation Profiles With Cardiovascular Risk Factors and Atherosclerosis: A Sex Disaggregated Analysis From the BioHEART‐CT Study
Association of Global Coagulation Profiles With Cardiovascular Risk Factors and Atherosclerosis: A Sex Disaggregated Analysis From the BioHEART‐CT Study Open
Background Although the association between dysregulated coagulation and atherosclerosis is well recognized, individual assays have been of minimal value in understanding disease susceptibility. Here we investigated the association of glob…
View article: Dysregulation of oncogenic factors by GFI1B p32: investigation of a novel <I>GFI1B</I> germline mutation
Dysregulation of oncogenic factors by GFI1B p32: investigation of a novel <i>GFI1B</i> germline mutation Open
GFI1B is a transcription factor essential for the regulation of erythropoiesis and megakaryopoiesis, and pathogenic variants have been associated with thrombocytopenia and bleeding. Analysing thrombocytopenic families by whole exome sequen…
View article: Platelet-Reactive Antibodies in Patients after Ischaemic Stroke—An Epiphenomenon or a Natural Protective Mechanism
Platelet-Reactive Antibodies in Patients after Ischaemic Stroke—An Epiphenomenon or a Natural Protective Mechanism Open
Ischaemic brain damage induces autoimmune responses, including the production of autoantibodies with potential neuroprotective effects. Platelets share unexplained similarities with neurons, and the formation of anti-platelet antibodies ha…
View article: The HEV Ventilator
The HEV Ventilator Open
HEV is a low-cost, versatile, high-quality ventilator, which has been designed in response to the COVID-19 pandemic. The ventilator is intended to be used both in and out of hospital intensive care units, and for both invasive and non-inva…
View article: The clinical heterogeneity of RUNX1 associated familial platelet disorder with predisposition to myeloid malignancy – A case series and review of the literature
The clinical heterogeneity of RUNX1 associated familial platelet disorder with predisposition to myeloid malignancy – A case series and review of the literature Open
Germline mutations of runt-related transcription factor-1 (RUNX1) cause familial platelet disorder with predisposition to myeloid malignancy (FPDMM), most commonly associated with thrombocytopenia and propensity to develop myeloid neoplasm…
View article: <i>GFI1B</i>variants associated with thrombocytopenia
<i>GFI1B</i>variants associated with thrombocytopenia Open
Growth factor-independent 1B (GFI1B) on the long arm of chromosome 9 encodes the GFI1B transcription factor, a member of the GFI zinc (Zn)-finger transcriptional repressor family which plays a pivo...
View article: Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis
Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis Open
GluN1 is a mandatory component of N-methyl-D-aspartate receptors (NMDARs) best known for their roles in the brain, but with increasing evidence for relevance in peripheral tissues, including platelets. Certain anti-GluN1 antibodies reduce …
View article: Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis
Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis Open
GluN1 is a mandatory component of N-methyl-D-aspartate receptors (NMDARs) best known for their roles in the brain, but with increasing evidence for relevance in peripheral tissues, including platelets. Certain anti-GluN1 antibodies reduce …
View article: Role of Nongenomic Signaling Pathways Activated by Aldosterone During Cardiac Reperfusion Injury
Role of Nongenomic Signaling Pathways Activated by Aldosterone During Cardiac Reperfusion Injury Open
Aldosterone (Aldo) activates both genomic and nongenomic signaling pathways in the cardiovascular system. Activation of genomic signaling pathways contributes to the adverse cardiac actions of Aldo during reperfusion injury; however, the e…