Jochen Lang
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View article: Research on topology optimization algorithm in additive manufacturing of continuous fiber reinforced composites based on deep learning
Research on topology optimization algorithm in additive manufacturing of continuous fiber reinforced composites based on deep learning Open
With the rapid development of additive manufacturing technology, continuous fiber reinforced composites (CFRCs) have gradually become the preferred material for high-performance structures due to their excellent mechanical properties. Howe…
View article: Motion Decoupled 3D Gaussian Splatting for Dynamic Object Representation
Motion Decoupled 3D Gaussian Splatting for Dynamic Object Representation Open
Dynamic object modeling is a critical challenge in 3D scene reconstruction. Previous methods typically maintain a canonical space to represent the object model, and a deformation field to express the object motion. However, this approach f…
View article: Slow rather than fast calcium events encode physiological inputs and propagate within islets: Lessons from ultrafast imaging on acute pancreatic tissue slices
Slow rather than fast calcium events encode physiological inputs and propagate within islets: Lessons from ultrafast imaging on acute pancreatic tissue slices Open
International audience
View article: Hawthorn leaf and its extract alleviate high-fat diet-induced obesity and modulate gut microbiome in mice
Hawthorn leaf and its extract alleviate high-fat diet-induced obesity and modulate gut microbiome in mice Open
Obesity has emerged as a global health issue with its prevalence continuously increasing and being associated with multiple comorbidities. Although existing medications are effective, they often come with significant side effects, making d…
View article: Advancing Solid-State Batteries with Nanomaterials: Enhancing Safety, Performance, and Energy Efficiency
Advancing Solid-State Batteries with Nanomaterials: Enhancing Safety, Performance, and Energy Efficiency Open
Solid-state batteries (SSBs) are a promising advancement in energy storage technology, offering higher energy density and improved safety compared to traditional lithium-ion batteries. The integration of nanomaterials into SSBs has the pot…
View article: Comparative Study of Data Processing Techniques for Pancreatic Islets in Organ-on-Chip Applications
Comparative Study of Data Processing Techniques for Pancreatic Islets in Organ-on-Chip Applications Open
International audience
View article: Extracellular electrophysiology on clonal human β-cell spheroids
Extracellular electrophysiology on clonal human β-cell spheroids Open
Background Pancreatic islets are important in nutrient homeostasis and improved cellular models of clonal origin may very useful especially in view of relatively scarce primary material. Close 3D contact and coupling between β-cells are a …
View article: Electrophysiological Characterization of Inducible Pluripotent Stem Cell–Derived Human β-Like Cells and an <i>SLC30A8</i> Disease Model
Electrophysiological Characterization of Inducible Pluripotent Stem Cell–Derived Human β-Like Cells and an <i>SLC30A8</i> Disease Model Open
Inducible pluripotent stem cell–derived human β-like cells (BLCs) hold promise for both therapy and disease modeling, but their generation remains challenging and their functional analyses beyond transcriptomic and morphological assessment…
View article: Electrophysiological characterisation of iPSC-derived human β-like cells and an SLC30A8 disease model
Electrophysiological characterisation of iPSC-derived human β-like cells and an SLC30A8 disease model Open
iPSC-derived human β-like cells (BLC) hold promise for both therapy and disease modelling, but their generation remains challenging and their functional analyses beyond transcriptomic and morphological assessments remain limited. Here, we …
View article: Electrophysiological characterisation of iPSC-derived human β-like cells and an SLC30A8 disease model
Electrophysiological characterisation of iPSC-derived human β-like cells and an SLC30A8 disease model Open
iPSC-derived human β-like cells (BLC) hold promise for both therapy and disease modelling, but their generation remains challenging and their functional analyses beyond transcriptomic and morphological assessments remain limited. Here, we …
View article: Continuous monitoring of glucose levels<i>in vivo</i>with a micro-organ based microfluidic biosensor
Continuous monitoring of glucose levels<i>in vivo</i>with a micro-organ based microfluidic biosensor Open
Continuous monitoring of glucose levels has improved diabetes therapy. Current approaches rely on enzyme-linked electrochemical probes but do not allow a fully autonomous artificial pancreas. In contrast, monitoring the activity of a few e…
View article: Extracellular electrophysiology on clonal human β-cell spheroids
Extracellular electrophysiology on clonal human β-cell spheroids Open
Pancreatic islets are important in nutrient homeostasis and improved cellular models of clonal origin may very useful especially in view of relatively scarce primary material. Close 3D contact and coupling between β-cells are a hallmark of…
View article: Fine‐Tuning the Optoelectronic and Redox Properties of an Electropolymerized Thiophene Derivative for Highly Selective OECT‐Based Zinc Detection
Fine‐Tuning the Optoelectronic and Redox Properties of an Electropolymerized Thiophene Derivative for Highly Selective OECT‐Based Zinc Detection Open
Organic mixed ionic‐electronic conductors (OMIEC) have emerged as pivotal materials in organic bioelectronics, particularly when integrated into organic electrochemical transistors (OECTs). Conducting polymer‐based devices have indeed demo…
View article: Electrophysiological characterisation of iPSC-derived human β-like cells and an<i>SLC30A8</i>disease model
Electrophysiological characterisation of iPSC-derived human β-like cells and an<i>SLC30A8</i>disease model Open
iPSC-derived human β-like cells (BLC) hold promise for both therapy and disease modelling, but their generation remains challenging and their functional analyses beyond transcriptomic and morphological assessments remain limited. Here, we …
View article: Islets-on-Chip: A Tool for Real-Time Assessment of Islet Function Prior to Transplantation
Islets-on-Chip: A Tool for Real-Time Assessment of Islet Function Prior to Transplantation Open
Islet transplantation improves metabolic control in patients with unstable type 1 diabetes. Clinical outcomes have been improving over the last decade, and the widely used beta-score allows the evaluation of transplantation results. Howeve…
View article: Towards the Integration of an Islet-Based Biosensor in Closed-Loop Therapies for Patients With Type 1 Diabetes
Towards the Integration of an Islet-Based Biosensor in Closed-Loop Therapies for Patients With Type 1 Diabetes Open
In diabetes mellitus (DM) treatment, Continuous Glucose Monitoring (CGM) linked with insulin delivery becomes the main strategy to improve therapeutic outcomes and quality of patients’ lives. However, Blood Glucose (BG) regulation with CGM…
View article: Vertical Organic Electrochemical Transistors and Electronics for Low Amplitude Micro‐Organ Signals
Vertical Organic Electrochemical Transistors and Electronics for Low Amplitude Micro‐Organ Signals Open
Electrical signals are fundamental to key biological events such as brain activity, heartbeat, or vital hormone secretion. Their capture and analysis provide insight into cell or organ physiology and a number of bioelectronic medical devic…
View article: Cellules α et β du pancréas
Cellules α et β du pancréas Open
Les diabètes sucrés sont des maladies métaboliques graves en constante augmentation. Ils sont dus à des déficits de sécrétion et d’action de l’insuline, la seule hormone qui diminue efficacement la glycémie. L’insuline est sécrétée par les…
View article: Dynamic Uni- and Multicellular Patterns Encode Biphasic Activity in Pancreatic Islets
Dynamic Uni- and Multicellular Patterns Encode Biphasic Activity in Pancreatic Islets Open
Biphasic secretion is an autonomous feature of many endocrine micro-organs to fulfill physiological demands. The biphasic activity of islet β-cells maintains glucose homeostasis and is altered in type 2 diabetes. Nevertheless, underlying c…
View article: Sodium‐Ion Selectivity Study of a Crown‐Ether‐Functionalized PEDOT Analog
Sodium‐Ion Selectivity Study of a Crown‐Ether‐Functionalized PEDOT Analog Open
An electropolymerized ion‐selective poly‐3,4‐ethylenedioxythiophene (PEDOT) analog is presented in this Communication. Poly‐(2‐phenyl‐15crown‐5‐(3,4‐ethylene‐dioxythiophene)‐amine) (PEDOT‐Crown15) showed excellent electrochemical stability…
View article: Design of Potassium‐Selective Mixed Ion/Electron Conducting Polymers
Design of Potassium‐Selective Mixed Ion/Electron Conducting Polymers Open
An approach providing cation selective PEDOT:polyelectrolyte mixed conductors is presented in this communication, based on the structural modification of this ambivalent (ionic and electronic conductive) polymer complex. First, an 18-crown…
View article: Design of Potassium‐Selective Mixed Ion/Electron Conducting Polymers
Design of Potassium‐Selective Mixed Ion/Electron Conducting Polymers Open
An approach providing cation‐selective poly‐(3,4‐ethylenedioxythiophene)(PEDOT):polyelectrolyte‐mixed conductors is presented in this communication based on the structural modification of this ambivalent (ionic and electronic conductive) p…
View article: The glutamate receptor GluK2 contributes to the regulation of glucose homeostasis and its deterioration during aging
The glutamate receptor GluK2 contributes to the regulation of glucose homeostasis and its deterioration during aging Open
View article: Functional Assessment of the Induced Pluripotent Stem Cells (iPSC)-derived β-like Cells
Functional Assessment of the Induced Pluripotent Stem Cells (iPSC)-derived β-like Cells Open
View article: Multimed: An Integrated, Multi-Application Platform for the Real-Time Recording and Sub-Millisecond Processing of Biosignals
Multimed: An Integrated, Multi-Application Platform for the Real-Time Recording and Sub-Millisecond Processing of Biosignals Open
Enhanced understanding and control of electrophysiology mechanisms are increasingly being hailed as key knowledge in the fields of modern biology and medicine. As more and more excitable cell mechanics are being investigated and exploited,…
View article: Loss-of-function mutations in ADCY3 cause monogenic severe obesity
Loss-of-function mutations in ADCY3 cause monogenic severe obesity Open
View article: A versatile electrode sorting module for MEAs: Implementation in a FPGA-based real-time system
A versatile electrode sorting module for MEAs: Implementation in a FPGA-based real-time system Open
International audience
View article: Enteral Nutrition Improves Nutritional Status, Treatment Tolerance, and Outcomes in Patients With Esophageal Cancer Undergoing Concurrent Chemoradiation Therapy: Results of a Prospective, Randomized, Controlled, Multicenter Trial (NCT 02399306)
Enteral Nutrition Improves Nutritional Status, Treatment Tolerance, and Outcomes in Patients With Esophageal Cancer Undergoing Concurrent Chemoradiation Therapy: Results of a Prospective, Randomized, Controlled, Multicenter Trial (NCT 02399306) Open
View article: A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis
A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis Open
View article: Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia
Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia Open