Marie Lenski
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View article: Development of a HPIC-ICP-MS method for the quantification and speciation of gadolinium-based contrast media in surface waters
Development of a HPIC-ICP-MS method for the quantification and speciation of gadolinium-based contrast media in surface waters Open
Gadolinium-based contrast agents (GBCAs) are analysed using a new speciation method based on HPIC-ICP-MS applicable to environmental samples. This method reconciles the factors of green chemistry, cost and efficiency.
View article: A Comparison of Molecular Techniques for Improving the Methodology in the Laboratory of Pharmacogenetics
A Comparison of Molecular Techniques for Improving the Methodology in the Laboratory of Pharmacogenetics Open
One of the most critical goals in healthcare is safe and effective drug therapy, which is directly related to an individual’s response to treatment. Precision medicine can improve drug safety in many scenarios, including polypharmacy, and …
View article: A global perspective on the status of clinical metabolomics in laboratory medicine – a survey by the IFCC metabolomics working group
A global perspective on the status of clinical metabolomics in laboratory medicine – a survey by the IFCC metabolomics working group Open
Objectives Metabolomics aims for comprehensive characterization and measurement of small molecule metabolites (<1700 Da) in complex biological matrices. This study sought to assess the current understanding and usage of metabolomics in lab…
View article: Shotgun metagenomics and systemic targeted metabolomics highlight indole-3-propionic acid as a protective gut microbial metabolite against influenza infection
Shotgun metagenomics and systemic targeted metabolomics highlight indole-3-propionic acid as a protective gut microbial metabolite against influenza infection Open
The gut-to-lung axis is critical during respiratory infections, including influenza A virus (IAV) infection. In the present study, we used high-resolution shotgun metagenomics and targeted metabolomic analysis to characterize influenza-ass…
View article: Metabolomics Provides Novel Insights into the Potential Toxicity Associated with Heated Tobacco Products, Electronic Cigarettes, and Tobacco Cigarettes on Human Bronchial Epithelial BEAS-2B Cells
Metabolomics Provides Novel Insights into the Potential Toxicity Associated with Heated Tobacco Products, Electronic Cigarettes, and Tobacco Cigarettes on Human Bronchial Epithelial BEAS-2B Cells Open
Smoking is an established risk factor for various pathologies including lung cancer. Electronic cigarettes (e-cigs) and heated tobacco products (HTPs) have appeared on the market in recent years, but their safety or, conversely, their toxi…
View article: Impact of Electronic Cigarettes, Heated Tobacco Products and Conventional Cigarettes on the Generation of Oxidative Stress and Genetic and Epigenetic Lesions in Human Bronchial Epithelial BEAS-2B Cells
Impact of Electronic Cigarettes, Heated Tobacco Products and Conventional Cigarettes on the Generation of Oxidative Stress and Genetic and Epigenetic Lesions in Human Bronchial Epithelial BEAS-2B Cells Open
Electronic cigarettes (e-cig) and heated tobacco products (HTP) are often used as smoking cessation aids, while the harm reduction effects of these alternatives to cigarettes are still the subject of controversial debate, in particular reg…
View article: Evaluation of pediatric epigenetic clocks across multiple tissues
Evaluation of pediatric epigenetic clocks across multiple tissues Open
Background Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination. Results Our study used data from seven tissue types …
View article: Development and application of a metabolomic approach for identification of early markers of toxicity of tobacco, electronic-cigarette and heated tobacco product
Development and application of a metabolomic approach for identification of early markers of toxicity of tobacco, electronic-cigarette and heated tobacco product Open
Le tabagisme est un facteur de risque établi pour diverses pathologies, dont le cancer du poumon. La cigarette électronique et le tabac chauffé sont de nouveaux produits arrivés sur le marché depuis quelques années et utilisés parfois comm…
View article: Digital competence in laboratory medicine
Digital competence in laboratory medicine Open
Objectives Even though most physicians and professionals in laboratory medicine have received basic training in statistics, experience shows that a general understanding of data analysis is not yet available on a broad scale. Therefore, da…
View article: Symposium 7 - Young Scientist Session
Symposium 7 - Young Scientist Session Open
Laboratory results are key elements in human health, participating in the diagnosis, prognosis, and treatment of different conditions.In that common objective, laboratories and clinicians are partners in patient care.But what are the win-w…
View article: Prediction of a Large-Scale Database of Collision Cross-Section and Retention Time Using Machine Learning to Reduce False Positive Annotations in Untargeted Metabolomics
Prediction of a Large-Scale Database of Collision Cross-Section and Retention Time Using Machine Learning to Reduce False Positive Annotations in Untargeted Metabolomics Open
Metabolite identification in untargeted metabolomics is complex, with the risk of false positive annotations. This work aims to use machine learning to successively predict the retention time (Rt) and the collision cross-section (CCS) of a…
View article: Aldicarb-related suicide attempt cases in North of France (2012–2021)
Aldicarb-related suicide attempt cases in North of France (2012–2021) Open
Aldicarb, a carbamate pesticide banned in France since 2008, represents a persistent risk of human poisoning. There is no up-to-date picture of aldicarb intentional poisonings associated to detailed diagnosis and clinical management of cas…
View article: Lack of direct involvement of a diazepam long-term treatment in the occurrence of irreversible cognitive impairment: a pre-clinical approach
Lack of direct involvement of a diazepam long-term treatment in the occurrence of irreversible cognitive impairment: a pre-clinical approach Open
View article: High-resolution mass spectrometry: Theoretical and technological aspects
High-resolution mass spectrometry: Theoretical and technological aspects Open
International audience
View article: Metabolomic alteration induced by psychotropic drugs: Short‐term metabolite profile as a predictor of weight gain evolution
Metabolomic alteration induced by psychotropic drugs: Short‐term metabolite profile as a predictor of weight gain evolution Open
Psychotropic drugs can induce strong metabolic adverse effects, potentially increasing morbidity and/or mortality of patients. Metabolomic profiling, by studying the levels of numerous metabolic intermediates and products in the blood, all…