Marie Schafstedde
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View article: Virtual Therapy Planning of Aortic Valve Replacement for Preventing Patient-Prosthesis Mismatch
Virtual Therapy Planning of Aortic Valve Replacement for Preventing Patient-Prosthesis Mismatch Open
Background: Recent studies suggest that any degree of patient-prosthesis mismatch (PPM) increases morbidity and mortality after surgical aortic valve replacement (SAVR). We used computational fluid dynamics simulations to test the influenc…
View article: Modelling blood flow in patients with heart valve disease using deep learning: A computationally efficient method to expand diagnostic capabilities in clinical routine
Modelling blood flow in patients with heart valve disease using deep learning: A computationally efficient method to expand diagnostic capabilities in clinical routine Open
Introduction The computational modelling of blood flow is known to provide vital hemodynamic parameters for diagnosis and treatment-support for patients with valvular heart disease. However, most diagnosis/treatment-support solutions based…
View article: Population-based reference values for 4D flow MRI derived aortic blood flow parameters
Population-based reference values for 4D flow MRI derived aortic blood flow parameters Open
Objective . This study assesses age-related differences of thoracic aorta blood flow profiles and provides age- and sex-specific reference values using 4D flow cardiovascular magnetic resonance (CMR) data. Approach . 126 volunteers (age 20…
View article: The role of androgens in pressure overload myocardial hypertrophy
The role of androgens in pressure overload myocardial hypertrophy Open
Pressure overload hypertrophy of the left ventricle is a common result of many cardiovascular diseases. Androgens show anabolic effects in skeletal muscles, but also in myocardial hypertrophy. We carefully reviewed literature regarding pos…
View article: Disease- and sex-specific differences in patients with heart valve disease: a proteome study
Disease- and sex-specific differences in patients with heart valve disease: a proteome study Open
Pressure overload in patients with aortic valve stenosis and volume overload in mitral valve regurgitation trigger specific forms of cardiac remodeling; however, little is known about similarities and differences in myocardial proteome reg…
View article: Serum dihydrotestosterone levels are associated with adverse myocardial remodeling in patients with severe aortic valve stenosis before and after aortic valve replacement
Serum dihydrotestosterone levels are associated with adverse myocardial remodeling in patients with severe aortic valve stenosis before and after aortic valve replacement Open
Serum dihydrotestosterone (DHT) levels correlated positively with the degree of hypertrophy, fibrosis, and dysfunction from cardiac magnetic resonance imaging in female and male patients with aortic valve stenosis. Left ventricular proteom…
View article: Functional hepatic deterioration determined by 13C-methacetin breath test is associated with impaired hemodynamics and late Fontan failure in adults
Functional hepatic deterioration determined by 13C-methacetin breath test is associated with impaired hemodynamics and late Fontan failure in adults Open
Background Despite improved survival a substantial number of Fontan patients eventually develop late failure. Fontan-associated liver disease (FALD) is the most frequent end-organ dysfunction. Although impaired hemodynamics and Fontan fail…
View article: Virtual treatment planning in three patients with univentricular physiology using computational fluid dynamics—Pitfalls and strategies
Virtual treatment planning in three patients with univentricular physiology using computational fluid dynamics—Pitfalls and strategies Open
Background Uneven hepatic venous blood flow distribution (HFD) to the pulmonary arteries is hypothesized to be responsible for the development of intrapulmonary arteriovenous malformations (PAVM) in patients with univentricular physiology.…
View article: A Multimodal Score Accurately Classifies Fontan Failure and Late Mortality in Adult Fontan Patients
A Multimodal Score Accurately Classifies Fontan Failure and Late Mortality in Adult Fontan Patients Open
Objectives Despite the outstanding success of the Fontan operation, it is a palliative procedure and a substantial number of patients experience late failure of the Fontan circulation. Clinical presentation and hemodynamic phenotypes of Fo…
View article: Training Data for Predicting Hemodynamics in Aortic Stenosis Patients
Training Data for Predicting Hemodynamics in Aortic Stenosis Patients Open
This dataset has been derived from computed-tomography based CFD simulations of the human aorta in patients with aortic valve stenosis. A total of 309 cases is presented, which are based on 103 patients. Each patient was simulated with thr…
View article: Morphologic Alterations Precede Functional Hepatic Impairment as Determined by 13C-Methacetin Liver Function Breath Test in Adult Fontan Patients
Morphologic Alterations Precede Functional Hepatic Impairment as Determined by 13C-Methacetin Liver Function Breath Test in Adult Fontan Patients Open
Objectives: Fontan-associated liver disease (FALD) is the most common end-organ dysfunction affecting up to 70–80% of the Fontan population. The clinical significance of FALD is incompletely understood and no unambiguous correlation betwee…
View article: Computed Tomography-Based Assessment of Transvalvular Pressure Gradient in Aortic Stenosis
Computed Tomography-Based Assessment of Transvalvular Pressure Gradient in Aortic Stenosis Open
Background: In patients with aortic stenosis, computed tomography (CT) provides important information about cardiovascular anatomy for treatment planning but is limited in determining relevant hemodynamic parameters such as the transvalvul…
View article: Persisting and reoccurring cyanosis after Fontan operation is associated with increased late mortality
Persisting and reoccurring cyanosis after Fontan operation is associated with increased late mortality Open
OBJECTIVES The Fontan operation aims at reducing cyanosis and cardiac volume overload in patients with complex univentricular heart malformations. However, persisting or reoccurring cyanosis is frequently observed. We sought to systematica…
View article: Can Left Atrioventricular Valve Reduction Index (LAVRI) Predict the Surgical Strategy for Repair of Atrioventricular Septal Defect?
Can Left Atrioventricular Valve Reduction Index (LAVRI) Predict the Surgical Strategy for Repair of Atrioventricular Septal Defect? Open
Despite improved survival, surgical treatment of atrioventricular septal defect (AVSD) remains challenging. The optimal technique for primary left atrioventricular valve (LAVV) repair and prediction of suitability for biventricular approac…
View article: Hemodynamic Modeling of Biological Aortic Valve Replacement Using Preoperative Data Only
Hemodynamic Modeling of Biological Aortic Valve Replacement Using Preoperative Data Only Open
Objectives: Prediction of aortic hemodynamics after aortic valve replacement (AVR) could help optimize treatment planning and improve outcomes. This study aims to demonstrate an approach to predict postoperative maximum velocity, maximum p…