Marie Therese Manipadam

Dose-Dense Docetaxel-Cyclophosphamide and Epirubicin-Cisplatin(ddDCEP): Analysis of an alternative platinum-containing regimen in 116 patients with early triple negative breast cancer Open

Ashish Singh, Josh Thomas Georgy, Anjana Joel, Divya Bala Thumaty, Ajoy Oommen John , et al. · 2023

We assessed the efficacy, tolerability, and cost-effectiveness of a novel neoadjuvant regimen comprising docetaxel-cyclophosphamide alternating with epirubicin-cisplatin (ddDCEP) administered biweekly for 16 weeks in 116 patients with earl…

Dose-Dense Docetaxel-Cyclophosphamide and Epirubicin-Cisplatin(ddDCEP): Analysis of an Alternative Platinum-Containing Regimen in 116 Patients with Early Triple Negative Breast Cancer Open

Ashish Singh, Josh Thomas Georgy, Anjana Joel, Divya Bala Thumaty, Ajoy Oommen John , et al. · 2023

We assessed the efficacy, tolerability, and cost-effectiveness of a novel neoadjuvant regimen comprising docetaxel-cyclophosphamide alternating with epirubicin-cisplatin (ddDCEP) administered biweekly for 16 weeks in 116 patients with earl…

Preoperative dose-dense docetaxel and cyclophosphamide alternating with epirubicin and cisplatin(ddDCEP): an effective, novel way of incorporating platinum in the treatment of early TNBC Open

Ashish Singh, Josh Thomas Georgy, Divya Bala Thumaty, Ajoy Oommen John, Nithya Ramnath , et al. · 2023

Purpose The addition of carboplatin has improved pathological complete response (PCR) and event-free survival (EFS) and is becoming a new standard of care for early triple-negative breast cancer (TNBC). However, this comes at the expense o…

Utility of reverse transcriptase – Multiplex ligation-dependant probe amplification (RT-MLPA) in the molecular classification of Diffuse Large B cell lymphoma (DLBCL) by cell-of-origin (COO) Open

Nicholas D’Cunha, Dhananjayan Sakhti, Elanthendral Sigamani, Jagan Chandramohan, Anu Korula , et al. · 2022

Classifying diffuse large B cell lymphomas, not otherwise specified (DLBCL, NOS), is based on their cell-of-origin (COO) which is included in the WHO classification (2016), is essential to characterize them better in context of prognostica…

Subclonal evolution in the mutational landscape of early Triple negative breast cancer (TNBC) on multi-agent chemotherapy: Comparison of Pre- And Post-Neoadjuvant Chemotherapy (NAC) Samples Of TNBC Patients With Residual Disease Open

Ashish Singh, Josh Thomas Georgy, Sakthi Dhananjayan, Elanthendral Sigamani, Ajoy Oommen John , et al. · 2022

Background Triple-negative breast cancer (TNBC) with residual disease post chemotherapy, have increased chance of relapse and lower survival with varying degree of pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). …

Preoperative dose-dense docetaxel and cyclophosphamide alternating with epirubicin and cisplatin(ddDCEP): an effective, novel way of incorporating platinum in the treatment of early TNBC Open

Ashish Singh, Josh Thomas Georgy, Ajoy Oommen John, Divya Bala Thumaty, Anjana Joel , et al. · 2022

Purpose Carboplatin-containing treatment regimens in early TNBC have shown improved pCR(pathological complete response) and better EFS(event-free survival) but at the expense of increased toxicity, often leading to compromised delivery of …

Ovarian Teratoma Causing Oncogenic Osteomalacia: An Instance of Serendipity Open

Jinson Paul, Antresa Jose, Beena Kingsbury, Marie Therese Manipadam, Nitin Kapoor , et al. · 2022

Comparison of primary follicular lymphoma of gastrointestinal tract and secondary involvement Open

Dipti Masih, Jagan Chandramohan, Elanthenral Sigamani, N A Fouzia, Anu Korula , et al. · 2022

Primary follicular lymphoma of the gut (PFL-GI) is a rare entity. This study aims to compare the clinicopathologic features of PFL-GI with cases of gastrointestinal involvement by disseminated nodal follicular lymphoma. This is a retrospec…

Composite Pheochromocytoma—A Rare Clinical Entity: A Case Series Open

Pushkar Sharma, Paul Jacob, Santosh Raj, Elanthenral Sigamani, Marie Therese Manipadam · 2021

Background: Composite pheochromocytoma is a rare entity with tumor comprising both pheochromocytoma and neuroblastic elements.The clinical outcome of such a composite tumor is not fully understood.In this case series, we report three cases…

Clinical Profile and Mutations Associated with Multiple Endocrine Neoplasia-Type1 (MEN1) and Their First-Degree Relatives at Risk of Developing MEN1: A Prospective Study Open

Hesarghatta Shyamasunder Asha, Rekha Pai, Hemalatha Ramamoorthy, Dhananjayan Sakhti, Marie Therese Manipadam , et al. · 2021

Multiple Endocrine Neoplasia type-1 (MEN1) is an autosomal dominant disorder with a combined occurrence of tumours of parathyroid glands, pancreatic islets, and anterior pituitary. About 90% of these patients carry mutations in the MEN1 ge…

Neoadjuvant chemotherapy with biosimilar trastuzumab in human epidermal growth factor receptor 2 overexpressed non-metastatic breast cancer: patterns of use and clinical outcomes in India Open

Anjana Joel, Josh Thomas Georgy, Divya Bala Thumaty, Ajoy Oommen John, Raju Titus Chacko , et al. · 2021

Access to anti-HER2 therapy in the treatment of non-metastatic HER2-positive breast cancer in resource-constrained settings has improved significantly with the availability of the biosimilar trastuzumab. Imbalances in patient profiles at b…

Mutation Profile in BCR-ABL1-Negative Myeloproliferative Neoplasms Open

Madhavi Maddali, Uday Kulkarni, Niveditha Ravindra, Arun Kumar Arunachalam, Arvind Venkatraman , et al. · 2021

Objective/Background: Recurrent somatic mutations in the JAK2, calreticulin ( CALR ), and the MPL genes are described as drivers of BCR-ABL1 -negative myeloproliferative neoplasms (MPN) that includes polycythemia vera (PV), essential throm…

Pathological response and clinical outcomes in operable triple-negative breast cancer with cisplatin added to standard neoadjuvant chemotherapy Open

Ashish Singh, Josh Thomas Georgy, Ajoy Oommen John, Anjana Joel, Divya Bala Thumaty , et al. · 2021

The addition of cisplatin to neoadjuvant chemotherapy with anthracycline and taxane in TNBC was tolerable and produced a high rate of pathological complete response. Cisplatin added to standard chemotherapy in patients with locally advance…

Parathyroid lipohyperplasia – a rare and difficult to localize entity Open

Remya Rajan, Marie Therese Manipadam, Santhosh Raj, Deepak Thomas Abraham, Nitin Kapoor , et al. · 2021

INTRODUCTION Primary hyperparathyroidism (PHPT) is estimated to be the third most commonly diagnosed endocrine disorder.[1] The clinical presentation is usually variable and ranges from an asymptomatic presentation to florid manifestations…

Calreticulin immunohistochemistry in myeloproliferative neoplasms - evolution of a new cost-effective diagnostic tool: a retrospective study with histological and molecular correlation Open

Sanjeet Roy, Marie Therese Manipadam, Poonkuzhali Balasubramanian · 2021

Anti-CAL2 immunohistochemistry is a specific and a sensitive marker to detect CALR mutation. Its' cost effectiveness and fast results are quite advantageous as compared to molecular analysis.

Myelofibrosis and Pancytopenia Associated With Primary Hyperparathyroidism Open

Remya Rajan, Immanuel Paul, Kripa Elizabeth Cherian, Anu Korula, Julie Hephzibah , et al. · 2020

Factors affecting survival in childhood Hodgkin lymphoma Open

Deepthi Boddu, Rikki R. John, Sidharth Totadri, Leenu L. Joseph, Hema Ns , et al. · 2020

Intrathyroid Parathyroid Adenomas-Uncommon Tumours at Unusual Sites: A Cross-sectional Study Open

Jagan Chandramohan, Elanthenral Sigamani, Deepak Thomas Abraham, Paul Mazhuvanchary Jacob, Anish Jacob Cherian , et al. · 2020

Introduction: Ectopic Intrathyroid Parathyroid Adenomas (ITPAs) are rare and known to pose preoperative and intraoperative diagnostic challenges in localisation, resulting in failure of parathyroid surgery. The common histopathological fea…

Burden of diabetes among patients with tuberculosis: 10-year experience from a tertiary care referral teaching hospital in South India Open

Devasahayam Jesudas Christopher, Lakshmanan Jeyaseelan, Joy Sarojini Michael, Balaji Veeraraghavan, Marie Therese Manipadam , et al. · 2020

Over a 10-year study period, 24% of the TB patients were diabetic, nearly half were detected at the time of TB diagnosis. There may be a good case for screening all TB patients for DM.

Clinicopathologic study of Kikuchi’s disease in children in a tertiary hospital in South India Open

Anu Punnen, Kanagalakshmi, Marie Therese Manipadam, Valsan Philip Verghese, Leni Grace Mathew , et al. · 2019

Background: The aim of this study was to evaluate the clinical and laboratory characteristics, treatment modalities and outcome of children with Kikuchi’s disease.Methods: A retrospective cross-sectional study was conducted among all child…

Peripheral T cell lymphoma Open

Sandeep Nemani, Anu Korula, Bhumi Agrawal, M. Kavitha, Marie Therese Manipadam , et al. · 2018

Background & objectives: Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of non-Hodgkin's lymphomas (NHLs), with universally poor outcome. This study was undertaken to provide data on demographics and outcomes of patients wit…

Malignant rhabdoid tumour of the neck in a neonate Open

Mintoo Tergestina, Benjamin Ross, Marie Therese Manipadam, Manish Kumar · 2018

Fetal neck masses are rare, and present a challenge antenatally, during delivery and in making a diagnosis. In this report, we detail the presentation of a neonate with a neck mass diagnosed in the third trimester. The baby was delivered b…

A rare case of splenic diffuse red pulp small B-cell lymphoma (SDRPL): a review of the literature on primary splenic lymphoma with hairy cells Open

Tanush Vig, Thomas Alex Kodiatte, Marie Therese Manipadam, Fouzia Nambiathayil Aboobacker · 2018

Outcome of Treatment for Medullary Thyroid Carcinoma—a Single Centre Experience Open

Anish Jacob Cherian, Pooja Ramakant, Rekha Pai, Marie Therese Manipadam, S. Elanthenral , et al. · 2017

Re-operative Surgery for Pheochromocytoma-Paraganglioma: Analysis of 13 Cases from a Single Institution Open

Dhiraj John Sonbare, Deepak Thomas Abraham, Simon Rajaratnam, Nihal Thomas, Marie Therese Manipadam , et al. · 2017

Clinicopathological Study of 18 Cases of Inflammatory Myofibroblastic Tumors with Reference to ALK-1 Expression: 5-Year Experience in a Tertiary Care Center Open

Ramesh Babu Telugu, Anne Jennifer Prabhu, Nobin Babu Kalappurayil, John Mathai, Birla Roy Gnanamuthu , et al. · 2017

Overall, ALK-1 protein was expressed in 55.6% of inflammatory myofibroblastic tumors. There was no statistically significant correlation between ALK-1 expression, tumor type, recurrence and metastasis. However, ALK-1 immunohistochemistry i…

The t(8;14)(q24.1;q32) and its variant translocations Open

Meenu Angi, Vandana Kamath, S Yuvarani, Jagdish Prasad Meena, Usha Sitaram , et al. · 2017

Background: The t(8;14)(q24.1;q32) and its variants – the t(2;8)(p12;q24.1) and t(8;22)(q24.1; q11.2) are associated with B-cell neoplasia and result in MYC/immunoglobulin (IG) gene rearrangement. Patients and methods: We correlated the cy…

Radiotherapy in Phyllodes Tumour Open

Sunitha Susan Varghese, Balukrishna Sasidharan, Marie Therese Manipadam, M. J. Paul, Selvamani Backianathan · 2017

Surgical resection with adequate margins (>1 cm) gave excellent local control in B and BL tumours. For patients with BL PT, local radiotherapy is useful, if margins are close or positive even after the best surgical resection. There is a t…

Automated Segmentation of Nuclei in Breast Cancer Histopathology Images Open

Maqlin Paramanandam, Michael L. O’Byrne, Bidisha Ghosh, Joy Mammen, Marie Therese Manipadam , et al. · 2016

The process of Nuclei detection in high-grade breast cancer images is quite challenging in the case of image processing techniques due to certain heterogeneous characteristics of cancer nuclei such as enlarged and irregularly shaped nuclei…

Is TIRADS a practical and accurate system for use in daily clinical practice? Open

Anuradha Chandramohan, Abhishek Khurana, B. T. Pushpa, Marie Therese Manipadam, Dukhabandhu Naik , et al. · 2016

Aim: To assess the positive predictive value (PPV) and inter-observer agreement of Thyroid Imaging Reporting and Data System (TIRADS) as described by Kwak et al. Materials and Methods: This was a prospective study wherein ultrasound was pe…

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