Explanipedia

Environmental Risk Assessment of Time-Variable Toxicant Exposure with Toxicokinetic–Toxicodynamic Modeling of Sublethal Endpoints and Moving Time Windows: A Case Study with <i>Ceriodaphnia dubia</i> Open

C. Romoli, Marie Trijau, E. Müller, Liubov Zakharova, Roland Kuhl , et al. · 2024

Toxicokinetic–toxicodynamic (TKTD) modeling has received increasing attention in terms of the regulatory environmental risk assessment of chemicals. This type of mechanistic model can integrate all available data from individual-level bioa…

Development of a mechanistic model for analyzing avian reproduction data for pesticide risk assessment Open

Marie Trijau, Benoît Goussen, Richard A. Brain, Jonathan D. Maul, Nika Galić · 2023

Mechanistic effect models are increasingly recommended as tools for refining evaluations of risk from exposure to pesticides. In the context of bird and mammal risk assessments, DEB-TKTD models have been recommended for characterizing subl…

The application and limitations of exposure multiplication factors in sublethal effect modelling Open

Neil Sherborne, Tjalling Jager, Benoît Goussen, Marie Trijau, Roman Ashauer · 2022

Thanks to growing interest and research in the field, toxicokinetic–toxicodynamic (TKTD) models are close to realising their potential in environmental risk assessment (ERA) of chemicals such as plant protection products. A fundamental app…

rDEBtktd, an R-package for analysis and forward-prediction of sublethal effects Open

Marie Trijau, Benoît Goussen, André Gergs, Sandrine Charles · 2021

Environmental Risk Assessment (ERA) of chemicals is based on standard laboratory toxicity tests with living organisms which ensure controlled experimental conditions and reproducibility. These toxicity tests are usually carried out under c…

Considerations for using reproduction data in toxicokinetic–toxicodynamic modeling Open

Tjalling Jager, Marie Trijau, Neil Sherborne, Benoît Goussen, Roman Ashauer · 2021

Toxicokinetic–toxicodynamic (TKTD) modeling is essential to make sense of the time dependence of toxic effects, and to interpret and predict consequences of time-varying exposure. These advantages have been recognized in the regulatory are…

Considerations for using reproduction data in toxicokinetic-toxicodynamic modelling Open

Tjalling Jager, Marie Trijau, Neil Sherborne, Benoît Goussen, Roman Ashauer · 2021

Toxicokinetic-toxicodynamic (TKTD) modelling is essential to make sense of the time dependence of toxic effects, and to interpret and predict consequences of time-varying exposure. These advantages have been recognised in the regulatory ar…

Epigenetic modifications as a molecular mechanism for transgenerational effects in Daphnia exposed to ionising radiation Open

Marie Trijau, Jana Asselman, Olivier Armant, Christelle Adam‐Guillermin, Karel De Schamphelaere , et al. · 2019

International audience

Approche moléculaire et mécaniste de la réponse transgénérationnelle lors d'une irradiation gamma chronique chez le cladocère Daphnia magna Open

Marie Trijau · 2018

In order to durably protect ecosystems facing planned or accidental releases of radionuclides, the long-term impact of organism exposure to ionizing radiation must be studied on a multigenerational scale. The aim of this PhD is to improve …

Molecular and mechanistic studies of the transgenerational response during a chronic gamma irradiation in the cladoceran Daphnia magna Open

Marie Trijau · 2018

Afin de protéger durablement les écosystèmes face aux rejets planifiés ou accidentels de radionucléides dans l’environnement, il est essentiel d’évaluer l’impact de l’exposition des organismes aux radiations ionisantes sur le long terme, à…

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