Explanipedia

Newly Onset Dyspnea During Pregnancy Open

Marie Vermant, Valerie Van Ballaer, Tine Follet, Eveline Claeys, Samuel De Bontridder , et al. · 2025

Distinct Morphological Types of Small Airway Obstructions in Smokers with Emphysema and End-Stage Chronic Obstructive Pulmonary Disease Open

Vincent Geudens, Charlotte De Fays, Lynn Willems, Astrid Vermaut, Gitte Aerts , et al. · 2025

Rationale: The precise nature of small airway obstructions in chronic obstructive pulmonary disease (COPD) remains poorly understood, especially at early disease stages. Objectives: This study aimed to characterize small airw…

Mortality Outcomes and Angiotensin-Converting Enzyme Inhibitor Use in Patients With Idiopathic Pulmonary Fibrosis Open

Burcu Özaltin, Robert Chapman, Tine Follet, Marie Vermant, Muhammad Qummer Ul Arfeen , et al. · 2025

In this study, ACE inhibitor therapy was independently associated with reduced all-cause mortality in IPF but not in COPD. Prospective trials are warranted to confirm these findings in IPF populations.

A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases Open

Yumin Zheng, Jonas C. Schupp, Taylor Adams, Gérémy Clair, A. Justet , et al. · 2025

Human diseases are characterized by intricate cellular dynamics. Single-cell transcriptomics provides critical insights, yet a persistent gap remains in computational tools for detailed disease progression analysis and targeted in silico d…

Computational fluid dynamics of small airway disease in chronic obstructive pulmonary disease Open

Y. Khaled Mohamed Elm Mohamady, Vincent Geudens, Charlotte De Fays, Marta Zapata, Omar Hagrass , et al. · 2025

Supported by the KU Leuven (C16/19/005).

Lung ultrasound outperforms symptom-based screening to detect interstitial lung disease associated with rheumatoid arthritis Open

Marie Vermant, Alexandros Kalkanis, Joseph Jacob, Tinne Goos, Emanuela Elsa Cortesi , et al. · 2025

Objectives Interstitial lung disease associated with rheumatoid arthritis (RA-ILD) is linked to high mortality. Currently, effective screening tools are lacking. We assessed the role of symptoms and lung ultrasound (LUS) as potential scree…

Ventilatory capacity in CLAD is driven by dysfunctional airway structure Open

Pieterjan Kerckhof, Gene Philip Louie Ambrocio, Hanne Beeckmans, Janne Kaes, Vincent Geudens , et al. · 2024

Unagi: Deep Generative Model for Deciphering Cellular Dynamics and In-Silico Drug Discovery in Complex Diseases Open

Yumin Zheng, Jonas C. Schupp, Taylor Adams, Gérémy Clair, A. Justet , et al. · 2023

Human diseases are characterized by intricate cellular dynamics. Single-cell sequencing provides critical insights, yet a persistent gap remains in computational tools for detailed disease progression analysis and targeted in-silico drug i…

ERS International Congress 2023: highlights from the Interstitial Lung Diseases Assembly Open

Laura Fabbri, Julien Guiot, Marie Vermant, Ewa Miądlikowska, Deborah Dos Reis Estrella , et al. · 2023

This article summarises a selection of scientific highlights in the field of interstitial lung diseases (ILDs) presented at the International Congress of the European Respiratory Society in 2023. Translational and clinical studies focused …

Mortality surrogates in combined pulmonary fibrosis and emphysema Open

An Zhao, Eyjólfur Gudmundsson, Nesrin Moğulkoç, Coline van Moorsel, Tamera J. Corte , et al. · 2023

Background Idiopathic pulmonary fibrosis (IPF) with coexistent emphysema, termed combined pulmonary fibrosis and emphysema (CPFE) may associate with reduced forced vital capacity (FVC) declines compared to non-CPFE IPF patients. We examine…

Mucosal immune alterations at the early onset of tissue destruction in chronic obstructive pulmonary disease Open

Charlotte de Fays, Vincent Geudens, Iwein Gyselinck, Pieterjan Kerckhof, Astrid Vermaut , et al. · 2023

Rationale COPD is characterized by chronic airway inflammation, small airways changes, with disappearance and obstruction, and also distal/alveolar destruction (emphysema). The chronology by which these three features evolve with altered m…

Ultrasonographic Presentation and Anatomic Distribution of Lung Involvement in Patients with Rheumatoid Arthritis Open

Marie Vermant, Alexandros Kalkanis, Tinne Goos, Heleen Cypers, Nico De Crem , et al. · 2023

Background: Rheumatoid arthritis (RA) is a chronic auto-immune disease, typically affecting the joints, which can also present with lung involvement (pleuritis, interstitial lung disease, pulmonary nodules, etc.). Lung ultrasound (LUS) is …

Intrafamilial Correlation and Variability in the Clinical Evolution of Pulmonary Fibrosis Open

Tinne Goos, Adriana Dubbeldam, Marie Vermant, Stefan Gogaert, Laurens De Sadeleer , et al. · 2023

COVID-19 progression in hospitalized patients using follow-up in vivo CT and ex vivo microCT Open

Vincent Geudens, Jan Van Slambrouck, Gitte Aerts, Lynn Willems, Tinne Goos , et al. · 2023

COVID-19-ARDS and subsequent pulmonary fibrosis alters lung architecture and airway morphology which is described using in vivo CT, ex vivo microCT, and histology.

Mortality surrogates in combined pulmonary fibrosis and emphysema Open

An Zhao, Eyjólfur Gudmundsson, Nesrin Moğulkoç, Coline van Moorsel, Tamera J. Corte , et al. · 2023

Background Idiopathic pulmonary fibrosis (IPF) with co-existent emphysema, termed combined pulmonary fibrosis and emphysema (CPFE) may be associated with reduced FVC decline compared to non-CPFE IPF patients. We examined associations betwe…

Delineating associations of progressive pleuroparenchymal fibroelastosis in patients with pulmonary fibrosis Open

Eyjólfur Gudmundsson, An Zhao, Nesrin Moğulkoç, Frouke van Beek, Tinne Goos , et al. · 2023

Background Computer quantification of baseline computed tomography (CT) radiological pleuroparenchymal fibroelastosis (PPFE) associates with mortality in idiopathic pulmonary fibrosis (IPF). We examined mortality associations of longitudin…

Are genes the missing link to detect and prognosticate RA-ILD? Open

Marie Vermant, Tinne Goos, Stefan Gogaert, Diederik De Cock, Patrick Verschueren , et al. · 2022

Airway measurement by refinement of synthetic images improves mortality prediction in idiopathic pulmonary fibrosis Open

Ashkan Pakzad, Moucheng Xu, Wing Keung Cheung, Marie Vermant, Tinne Goos , et al. · 2022

Several chronic lung diseases, like idiopathic pulmonary fibrosis (IPF) are characterised by abnormal dilatation of the airways. Quantification of airway features on computed tomography (CT) can help characterise disease progression. Physi…

Airway Measurement by Refinement of Synthetic Images Improves Mortality Prediction in Idiopathic Pulmonary Fibrosis Open

Ashkan Pakzad, Moucheng Xu, Wing Keung Cheung, Marie Vermant, Tinne Goos , et al. · 2022

Several chronic lung diseases, like idiopathic pulmonary fibrosis (IPF) are characterised by abnormal dilatation of the airways. Quantification of airway features on computed tomography (CT) can help characterise disease severity and progr…

Progression in the Management of Non-Idiopathic Pulmonary Fibrosis Interstitial Lung Diseases, Where Are We Now and Where We Would Like to Be Open

Tinne Goos, Laurens De Sadeleer, Jonas Yserbyt, Geert M. Verleden, Marie Vermant , et al. · 2021

A significant proportion of patients with interstitial lung disease (ILD) may develop a progressive fibrosing phenotype characterized by worsening of symptoms and pulmonary function, progressive fibrosis on chest computed tomography and in…

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