Marieke Begemann
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View article: Association between the exposome score for schizophrenia and functioning in remitted first-episode psychosis: results from the HAMLETT study
Association between the exposome score for schizophrenia and functioning in remitted first-episode psychosis: results from the HAMLETT study Open
This study independently replicated the finding that ES-SCZ predicts general functioning in FEP, showing its potential for forecasting functioning in remitted FEP patients.
View article: The Effects of Antipsychotic Dose Reduction on Movement Disorders and Cardiometabolic Indices in Patients Remitted from a First Episode of Psychosis
The Effects of Antipsychotic Dose Reduction on Movement Disorders and Cardiometabolic Indices in Patients Remitted from a First Episode of Psychosis Open
Background and Hypothesis The extent to which tapering antipsychotic (AP) attenuates AP-related movement disorders and cardiometabolic dysfunction remains unclear. We aim to investigate the long-term effects of AP-dose reduction on these a…
View article: Risk of relapse during tapering of antipsychotic medication after a first psychotic episode: association with D2 receptor affinity but not with tapering speed
Risk of relapse during tapering of antipsychotic medication after a first psychotic episode: association with D2 receptor affinity but not with tapering speed Open
While antipsychotic maintenance treatment effectively prevents relapse after a first psychotic episode, many remitted antipsychotic users wish to reduce or discontinue their medication, due to side effects, long‐term health concerns, stigm…
View article: Psychological Adverse Effects of Antipsychotic Medication after Remission of First Episode Psychosis: a HAMLETT Ecological Momentary Assessment Study
Psychological Adverse Effects of Antipsychotic Medication after Remission of First Episode Psychosis: a HAMLETT Ecological Momentary Assessment Study Open
Introduction Current evidence on psychological adverse effects (AEs) of antipsychotic medication after remission of First Episode Psychosis (FEP), and the impact of these AEs on daily life, is limited. Objectives To investigate serial cros…
View article: Dopamine D<sub>2/3</sub>R availability after discontinuation of antipsychotic treatment: a [<sup>11</sup>C]raclopride PET study in remitted first-episode psychosis patients
Dopamine D<sub>2/3</sub>R availability after discontinuation of antipsychotic treatment: a [<sup>11</sup>C]raclopride PET study in remitted first-episode psychosis patients Open
Background After remission of a first-episode psychosis (FEP), antipsychotic discontinuation is associated with an increased risk of relapse compared to maintenance treatment. We studied short and longer-term effects of discontinuation of …
View article: Cumulative exposure to childhood adversity and risk of adult psychosis: a dose–response meta-analysis
Cumulative exposure to childhood adversity and risk of adult psychosis: a dose–response meta-analysis Open
Background Past meta-analyses have confirmed robust associations between childhood traumatic experiences and the risk of psychosis. However, the dose–response relationship between cumulative adversity exposure and psychosis risk observed i…
View article: Psychological side effects of antipsychotic medication after remission from first-episode psychosis: a HAMLETT ecological momentary assessment study
Psychological side effects of antipsychotic medication after remission from first-episode psychosis: a HAMLETT ecological momentary assessment study Open
Background Evidence on psychological side effects (PSEs) of antipsychotic medication after remission from first-episode psychosis (FEP), and their momentary impact on daily life, is limited. This study examined how Dopamine-2 (D 2 ) affini…
View article: Associations between momentary mental states and concurrent social functioning after remission from first episode psychosis: A HAMLETT ecological momentary assessment study
Associations between momentary mental states and concurrent social functioning after remission from first episode psychosis: A HAMLETT ecological momentary assessment study Open
Self-reported PEs, momentary motivation/drive and general affective symptoms are associated with daily-life functioning after remission from FEP. Retrospective observer-rated and momentary self-report assessment methods do not measure the …
View article: Psychiatrists effect on positive symptom severity and daily functioning during pharmacotherapy for first-episode psychosis patients
Psychiatrists effect on positive symptom severity and daily functioning during pharmacotherapy for first-episode psychosis patients Open
View article: The association of prolactin and gonadal hormones with cognition and symptoms in men with schizophrenia spectrum disorder: Divergent effects of testosterone and estrogen
The association of prolactin and gonadal hormones with cognition and symptoms in men with schizophrenia spectrum disorder: Divergent effects of testosterone and estrogen Open
The results suggest positive associations between testosterone and cognition and symptoms in men with SSD, while suggesting that high prolactin levels could relate to lower testosterone levels, possibly worsening cognition and symptoms in …
View article: Response to psychotic experiences: Impact of personality traits on perceived levels of distress
Response to psychotic experiences: Impact of personality traits on perceived levels of distress Open
The level of Openness to Experiences influences the perceived distress from (subclinical) positive symptoms in both patients and siblings.
View article: Psychiatrists effect on symptom severity during pharmacotherapy for first episode psychosis patients
Psychiatrists effect on symptom severity during pharmacotherapy for first episode psychosis patients Open
Clinical outcome after a first episode psychosis (FEP) is heterogeneous. Many patient-related factors such as gender and comorbidity have been studied to predict outcome. However, psychiatrist-related factors, such as the therapeutic relat…
View article: Personal recovery in first-episode psychosis: Beyond clinical and functional recovery
Personal recovery in first-episode psychosis: Beyond clinical and functional recovery Open
View article: What Do Four Decades of Research Tell Us About the Association between Childhood Adversity and Psychosis: An Updated and Extended Multi-Level Meta-Analysis
What Do Four Decades of Research Tell Us About the Association between Childhood Adversity and Psychosis: An Updated and Extended Multi-Level Meta-Analysis Open
View article: Comparing Early Tapering of Antipsychotic Medication to 12 Months Maintenance Treatment after Remission of a First Psychotic Episode
Comparing Early Tapering of Antipsychotic Medication to 12 Months Maintenance Treatment after Remission of a First Psychotic Episode Open
View article: ALTERED GRAY MATTER STRUCTURAL COVARIANCE NETWORKS IN TRAUMA-EXPOSED PATIENTS WITH RECENT-ONSET PSYCHOSIS
ALTERED GRAY MATTER STRUCTURAL COVARIANCE NETWORKS IN TRAUMA-EXPOSED PATIENTS WITH RECENT-ONSET PSYCHOSIS Open
View article: Addressing the Evidence to Practice Gap: What to Expect From International Antipsychotic Dose Reduction Studies in the Tapering Anti-Psychotics and Evaluating Recovery Consortium
Addressing the Evidence to Practice Gap: What to Expect From International Antipsychotic Dose Reduction Studies in the Tapering Anti-Psychotics and Evaluating Recovery Consortium Open
View article: The association of childhood trauma with depressive and negative symptoms in recent onset psychosis: a sex-specific analysis
The association of childhood trauma with depressive and negative symptoms in recent onset psychosis: a sex-specific analysis Open
Background Childhood trauma may impact the course of schizophrenia spectrum disorders (SSD), specifically in relation to the increased severity of depressive or negative symptoms. The type and impact of trauma may differ between sexes. In …
View article: Cholinesterase Inhibitors for Treatment of Psychotic Symptoms in Alzheimer Disease and Parkinson Disease
Cholinesterase Inhibitors for Treatment of Psychotic Symptoms in Alzheimer Disease and Parkinson Disease Open
Importance Psychotic symptoms greatly increase the burden of disease for people with neurodegenerative disorders and their caregivers. Cholinesterase inhibitors (ChEIs) may be effective treatment for psychotic symptoms in these disorders. …
View article: Social Deafferentation and the Relation Between Loneliness and Hallucinations
Social Deafferentation and the Relation Between Loneliness and Hallucinations Open
Background and Hypothesis The social deafferentation hypothesis (SDA) has been proposed as an explanatory mechanism of hallucinations, based on the theory that social withdrawal triggers the initial phase of schizophrenia. The current stud…
View article: Personal Recovery in First-Episode Psychosis Beyond Clinical and Functional Recovery
Personal Recovery in First-Episode Psychosis Beyond Clinical and Functional Recovery Open
View article: Cholinesterase Inhibitors for Psychotic Symptoms in Alzheimer's Disease, Parkinson's Disease and Dementia with Lewy Bodies: An Individual Participant Data Meta-Analysis
Cholinesterase Inhibitors for Psychotic Symptoms in Alzheimer's Disease, Parkinson's Disease and Dementia with Lewy Bodies: An Individual Participant Data Meta-Analysis Open
View article: Lower fractional anisotropy without evidence for neuro-inflammation in patients with early-phase schizophrenia spectrum disorders
Lower fractional anisotropy without evidence for neuro-inflammation in patients with early-phase schizophrenia spectrum disorders Open
View article: Antipsychotic maintenance treatment versus dose reduction: how the story continues
Antipsychotic maintenance treatment versus dose reduction: how the story continues Open
View article: Occurrence and phenomenology of hallucinations in the general population: A large online survey
Occurrence and phenomenology of hallucinations in the general population: A large online survey Open
View article: Editorial: new directions in hallucination research
Editorial: new directions in hallucination research Open
View article: The neurobiological characterization of distinct cognitive subtypes in early-phase schizophrenia-spectrum disorders
The neurobiological characterization of distinct cognitive subtypes in early-phase schizophrenia-spectrum disorders Open
View article: Auditory verbal hallucinations and childhood trauma subtypes across the psychosis continuum: a cluster analysis
Auditory verbal hallucinations and childhood trauma subtypes across the psychosis continuum: a cluster analysis Open
Introduction: A strong link between voice-hearing experience and childhood trauma has been established. The aim of this study was to identify whether there were unique clusters of childhood trauma subtypes in a sample across the cli…
View article: Longitudinal clinical and functional outcome in distinct cognitive subgroups of first-episode psychosis: a cluster analysis
Longitudinal clinical and functional outcome in distinct cognitive subgroups of first-episode psychosis: a cluster analysis Open
Background Cognitive deficits may be characteristic for only a subgroup of first-episode psychosis (FEP) and the link with clinical and functional outcomes is less profound than previously thought. This study aimed to identify cognitive su…
View article: Childhood trauma is associated with reduced frontal gray matter volume: a large transdiagnostic structural MRI study
Childhood trauma is associated with reduced frontal gray matter volume: a large transdiagnostic structural MRI study Open
Background Childhood trauma increases risk for psychopathology and cognitive impairment. Prior research mainly focused on the hippocampus and amygdala in single diagnostic categories. However, other brain regions may be impacted by trauma …