Mariel Pinsky
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View article: Genetic Analysis of Candida albicans Filamentation by the Iron Chelator BPS Reveals a Role for a Conserved Kinase—WD40 Protein Pair
Genetic Analysis of Candida albicans Filamentation by the Iron Chelator BPS Reveals a Role for a Conserved Kinase—WD40 Protein Pair Open
Candida albicans is a major human pathogenic fungus that is distinguished by its capability to switch from a yeast to a hyphal morphology under different conditions. Here, we analyze the cellular effects of high concentrations of the iron …
View article: Ferric reductase-related proteins mediate fungal heme acquisition
Ferric reductase-related proteins mediate fungal heme acquisition Open
Heme can serve as iron source in many environments, including the iron-poor animal host environment. The fungal pathobiont Candida albicans expresses a family of extracellular CFEM hemophores that capture heme from host proteins and transf…
View article: Author response: Ferric reductase-related proteins mediate fungal heme acquisition
Author response: Ferric reductase-related proteins mediate fungal heme acquisition Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Heme can …
View article: Regulation of heme utilization and homeostasis in Candida albicans
Regulation of heme utilization and homeostasis in Candida albicans Open
Heme (iron-protoporphyrin IX) is an essential but potentially toxic cellular cofactor. While most organisms are heme prototrophs, many microorganisms can utilize environmental heme as iron source. The pathogenic yeast Candida albicans can …
View article: Regulation of heme utilization and homeostasis in <i>Candida albicans</i>
Regulation of heme utilization and homeostasis in <i>Candida albicans</i> Open
Heme (iron-protoporphyrin IX) is an essential but potentially toxic cellular cofactor. While most organisms are heme prototrophs, many microorganisms can utilize environmental heme as iron source. The pathogenic yeast Candida albicans can …
View article: Ferric reductase-related proteins mediate fungal heme acquisition
Ferric reductase-related proteins mediate fungal heme acquisition Open
Heme can serve as iron source in many environments, including the iron-poor animal host environment. The fungal pathobiont Candida albicans expresses a family of extracellular CFEM hemophores that capture heme from host proteins and transf…
View article: Using genetically encoded heme sensors to probe the mechanisms of heme uptake and homeostasis in <scp> <i>Candida albicans</i> </scp>
Using genetically encoded heme sensors to probe the mechanisms of heme uptake and homeostasis in <span> <i>Candida albicans</i> </span> Open
Candida albicans is a major fungal pathogen that can utilise hemin and haemoglobin as iron sources in the iron-scarce host environment. While C. albicans is a heme prototroph, we show here that it can also efficiently utilise external heme…
View article: Using genetically encoded heme sensors to probe the mechanisms of heme uptake and homeostasis in<i>Candida albicans</i>
Using genetically encoded heme sensors to probe the mechanisms of heme uptake and homeostasis in<i>Candida albicans</i> Open
Candida albicans is a major fungal pathogen that can utilize hemin and hemoglobin as iron sources in the iron-scarce host environment. While C. albicans is a heme prototroph, we show here that it can also efficiently utilize external heme …
View article: Human Serum Albumin Facilitates Heme-Iron Utilization by Fungi
Human Serum Albumin Facilitates Heme-Iron Utilization by Fungi Open
Heme constitutes a major iron source for microorganisms and particularly for pathogenic microbes; to overcome the iron scarcity in the animal host, many pathogenic bacteria and fungi have developed systems to extract and take up heme from …
View article: A Global Analysis of Kinase Function in Candida albicans Hyphal Morphogenesis Reveals a Role for the Endocytosis Regulator Akl1
A Global Analysis of Kinase Function in Candida albicans Hyphal Morphogenesis Reveals a Role for the Endocytosis Regulator Akl1 Open
The human pathogenic fungus Candida albicans can switch between yeast and hyphal morphologies as a function of environmental conditions and cellular physiology. The yeast-to-hyphae morphogenetic switch is activated by well-established, kin…
View article: Long-lived weight-reduced αMUPA mice show higher and longer maternal-dependent postnatal leptin surge
Long-lived weight-reduced αMUPA mice show higher and longer maternal-dependent postnatal leptin surge Open
We investigated whether long-lived weight-reduced αMUPA mice differ from their wild types in postnatal body composition and leptin level, and whether these differences are affected by maternal-borne factors. Newborn αMUPA and wild type mic…
View article: Regulation of the Candida albicans Hypha-Inducing Transcription Factor Ume6 by the CDK1 Cyclins Cln3 and Hgc1
Regulation of the Candida albicans Hypha-Inducing Transcription Factor Ume6 by the CDK1 Cyclins Cln3 and Hgc1 Open
The yeast to hypha (mold) morphogenetic switch of Candida albicans plays a role in its virulence and constitutes a diagnostic trait for this organism, the most prevalent systemic fungal pathogen in industrialized countries. It has long bee…
View article: Long-Lived αMUPA Mice Show Reduced Sexual Dimorphism in Lifespan, and in Energy and Circadian Homeostasis-Related Parameters
Long-Lived αMUPA Mice Show Reduced Sexual Dimorphism in Lifespan, and in Energy and Circadian Homeostasis-Related Parameters Open
Female αMUPA (alpha murine urokinase-like plasminogen activator) transgenic mice show increased lifespan, reduced body weight and food intake, and high-amplitude circadian rhythms with an endogenous period length (tau) of 24h, versus their…