Marielle Ernst
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View article: Mortality within three months after nonfatal ischemic stroke treated by mechanical thrombectomy in routine care—data from the German Stroke Registry
Mortality within three months after nonfatal ischemic stroke treated by mechanical thrombectomy in routine care—data from the German Stroke Registry Open
Background Mechanical thrombectomy (MT) is a highly effective treatment for large vessel occlusion (LVO) ischemic stroke. However, a substantial share of patients have lethal outcome within 3 months. Individualization of outcome prognostic…
View article: REcanalization of Distal Cerebral Vessels In Acute Stroke Using ApeRio (REVISAR)
REcanalization of Distal Cerebral Vessels In Acute Stroke Using ApeRio (REVISAR) Open
Background Although recently presented randomized trials have failed to prove an overall benefit of mechanical thrombectomy (MT) for patients with medium vessel occlusions (MeVOs), questions remain unanswered, particularly regarding the te…
View article: General Anesthesia Versus Conscious Sedation in Thrombectomy Patients With Low NIHSS Anterior Circulation Stroke
General Anesthesia Versus Conscious Sedation in Thrombectomy Patients With Low NIHSS Anterior Circulation Stroke Open
BACKGROUND: The optimal anesthetic approach for patients with acute ischemic stroke with large vessel occlusion but low National Institutes of Health Stroke Scale receiving mechanical thrombectomy remains unclear. We aimed to evaluate the …
View article: Susceptibility Vessel Sign and Intravenous Alteplase in Stroke Patients Treated with Thrombectomy
Susceptibility Vessel Sign and Intravenous Alteplase in Stroke Patients Treated with Thrombectomy Open
Background The susceptibility vessel sign (SVS) on baseline MRI in acute ischemic stroke patients has been associated with better outcomes post-thrombectomy. This study aimed to investigate whether the presence of the SVS modifies the trea…
View article: Time trends in mechanical thrombectomy (2017–2021): do real-world data reflect advances in evidence?
Time trends in mechanical thrombectomy (2017–2021): do real-world data reflect advances in evidence? Open
Background In recent years, we have witnessed a continuous, evidence-based expansion of indications for endovascular therapy (EVT) in the treatment of ischaemic stroke, driven by advancements in extended time windows and target vessel occl…
View article: Retrospective multicenter analysis of the Trenza Embolization Device for endovascular therapy of intracranial aneurysms: initial results and short-term follow-up
Retrospective multicenter analysis of the Trenza Embolization Device for endovascular therapy of intracranial aneurysms: initial results and short-term follow-up Open
Background Intrasaccular devices are increasingly used in endovascular therapy of intracranial aneurysms, in particular wide-necked and ruptured aneurysms. The Trenza Embolization Device (TED) is an innovative intrasaccular device for medi…
View article: Endovascular versus Best Medical Treatment for Acute Carotid Occlusion BelOw Circle of Willis (ACOBOW): The ACOBOW Study
Endovascular versus Best Medical Treatment for Acute Carotid Occlusion BelOw Circle of Willis (ACOBOW): The ACOBOW Study Open
For patients with symptomatic acute occlusions of the internal carotid artery below the circle of Willis, endovascular and best medical treatment were both effective and safe therapeutic options.
View article: Differentiation between multifocal CNS lymphoma and glioblastoma based on MRI criteria
Differentiation between multifocal CNS lymphoma and glioblastoma based on MRI criteria Open
Purpose Differentiating between glioblastoma (GB) with multiple foci (mGB) and multifocal central nervous system lymphoma (mCNSL) can be challenging because these cancers share several features at first appearance on magnetic resonance ima…
View article: Age and Functional Outcomes in Patients With Large Ischemic Stroke Receiving Endovascular Thrombectomy
Age and Functional Outcomes in Patients With Large Ischemic Stroke Receiving Endovascular Thrombectomy Open
Importance Randomized clinical trials have demonstrated the efficacy and safety of endovascular thrombectomy for acute ischemic stroke with large infarct. Patients older than 80 years with large infarct are commonly encountered in clinical…
View article: Endovascular Thrombectomy With and Without Preceding Thrombolysis in Posterior Circulation Stroke—Insights From STAR
Endovascular Thrombectomy With and Without Preceding Thrombolysis in Posterior Circulation Stroke—Insights From STAR Open
Background Multiple randomized trials could not establish the noninferiority of endovascular thrombectomy (EVT) alone without preceding intravenous thrombolysis (IVT) or superiority of IVT followed by EVT in anterior circulation large‐vess…
View article: Author Correction: Lysosomal and synaptic dysfunction markers in longitudinal cerebrospinal fluid of de novo Parkinson’s disease
Author Correction: Lysosomal and synaptic dysfunction markers in longitudinal cerebrospinal fluid of de novo Parkinson’s disease Open
View article: Plasma proteomics identify biomarkers predicting Parkinson’s disease up to 7 years before symptom onset
Plasma proteomics identify biomarkers predicting Parkinson’s disease up to 7 years before symptom onset Open
Parkinson’s disease is increasingly prevalent. It progresses from the pre-motor stage (characterised by non-motor symptoms like REM sleep behaviour disorder), to the disabling motor stage. We need objective biomarkers for early/pre-motor d…
View article: The effect of inadvertent systemic hypothermia after mechanical thrombectomy in patients with large-vessel occlusion stroke
The effect of inadvertent systemic hypothermia after mechanical thrombectomy in patients with large-vessel occlusion stroke Open
Background and aims Postinterventional hypothermia is a frequent complication in patients with large-vessel occlusion strokes (LVOS) after mechanical thrombectomy (MT). This inadvertent hypothermia might potentially have neuroprotective bu…
View article: Lysosomal and synaptic dysfunction markers in longitudinal cerebrospinal fluid of de novo Parkinson’s disease
Lysosomal and synaptic dysfunction markers in longitudinal cerebrospinal fluid of de novo Parkinson’s disease Open
View article: Endovascular thrombectomy with and without preceding thrombolysis in posterior circulation stroke – insights from STAR
Endovascular thrombectomy with and without preceding thrombolysis in posterior circulation stroke – insights from STAR Open
Background Multiple randomized trials could not establish the non-inferiority of endovascular thrombectomy (EVT) alone without preceding intravenous thrombolysis (IVT) or superiority of IVT followed by EVT in anterior circulation large ves…
View article: Differentiation of multiple brain metastases and glioblastoma with multiple foci using MRI criteria
Differentiation of multiple brain metastases and glioblastoma with multiple foci using MRI criteria Open
View article: Multicenter study of the safety and effectiveness of intracranial aneurysm treatment with the p64MW-HPC flow modulation device
Multicenter study of the safety and effectiveness of intracranial aneurysm treatment with the p64MW-HPC flow modulation device Open
Background and purpose The new p64 flow diverter with hydrophilic polymer coating (HPC) was designed to reduce thrombogenicity. To date, it is unclear how antithrombogenic surface modifications affect neoendothelialization and thrombus for…
View article: MRI vs CT for Baseline Imaging Evaluation in Acute Large Artery Ischemic Stroke
MRI vs CT for Baseline Imaging Evaluation in Acute Large Artery Ischemic Stroke Open
ClinicalTrials.gov Identifier: NCT03192332.
View article: Lysosomal and synaptic dysfunction markers in longitudinal cerebrospinal fluid spanning from healthy subjects to prodromal and manifest Parkinson’s disease
Lysosomal and synaptic dysfunction markers in longitudinal cerebrospinal fluid spanning from healthy subjects to prodromal and manifest Parkinson’s disease Open
Lysosomal and synaptic dysfunctions are hallmarks in multiple neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease (PD) and could be relevant from a biomarker perspective. Biomarker data on prodromal and early P…
View article: Predictors of functional outcome after thrombectomy for M2 occlusions: a large scale experience from clinical practice
Predictors of functional outcome after thrombectomy for M2 occlusions: a large scale experience from clinical practice Open
Mechanical thrombectomy (MT) for acute ischemic stroke with medium vessel occlusions is still a matter of debate. We sought to identify factors associated with clinical outcome after MT for M2-occlusions based on data from the German Strok…
View article: Association Between Recanalization Attempts and Functional Outcome After Thrombectomy for Large Ischemic Stroke
Association Between Recanalization Attempts and Functional Outcome After Thrombectomy for Large Ischemic Stroke Open
BACKGROUND: Recently, 3 randomized controlled trials provided high-level evidence that patients with large ischemic stroke achieved better functional outcomes after endovascular therapy than with medical care alone. We aimed to investigate…
View article: Thrombectomy for M2 Occlusions: Predictors of Successful and Futile Recanalization
Thrombectomy for M2 Occlusions: Predictors of Successful and Futile Recanalization Open
BACKGROUND: Patient-specific factors associated with successful recanalization in mechanical thrombectomy (MT) have been evaluated for acute ischemic stroke with large vessel occlusion. However, MT for M2 occlusions is still a matter of de…
View article: Effect of anesthetic strategies on distal stroke thrombectomy in the anterior and posterior cerebral artery
Effect of anesthetic strategies on distal stroke thrombectomy in the anterior and posterior cerebral artery Open
Background Numerous questions regarding procedural details of distal stroke thrombectomy remain unanswered. This study assesses the effect of anesthetic strategies on procedural, clinical and safety outcomes following thrombectomy for dist…
View article: Association Between Intravenous Thrombolysis and Clinical Outcomes Among Patients With Ischemic Stroke and Unsuccessful Mechanical Reperfusion
Association Between Intravenous Thrombolysis and Clinical Outcomes Among Patients With Ischemic Stroke and Unsuccessful Mechanical Reperfusion Open
Importance Clinical evidence of the potential treatment benefit of intravenous thrombolysis preceding unsuccessful mechanical thrombectomy (MT) is scarce. Objective To determine whether intravenous thrombolysis (IVT) prior to unsuccessful …
View article: Optimizing the structure of interdisciplinary tumor boards for effective cancer care
Optimizing the structure of interdisciplinary tumor boards for effective cancer care Open
Introduction Multi-professional interdisciplinary tumor boards (ITB) are essential institutions to discuss all newly diagnosed, relapsed or complex cancer patients in a team of specialists to find an optimal cancer care plan for each indiv…
View article: Proteomics and machine learning identify a distinct biomarker panel to detect prodromal and early Parkinson’s disease
Proteomics and machine learning identify a distinct biomarker panel to detect prodromal and early Parkinson’s disease Open
Parkinson’s disease (PD) is an increasingly prevalent neurodegenerative disease for which readily available and non-invasive diagnostic biomarkers are scarce. Here, we present a panel of proteomic plasma biomarkers, capable of discriminati…
View article: Brainstem atrophy in dementia with Lewy bodies compared with progressive supranuclear palsy and Parkinson’s disease on MRI
Brainstem atrophy in dementia with Lewy bodies compared with progressive supranuclear palsy and Parkinson’s disease on MRI Open
Background Although Dementia with Lewy bodies (DLB) is the second most common form of dementia in elderly patients, it remains underdiagnosed compared with Alzheimer's (AD) and Parkinson's diseases (PD). This may be explained by overlappin…
View article: Abstract Number ‐ 240: Association of intravenous thrombolysis and pre‐interventional reperfusion: a post‐hoc analysis of the SWIFT DIRECT trial
Abstract Number ‐ 240: Association of intravenous thrombolysis and pre‐interventional reperfusion: a post‐hoc analysis of the SWIFT DIRECT trial Open
Introduction One potential benefit of intravenous thrombolysis (IVT) before mechanical thrombectomy (MT) is pre‐interventional reperfusion. Currently, there is a paucity of data regarding the occurrence of pre‐interventional reperfusion in…
View article: Patterns of acute ischemic stroke and intracranial hemorrhage in patients with COVID-19
Patterns of acute ischemic stroke and intracranial hemorrhage in patients with COVID-19 Open
View article: Comparison of EPI DWI and STEAM DWI in Early Postoperative MRI Controls After Resection of Tumors of the Central Nervous System
Comparison of EPI DWI and STEAM DWI in Early Postoperative MRI Controls After Resection of Tumors of the Central Nervous System Open