Explanipedia

Paediatric Emergency Department Mental Health and Behavioural Presentations in Australia Before and After the Onset of the COVID‐19 Pandemic: Retrospective Observational Study Open

Jackson Newberry‐Dupé, Glenn Melvin, Kylie King, Michael J. White, Vicki Anderson , et al. · 2025

Objectives Although child and adolescent mental health and behavioural presentations to hospital emergency departments (EDs) increased during the first 2 years of the COVID‐19 pandemic (2020 and 2021), little is known about the characteris…

Bootstrapping a Conversational Guide for Colonoscopy Prep Open

Pulkit Arya, Madeleine Bloomquist, Subhankar Chakraborty, Andrew Perrault, William Schuler , et al. · 2023

Pulkit Arya, Madeleine Bloomquist, Subhankar Chakraborty, Andrew Perrault, William Schuler, Eric Fosler-Lussier, Michael White. Proceedings of the 24th Meeting of the Special Interest Group on Discourse and Dialogue. 2023.

Accelerating Towards P. vivax Elimination with a Novel Serological Test-and-Treat Strategy: A Modelling Case Study in Brazil Open

Narimane Nekkab, Thomas Obadia, Wuelton Marcelo Monteiro, Marcus Lacerda, Michael J. White , et al. · 2023

Interrupting Pedestrians in Indonesia; Effect of Climate on Perceived Steepness and Stair Climbing Behaviour Open

Febriani Fajar Ekawati, Michael J. White, Frank F. Eves · 2022

Increased activity during daily life is one public health initiative to reduce population inactivity. Increasing temperature and humidity influence walking for transport by reducing the blood supply available to exercising muscles. This st…

988 B-cell receptor (BCR) repertoire and antibody recognition analysis of melanoma patients treated with neoadjuvant immune checkpoint blockade (ICB) Open

Monika A. Zelazowska, Somnath Paul, Joshua B. Plummer, Manoj Chelvanambi, Beth A. Helmink , et al. · 2022

Background Enriched B cell signature is correlated with positive outcome of immune checkpoint blockade (ICB) therapy in melanoma¹ and other cancers.² B cells have the capability to engage and activate other immune eff…

Chronic (-)-epicatechin administration does not affect contracting skeletal muscle microvascular oxygenation Open

Clark T. Holdsworth, Steven W. Copp, Tadakatsu Inagaki, Daniel M. Hirai, Scott Ferguson , et al. · 2022

The flavanol -(-)epicatechin (EPI) is a naturally occurring component of cocoa, consumption of which is associated with numerous cardiovascular health benefits.Chronic EPI reportedly augments mouse skeletal muscle capillarity and mitochond…

Aging Regulates Post-Viral Asthmatic Airway Pathology Open

Guy Hazan, Anna Eubanks, Carrie Gierasch, Jeffrey Atkinson, Carolyn Fox , et al. · 2021

Asthma is a common chronic disease of childhood, but for unknown reasons disease activity sometimes subsides as children mature. To understand why, we exposed mice across a range of ages to viral and allergic triggers of asthma exacerbatio…

Home-Based Stair Climbing as an Intervention for Disease Risk in Adult Females; A Controlled Study Open

Elpida Michael, Michael J. White, Frank F. Eves · 2021

Cardiovascular disease and the metabolic syndrome are major contributors to health care expenditure. Increased physical activity reduces disease risk. The study compared effects of walking up and down stairs at home with continuous, gym-ba…

Conservative management of stage IIB ovarian carcinoma with favorable oncology and fertility outcomes Open

Ashley Bartalot, Michael J. White, Tanja Pejovict, Drew V. Tortoriello, Farr Nezhat · 2021

•Fertility treatment prior to definitive cancer therapy in stage IIB EOC.•Both fertility and oncologic outcomes were successful.•The role of Multidisciplinary team is critical.

Hide and seek anyone? Exchange of Views rebuttal: reply to Haouzi Open

Michael J. White, Richard Bruce · 2020

We have enjoyed Dr Hauozi's Exchange of Views (Hauozi, 2020) on the topic of thin fibre muscle afferent involvement in the control of breathing in human exercise. The take home message from his article appears to be that this is a difficul…

The role of muscle mechano and metaboreflexes in the control of ventilation: breathless with (over) excitement? Open

Michael J. White, Richard Bruce · 2020

Mechanically and metabolically sensitive thin fibre (group III and IV) muscle afferents are activated during exercise, causing reflex cardiovascular responses that are essential to normal cardiovascular control. Impaired exercise performan…

Altered Baroreflex-Mediated Cardiovascular Responses to Acute Hypotension in Heart Failure Patients Compared to Healthy Adults Open

Rachel C. Drew, Chelsea N. Lindblad, Soraya Samii, Cheryl Blaha, Michael J. White , et al. · 2020

Patients with heart failure (HF) exhibit baroreflex dysfunction, which is associated with increased morbidity and mortality. Orthostatic hypotension, a decrease in blood pressure (BP) upon standing, is a condition that often occurs in HF, …

In response to the recent letter by Antonio Crisafulli Open

Richard Bruce, Michael J. White · 2020

We would like to thank the author of a recent letter for their supportive words about our publication in Experimental Physiology (Lam, Greenhough, Nazari, White, & Bruce, 2019). We agree that some of the findings we made bearcomparison wit…

Control of exercise hyperpnoea: Contributions from thin‐fibre skeletal muscle afferents Open

Richard Bruce, Caroline J. Jolley, Michael J. White · 2019

New Findings What is the topic of this review? In this review, we examine the evidence for control mechanisms underlying exercise hyperpnoea, giving attention to the feedback from thin‐fibre skeletal muscle afferents, and highlight the fre…

Project Azorian: The CIA and the Raising of the K-129 Open

Norman Polmar, Michael J. White · 2019

Impact of sleep opportunity on asthma outcomes in adolescents Open

Lisa J. Meltzer, Dean W. Beebe, Stephanie Jump, Kassie D. Flewelling, D. Sundström , et al. · 2019

Muscle metaboreflex activation increases ventilation and heart rate during dynamic exercise in humans Open

Elliot P. Lam, Evelyn Greenhough, Parsa Nazari, Michael J. White, Richard Bruce · 2019

New Findings What is the central question of this study? Classically, the stimulation of thin‐fibre skeletal muscle afferents, via the application of postexercise circulatory occlusion (PECO) at rest, fails to generate ventilatory response…

0810 Sleep and Ferritin in Adolescent Females With and Without Asthma Open

Lisa J. Meltzer, Kassie D. Flewelling, Stephanie Jump, D. Sundström, Michael J. White · 2019

Although children with asthma are known to have sleep disturbances, few studies have compared sleep quality between adolescents with and without asthma using both validated objective and subjective measures. Further, recent studies have su…

Sensitivity of the human ventilatory response to muscle metaboreflex activation during concurrent mild hypercapnia Open

Jassim Mohammed Alghaith, George M. Balanos, Francis Eves, Michael J. White · 2018

New Findings What is the central question of this study? What is the relationship between the level of systemic hypercapnia and the magnitude of the additional hyperpnoea produced in response to a standardized level of muscle metaboreflex …

0851 Sleep Duration and Asthma Outcomes in Adolescents Open

Lisa J. Meltzer, Stephanie Jump, Kassie D. Flewelling, D. Sundström, Michael J. White , et al. · 2018

Asthma is the most common pediatric chronic illness, impacting approximately 10% of adolescents. There is a need to examine modifiable behaviors, such as sleep duration, which may reduce the morbidity of asthma (e.g., missed school days). …

Does the duration of time between dilatation and curettage and single euploid frozen embryo transfer affect clinical outcome? Open

Michael J. White, L. Sekhon, Joseph A. Lee, Margaret Daneyko, Dmitry Gounko , et al. · 2018

0915 SELF-REPORTED SLEEP BEHAVIORS AND SLEEP DISTURBANCES IN ADOLESCENTS WITH AND WITHOUT ASTHMA Open

AT Meyer, Stephanie Jump, J Ruybal, D. Sundström, Michael J. White , et al. · 2017

Asthma impacts approximately 10% of adolescents. Youth with asthma are at risk for increased sleep disturbance, even when their asthma is well-controlled. However, only a small number of studies have examined sleep behaviors in addition to…

Ventilatory responses to muscle metaboreflex activation in chronic obstructive pulmonary disease Open

Richard Bruce, Alice Turner, Michael J. White · 2016

Key points Recent evidence indicates a role for group III/IV muscle afferents in reflex control of the human ventilatory response to exercise. Dyspnoea in chronic obstructive pulmonary disease (COPD) may be linked to this reflex response. …

The ventilatory response to muscle afferent activation during concurrent hypercapnia in humans: central and peripheral mechanisms Open

Richard Bruce, Michael J. White · 2015

New Findings What is the central question of this study? During hypercapnia but not normocapnia, activation of muscle afferents by postexercise circulatory occlusion increases ventilation, possibly due to additional activation of metabolit…

Rebuttal from John H. Coote and Michael J. White Open

John H. Coote, Michael J. White · 2015

The study by D'Souza et al. (2015) provides evidence that endurance exercise training results in down-regulation of the pacemaker channel protein HCN4, with a consequent decrease in the funny current, so lengthening hyperpolarization betwe…

CrossTalk proposal: Bradycardia in the trained athlete is attributable to high vagal tone Open

John H. Coote, Michael J. White · 2015

Endurance trained athletes are well known to have low resting heart rates, with values below 30 beats min−1 reported. Such low resting heart rates result from long periods of endurance training (Carter et al. 2003). We argue here that an i…

Ellen G. White's Counsel to Leaders in Conflict Open

Michael J. White · 2015

How should we relate to people in the church who adamantly disagree with us personally or with a commonly accepted position? How do we support what is admirable about controversial leaders while still disagreeing with the way they express …

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