Marija Grdić Rajković
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View article: Comparative Evaluation of Four Hematology Analyzers: Siemens Advia 2120i, Sysmex <scp>XN</scp> ‐1000, Mindray <scp>BC</scp> ‐5310 <scp>CRP</scp> , and Beckman Coulter <scp>DxH</scp> 900. Do Similar Performances Equal Same Quality?
Comparative Evaluation of Four Hematology Analyzers: Siemens Advia 2120i, Sysmex <span>XN</span> ‐1000, Mindray <span>BC</span> ‐5310 <span>CRP</span> , and Beckman Coulter <span>DxH</span> 900. Do Similar Performances Equal Same Quality? Open
Introduction This study provides a comprehensive verification and comparative evaluation of four hematology analyzers (HA) with a five‐part differential blood count (5‐DIFF) (Siemens Advia 2120i, Sysmex XN‐1000, Mindray BC‐5310CRP, Beckman…
View article: TPMT and HLA-DQ Allelic Variants in Relation to Drug Response, Safety and Need for Therapy Optimization in Pediatric Inflammatory Bowel Disease
TPMT and HLA-DQ Allelic Variants in Relation to Drug Response, Safety and Need for Therapy Optimization in Pediatric Inflammatory Bowel Disease Open
Background/Objectives: Pharmacogenetics examines genome variability and its influence on drug efficacy and toxicity, forming the foundation for personalized medicine. Patients with inflammatory bowel disease (IBD) treated with azathioprine…
View article: Je li kvantitativno mjerenje nezrelih granulocita na hematološkomanalizatoru sysmex xn-1000 doista pouzdano?
Je li kvantitativno mjerenje nezrelih granulocita na hematološkomanalizatoru sysmex xn-1000 doista pouzdano? Open
Introduction: The diagnostic and prognostic significance of immature neutrophils has been extensively documented. To ensure rapid response to our clinicians we aimed to verify the reliability of the quantitative measurement of immature gra…
View article: How to handle lipemic CBC samples on Sysmex hematology analyzers?
How to handle lipemic CBC samples on Sysmex hematology analyzers? Open
Objectives Lipemia poses a significant preanalytical problem for complete blood count (CBC) measurement due to limited and non-standardized methods for recognition and removal. We aimed to verify the optical hemoglobin (Hb-O) measurements …
View article: Complete blood count parameters and inflammation-related biomarkers in patients with colorectal carcinoma
Complete blood count parameters and inflammation-related biomarkers in patients with colorectal carcinoma Open
The aim of this study was to determine whether there are differences in complete blood count parameters (CBC) and inflammation-related biomarkers, MPV/PC, PLR, NLR, LWR, LMR, NMR, and LCR, among patients with colorectal carcinoma (CRC) and…
View article: MicroRNA-193a-3p as a Valuable Biomarker for Discriminating between Colorectal Cancer and Colorectal Adenoma Patients
MicroRNA-193a-3p as a Valuable Biomarker for Discriminating between Colorectal Cancer and Colorectal Adenoma Patients Open
Specific markers for colorectal cancer (CRC), preceded by colorectal adenoma (pre-CRC), are lacking. This study aimed to investigate whether microRNAs (miR-19a-3p, miR-92a-3p, miR-193a-3p, and miR-210-3p) from tissues and exosomes are pote…
View article: Paraoxonase and arylesterase activity of paraoxonase 1 and oxidative stress parameters in cervical intraepithelial neoplasia
Paraoxonase and arylesterase activity of paraoxonase 1 and oxidative stress parameters in cervical intraepithelial neoplasia Open
IntroductionParaoxonase 1 (PON1) is the enzyme that removes carcinogenic radicals from lipids. The aim of the study was to investigate the differences in PON1 activity and oxidation stress parameters between patients with cervical intraepi…
View article: Circulating Tumor Cells in Colorectal Cancer: Detection Systems and Clinical Utility
Circulating Tumor Cells in Colorectal Cancer: Detection Systems and Clinical Utility Open
Colorectal cancer (CRC) is the third most common cancer worldwide. The high mortality from CRC is mainly related to metastasis affecting distant organs and their function. Dissemination of tumor cells from the primary tumor and hematogeneo…
View article: Increased HSP70 and TLR2 Gene Expression and Association of HSP70 rs6457452 Single Nucleotide Polymorphism with the Risk of Chronic Obstructive Pulmonary Disease in the Croatian Population
Increased HSP70 and TLR2 Gene Expression and Association of HSP70 rs6457452 Single Nucleotide Polymorphism with the Risk of Chronic Obstructive Pulmonary Disease in the Croatian Population Open
Heat shock protein 70 (Hsp70) engages Toll-like receptors (TLR) 2 and 4 when found in the extracellular compartment and contributes to inflammation in chronic obstructive pulmonary disease (COPD). Since there is growing evidence for the ge…
View article: Profiling Colorectal Cancer in the Landscape Personalized Testing—Advantages of Liquid Biopsy
Profiling Colorectal Cancer in the Landscape Personalized Testing—Advantages of Liquid Biopsy Open
Drug-specific therapeutic approaches for colorectal cancer (CRC) have contributed to significant improvements in patient health. Nevertheless, there is still a great need to improve the personalization of treatments based on genetic and ep…
View article: Association of Plasma Heat Shock Protein 70 with Disease Severity, Smoking and Lung Function of Patients with Chronic Obstructive Pulmonary Disease
Association of Plasma Heat Shock Protein 70 with Disease Severity, Smoking and Lung Function of Patients with Chronic Obstructive Pulmonary Disease Open
Extracellular heat shock protein 70 (eHsp70) might modulate immune responses in chronic obstructive pulmonary disease (COPD). The aim of the study was to explore eHsp70 concentration in stable COPD, its association with disease severity an…
View article: Association of Plasma Heat Shock Protein 70 with Disease Severity, Smoking and Lung Function of Patients with Chronic Obstructive Pulmonary Disease
Association of Plasma Heat Shock Protein 70 with Disease Severity, Smoking and Lung Function of Patients with Chronic Obstructive Pulmonary Disease Open
Background: Extracellular heat shock protein 70 (eHsp70) acts like a damage-associated molecular pattern (DAMP) and it might modulate immune responses in patients with chronic obstructive pulmonary disease (COPD). The aim of the study was …
View article: Extracellular adenosine triphosphate is associated with airflow limitation severity and symptoms burden in patients with chronic obstructive pulmonary disease
Extracellular adenosine triphosphate is associated with airflow limitation severity and symptoms burden in patients with chronic obstructive pulmonary disease Open
Extracellular adenosine triphosphate (eATP)-driven inflammation was observed in chronic obstructive pulmonary disease (COPD) but was not investigated in patients’ blood. Therefore, this study aimed to investigate eATP concentration in plas…
View article: Extracellular Hsp70 modulates the inflammatory response of cigarette smoke extract in NCI‐H292 cells
Extracellular Hsp70 modulates the inflammatory response of cigarette smoke extract in NCI‐H292 cells Open
New Findings What is the central question of this study? Does extracellular heat shock protein 70 (eHsp70) alter cigarette smoke extract (CSE)‐induced inflammatory responses in NCI‐H292 bronchial epithelial cells? What is the main finding …