Marika Elsa Friano
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View article: C-terminal binding protein 2 interacts with JUNB to control macrophage inflammation
C-terminal binding protein 2 interacts with JUNB to control macrophage inflammation Open
Although acute inflammatory responses are critical for survival, chronic inflammation is a leading cause of disease and mortality worldwide. Nevertheless, our mechanistic understanding of pathogenesis is still limited and precise treatment…
View article: Lipid sensing nuclear receptors involved in the pathogenesis of fatty liver disease
Lipid sensing nuclear receptors involved in the pathogenesis of fatty liver disease Open
Non‐alcoholic fatty liver disease (NAFLD) begins with lipid accumulation and progresses toward inflammation and fibrosis. Nuclear receptors (NRs), like the Peroxisome Proliferator‐Activated Receptors alpha and gamma (PPARα and PPARy), the …
View article: <strong>β-cell specific</strong> <em><strong>E2f1 </strong></em><strong>deficiency impairs glucose homeostasis, β-cell</strong> <strong>identity and insulin secretion</strong>
<strong>β-cell specific</strong> <em><strong>E2f1 </strong></em><strong>deficiency impairs glucose homeostasis, β-cell</strong> <strong>identity and insulin secretion</strong> Open
The loss of pancreatic β-cell identity emerges as an important feature of type 2 diabetes development, but the molecular mechanisms are still elusive. Here, we explore the cell-autonomous role of the cell cycle regulator and transcription …
View article: β-Cell–Specific <i>E2f1</i> Deficiency Impairs Glucose Homeostasis, β-Cell Identity, and Insulin Secretion
β-Cell–Specific <i>E2f1</i> Deficiency Impairs Glucose Homeostasis, β-Cell Identity, and Insulin Secretion Open
The loss of pancreatic β-cell identity has emerged as an important feature of type 2 diabetes development, but the molecular mechanisms are still elusive. Here, we explore the cell-autonomous role of the cell-cycle regulator and transcript…
View article: <strong>β-cell specific</strong> <em><strong>E2f1 </strong></em><strong>deficiency impairs glucose homeostasis, β-cell</strong> <strong>identity and insulin secretion</strong>
<strong>β-cell specific</strong> <em><strong>E2f1 </strong></em><strong>deficiency impairs glucose homeostasis, β-cell</strong> <strong>identity and insulin secretion</strong> Open
The loss of pancreatic β-cell identity emerges as an important feature of type 2 diabetes development, but the molecular mechanisms are still elusive. Here, we explore the cell-autonomous role of the cell cycle regulator and transcription …
View article: EJE Prize 2023: genes on steroids—genomic control of hepatic metabolism by the glucocorticoid receptor
EJE Prize 2023: genes on steroids—genomic control of hepatic metabolism by the glucocorticoid receptor Open
Glucocorticoids are essential hormones produced by the adrenal cortex with prominent circadian rhythmicity and in times of stress. Glucocorticoids maintain liver homeostasis through coordinated activities that control the major pathways of…
View article: Conversion of Gastrointestinal Somatostatin-Expressing D Cells Into Insulin-Producing Beta-Like Cells Upon Pax4 Misexpression
Conversion of Gastrointestinal Somatostatin-Expressing D Cells Into Insulin-Producing Beta-Like Cells Upon Pax4 Misexpression Open
Type 1 diabetes results from the autoimmune-mediated loss of insulin-producing beta-cells. Accordingly, important research efforts aim at regenerating these lost beta-cells by converting pre-existing endogenous cells. Following up on previ…
View article: Gfi1 Loss Protects against Two Models of Induced Diabetes
Gfi1 Loss Protects against Two Models of Induced Diabetes Open
Background: Although several approaches have revealed much about individual factors that regulate pancreatic development, we have yet to fully understand their complicated interplay during pancreas morphogenesis. Gfi1 is transcription fact…
View article: Epigenetic Control of Pancreatic Regeneration in Diabetes
Epigenetic Control of Pancreatic Regeneration in Diabetes Open
Both type 1 and type 2 diabetes are conditions that are associated with the loss of insulin-producing β-cells within the pancreas. An active research therefore aims at regenerating these β-cells with the hope that they could restore euglyc…
View article: Role of ghrelin in pancreatic development and function
Role of ghrelin in pancreatic development and function Open
Ghrelin is a gastric peptide with anabolic functions. It acutely stimulates growth hormone (GH) secretion from the anterior pituitary glands and modulates hypothalamic circuits that control food intake and energy expenditure. Besides its c…