Marina H. de Jager
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View article: Pre-Existing Allergic Inflammation Alters Both Innate and Adaptive Immune Responses in Mice Co-Infected with Influenza Virus
Pre-Existing Allergic Inflammation Alters Both Innate and Adaptive Immune Responses in Mice Co-Infected with Influenza Virus Open
Asthma, a chronic airway disease, is marked by allergic inflammation, hyperresponsiveness, and tissue remodeling. Influenza infections in asthma patients can cause severe exacerbations, though the underlying mechanisms remain unclear. This…
View article: TRAPping the effects of tobacco smoking: the regulation and function of <i>Acp5</i> expression in lung macrophages
TRAPping the effects of tobacco smoking: the regulation and function of <i>Acp5</i> expression in lung macrophages Open
This study has uncovered that the enzyme tartrate-resistant acid phosphatase (TRAP) is crucial for alveolar macrophage proliferation through a β-catenin-dependent pathway. Importantly, TRAP influences this important ability of alveolar mac…
View article: Cigarette smoking prolongs inflammation associated with influenza infection and delays its clearance in mice
Cigarette smoking prolongs inflammation associated with influenza infection and delays its clearance in mice Open
In this study, we describe how cigarette smoke exposure modulates immune responses against influenza in mice over time. Using a unique model that continues smoke exposure after infection, we demonstrate that inflammation is prolonged and v…
View article: Osteoprotegerin is an Early Marker of the Fibrotic Process and of Antifibrotic Treatment Responses in Ex Vivo Lung Fibrosis
Osteoprotegerin is an Early Marker of the Fibrotic Process and of Antifibrotic Treatment Responses in Ex Vivo Lung Fibrosis Open
View article: Osteoprotegerin is an early marker of the fibrotic process and of antifibrotic treatment responses in ex vivo lung fibrosis
Osteoprotegerin is an early marker of the fibrotic process and of antifibrotic treatment responses in ex vivo lung fibrosis Open
Background Lung fibrosis is a chronic lung disease with a high mortality rate with only two approved drugs (pirfenidone and nintedanib) to attenuate its progression. To date there are no reliable biomarkers to assess fibrosis development a…
View article: Pre-Existing Allergic Inflammation Alters Both Innate and Adaptive Immune Responses in Mice Co-Infected with Influenza Virus
Pre-Existing Allergic Inflammation Alters Both Innate and Adaptive Immune Responses in Mice Co-Infected with Influenza Virus Open
View article: Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation
Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation Open
Rationale: Microplastics are a pressing global concern, and inhalation of microplastic fibers has been associated with interstitial and bronchial inflammation in flock workers. However, how microplastic fibers affect the lungs is un…
View article: Regional Differences in Human Intestinal Drug Metabolism
Regional Differences in Human Intestinal Drug Metabolism Open
View article: Human and rat precision-cut intestinal slices as ex vivo models to study bile acid uptake by the apical sodium-dependent bile acid transporter
Human and rat precision-cut intestinal slices as ex vivo models to study bile acid uptake by the apical sodium-dependent bile acid transporter Open
View article: Anticancer Gold <i>N</i>‐Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study
Anticancer Gold <i>N</i>‐Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study Open
A series of organometallic Au I N ‐heterocyclic carbene (NHC) complexes was synthesized and characterized for anticancer activity in four human cancer cell lines. The compounds’ toxicity in healthy tissue was determined using precision‐cut…
View article: The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo
The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo Open
View article: P‐gp activity and inhibition in the different regions of human intestine <i>ex vivo</i>
P‐gp activity and inhibition in the different regions of human intestine <i>ex vivo</i> Open
Although intestinal P‐glycoprotein (P‐gp) has been extensively studied in vitro and in animals, its activity and the consequences of P‐gp inhibition for drug disposition and toxicity in humans are still difficult to accurately extrapolate …
View article: Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo
Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo Open