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View article: Dorso lateral prefrontal cortex stimulation with TMS in chronic migraine individuals refractory to anti-CGRP monoclonal antibodies: Clinical, neuropsychological and neurophysiological effects
Dorso lateral prefrontal cortex stimulation with TMS in chronic migraine individuals refractory to anti-CGRP monoclonal antibodies: Clinical, neuropsychological and neurophysiological effects Open
Background People with high-frequency episodic migraine or chronic migraine may have resistant or refractory forms. The lack of efficacy of pharmacologic therapies is a major clinical challenge that requires alternative strategies, includi…
View article: Temporal interaction information and laser evoked responses: preliminary results in fibromyalgia patients with small fibers pathology
Temporal interaction information and laser evoked responses: preliminary results in fibromyalgia patients with small fibers pathology Open
Objectives We propose a novel application of higher-order information-theoretic measures to assess the temporal interaction information (TII) between laser-evoked potentials (LEPs) and individual pain ratings in healthy subjects and patien…
View article: Sensory neuron–expressed FGF13 controls nociceptive signaling in diabetic neuropathy models
Sensory neuron–expressed FGF13 controls nociceptive signaling in diabetic neuropathy models Open
Nociception involves complex signaling, yet intrinsic mechanisms bidirectionally regulating this process remain unexplored. Here, we show that the fibroblast growth factor 13 (FGF13)/Nav1.7 protein-protein interaction (PPI) complex bidirec…
View article: Efficacy of monoclonal antibodies against CGRP in migraine patients with fibromyalgia comorbidity: a retrospective monocentric observational study
Efficacy of monoclonal antibodies against CGRP in migraine patients with fibromyalgia comorbidity: a retrospective monocentric observational study Open
View article: Combined Proxies for Heart Rate Variability as a Global Tool to Assess and Monitor Autonomic Dysregulation in Fibromyalgia and Disease-Related Impairments
Combined Proxies for Heart Rate Variability as a Global Tool to Assess and Monitor Autonomic Dysregulation in Fibromyalgia and Disease-Related Impairments Open
Background: Heart rate variability (HRV) provides both linear and nonlinear autonomic proxies that can be informative of health status in fibromyalgia (FM), where sympatho-vagal abnormalities are common. This retrospective observational st…
View article: Evidence-based guidelines for the pharmacological treatment of migraine
Evidence-based guidelines for the pharmacological treatment of migraine Open
We here present evidence-based guidelines for the pharmacological treatment of migraine. These guidelines, created by the Italian Society for the Study of Headache and the International Headache Society, aim to offer clear, actionable reco…
View article: Evidence-based guidelines for the pharmacological treatment of migraine, summary version
Evidence-based guidelines for the pharmacological treatment of migraine, summary version Open
We here present evidence-based guidelines for the pharmacological treatment of migraine. These guidelines, created by the Italian Society for the Study of Headache and the International Headache Society, aim to offer clear, actionable reco…
View article: Therapeutic approach to fibromyalgia: a consensus statement on pharmacological and non-pharmacological treatment from the neuropathic pain special interest group of the Italian neurological society
Therapeutic approach to fibromyalgia: a consensus statement on pharmacological and non-pharmacological treatment from the neuropathic pain special interest group of the Italian neurological society Open
Background Although fibromyalgia is a disabling disease, there is no targeted therapy for specific neurotransmitters or inflammatory mediators. Our aim was to provide neurologists with practical guidance for the management of these difficu…
View article: Abnormal cortical neural synchronization mechanisms in quiet wakefulness in patients with Symptomatic Huntington and Dementia due to Alzheimer’s disease
Abnormal cortical neural synchronization mechanisms in quiet wakefulness in patients with Symptomatic Huntington and Dementia due to Alzheimer’s disease Open
Background Huntington’s disease (HD) is a progressive neurodegenerative disorder phenotypically manifested by motor, cognitive and psychiatric symptoms (Novak and Tabrizi, 2011). These patients are also characterized by vigilance abnormali…
View article: Abnormalities of Cortical Neural Synchronization Mechanisms in Patients With Dementia Due to Parkinson’s and Sintomatic Huntington’s Diseases
Abnormalities of Cortical Neural Synchronization Mechanisms in Patients With Dementia Due to Parkinson’s and Sintomatic Huntington’s Diseases Open
Background Parkinson’s disease and Huntington’s disease are both neurodegenerative conditions involving the basal ganglia area of the brain. Both conditions can cause symptoms that affect movement. Cognitive decline or dementia can also oc…
View article: Plasma neurofilament light chain in fibromyalgia: A case control study exploring correlation with clinical and cognitive features
Plasma neurofilament light chain in fibromyalgia: A case control study exploring correlation with clinical and cognitive features Open
Background Plasma neurofilament light chain (NFL) has been measured as a biomarker of neuronal damage in various neurological disorders. Elevated tau and β‐amyloid levels have been found in patients with fibromyalgia (FM). The aim of the p…
View article: Effect of Aesthetic Images on a Population with Mild Cognitive Decline: An Electroencephalography/Functional Near-Infrared Spectroscopy Study
Effect of Aesthetic Images on a Population with Mild Cognitive Decline: An Electroencephalography/Functional Near-Infrared Spectroscopy Study Open
Neuroaesthetics is a relatively young field that connects neuroscience with empirical aesthetics and originates in the neurological theory of aesthetic experience. It investigates brain structures and activity during the phenomena of artis…
View article: The Biallelic Inheritance of Two Novel SCN1A Variants Results in Developmental and Epileptic Encephalopathy Responsive to Levetiracetam
The Biallelic Inheritance of Two Novel SCN1A Variants Results in Developmental and Epileptic Encephalopathy Responsive to Levetiracetam Open
Loss-, gain-of-function and mixed variants in SCN1A (Nav1.1 voltage-gated sodium channel) have been associated with a spectrum of neurologic disorders with different severity and drug-responsiveness. Most SCN1A variants are heterozygous ch…
View article: ENIGMA-Chronic Pain: a worldwide initiative to identify brain correlates of chronic pain
ENIGMA-Chronic Pain: a worldwide initiative to identify brain correlates of chronic pain Open
International audience
View article: Evaluation of Mild Cognitive Impairment through Perientorhinal/Hippocampal Imaging and Comprehensive Neuropsychological and Psychophysical Assessment
Evaluation of Mild Cognitive Impairment through Perientorhinal/Hippocampal Imaging and Comprehensive Neuropsychological and Psychophysical Assessment Open
Mild cognitive impairment (MCI) is a significant concern as it is a risk factor for AD progression, and early detection is vital in order to delay dementia onset and enable potential therapeutic interventions. Olfactory impairment is recog…
View article: Cognitive reserve and well-being in migraine patients: a multidimensional approach to migraine assessment in an Italian tertiary headache center
Cognitive reserve and well-being in migraine patients: a multidimensional approach to migraine assessment in an Italian tertiary headache center Open
Background: Migraine is a painful neurological condition affecting emotional, cognitive, and daily life functioning. Cognitive reserve (CR) is a protective factor against neurological damage and deterioration, but its proxies have been und…
View article: YAP Ultralate Laser-Evoked Responses in Fibromyalgia: A Pilot Study in Patients with Small Fiber Pathology
YAP Ultralate Laser-Evoked Responses in Fibromyalgia: A Pilot Study in Patients with Small Fiber Pathology Open
Background: The investigation of C-fiber-evoked ultralow-level responses (ULEPs) at somatic sites is difficult in clinical practice but may be useful in patients with small fiber neuropathy. Aim: The aim of the study was to investigate cha…
View article: A Personalized Mediterranean Diet Improves Pain and Quality of Life in Patients with Fibromyalgia
A Personalized Mediterranean Diet Improves Pain and Quality of Life in Patients with Fibromyalgia Open
View article: <scp>Reply to the letter: Headaches during</scp>/<scp>after SARS‐CoV</scp>‐2 <scp>infection</scp>/<scp>vaccination can be primary and secondary as well as acute and chronic,</scp> by Finsterer J and Mehri S
<span>Reply to the letter: Headaches during</span>/<span>after SARS‐CoV</span>‐2 <span>infection</span>/<span>vaccination can be primary and secondary as well as acute and chronic,</span> by Finsterer J and Mehri S Open
Paroxysmal Cerebral Disorders
View article: Exploring Aesthetic Perception in Impaired Aging: A Multimodal Brain—Computer Interface Study
Exploring Aesthetic Perception in Impaired Aging: A Multimodal Brain—Computer Interface Study Open
In the field of neuroscience, brain–computer interfaces (BCIs) are used to connect the human brain with external devices, providing insights into the neural mechanisms underlying cognitive processes, including aesthetic perception. Non-inv…
View article: Auditory mismatch negativity in pre-manifest and manifest Huntington’s disease
Auditory mismatch negativity in pre-manifest and manifest Huntington’s disease Open
An initial and slight decrease in MMN associated with increased phase coherence in the corresponding EEG frequencies could indicate an early functional involvement of pre-attentive resources that could precede the clinical expression of HD.
View article: Headaches and facial pain attributed to SARS‐CoV‐2 infection and vaccination: a systematic review
Headaches and facial pain attributed to SARS‐CoV‐2 infection and vaccination: a systematic review Open
Background and purpose The aim was to provide insights to the characteristics of headache in the context of COVID‐19 on behalf of the Headache Scientific Panel and the Neuro‐COVID‐19 Task Force of the European Academy of Neurology (EAN) an…
View article: Cenobamate as add-on therapy for drug resistant epilepsies: effectiveness, drug to drug interactions and neuropsychological impact. What have we learned from real word evidence?
Cenobamate as add-on therapy for drug resistant epilepsies: effectiveness, drug to drug interactions and neuropsychological impact. What have we learned from real word evidence? Open
Background: Cenobamate (CNB) is an anti-seizure medication (ASM) approved in 2021 in Europe for adjunctive treatment of focal-onset seizures in adults who were not adequately controlled with at least two previous ASMs. Methods: seizure out…
View article: Long-Term Treatment Over 52 Weeks with Monthly Fremanezumab in Drug-Resistant Migraine: A Prospective Multicenter Cohort Study
Long-Term Treatment Over 52 Weeks with Monthly Fremanezumab in Drug-Resistant Migraine: A Prospective Multicenter Cohort Study Open
View article: Gender-related stress factors and emotional perception in migraine: a structured online questionnaire in migraine patients and controls
Gender-related stress factors and emotional perception in migraine: a structured online questionnaire in migraine patients and controls Open
Background While migraine is markedly prevalent in women, gender-related phenotype differences were rarely assessed. For this reason, we investigated, through a multicenter observational cross-sectional study, based on an online questionna…
View article: Editorial: The cognitive neuroscience of empathy and its correlates
Editorial: The cognitive neuroscience of empathy and its correlates Open
EDITORIAL article Front. Hum. Neurosci., 31 October 2023Sec. Cognitive Neuroscience Volume 17 - 2023 | https://doi.org/10.3389/fnhum.2023.1321113
View article: Prefrontal dysfunction in post-COVID-19 hyposmia: an EEG/fNIRS study
Prefrontal dysfunction in post-COVID-19 hyposmia: an EEG/fNIRS study Open
Introduction Subtle cognitive dysfunction and mental fatigue are frequent after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, characterizing the so-called long COVID-19 syndrome. This study aimed to correlate cogn…
View article: Effects of movement congruence on motor resonance in early Parkinson’s disease
Effects of movement congruence on motor resonance in early Parkinson’s disease Open
The observation of action seems to involve the generation of the internal representation of that same action in the observer, a process named motor resonance (MR). The objective of this study was to verify whether an experimental paradigm …
View article: The role of exercise parameters on small extracellular vesicles and microRNAs cargo in preventing neurodegenerative diseases
The role of exercise parameters on small extracellular vesicles and microRNAs cargo in preventing neurodegenerative diseases Open
Physical activity (PA), which includes exercise, can reduce the risk of developing various non-communicable diseases, including neurodegenerative diseases (NDs), and mitigate their adverse effects. However, the mechanisms underlying this a…
View article: Galcanezumab treatment changes visual related EEG connectivity patterns in migraine patients
Galcanezumab treatment changes visual related EEG connectivity patterns in migraine patients Open
Background Monoclonal antibodies against calcitonin gene-related peptides (CGRP) are innovative therapies for migraine treatment. Although they are clinically effective, how anti-CGRP treatment reduces migraine attacks still remains unclea…