Marina E. Hoffmann
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View article: Workflow for E3 Ligase Ligand Validation for PROTAC Development
Workflow for E3 Ligase Ligand Validation for PROTAC Development Open
Proteolysis targeting chimeras (PROTACs) have gained considerable attention as a new modality in drug discovery. The development of PROTACs has been mainly focused on using CRBN (Cereblon) and VHL (Von Hippel-Lindau ligase) E3 ligase ligan…
View article: BRAT1 - a new therapeutic target for glioblastoma
BRAT1 - a new therapeutic target for glioblastoma Open
Glioblastoma (GBM), the most malignant primary brain tumor in adults, has poor prognosis irrespective of therapeutic advances due to its radio-resistance and infiltrative growth into brain tissue. The present study assessed functions and p…
View article: <scp>BAG3</scp> regulates cilia homeostasis of glioblastoma via its <scp>WW</scp> domain
<span>BAG3</span> regulates cilia homeostasis of glioblastoma via its <span>WW</span> domain Open
The multidomain protein BAG3 exerts pleiotropic oncogenic functions in many tumor entities including glioblastoma (GBM). Here, we compared BAG3 protein–protein interactions in either adherently cultured or stem‐like cultured U251 GBM cells…
View article: TBC1D2B undergoes phase separation and mediates autophagy initiation
TBC1D2B undergoes phase separation and mediates autophagy initiation Open
Small ubiquitin‐like modifiers from the ATG8 family regulate autophagy initiation and progression in mammalian cells. Their interaction with LC3‐interacting region (LIR) containing proteins promotes cargo sequestration, phagophore assembly…
View article: Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide
Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide Open
Glioblastoma (GBM) is the most common and most aggressive primary brain tumor, with a very high rate of recurrence and a median survival of 15 months after diagnosis. Abundant evidence suggests that a certain sub-population of cancer cells…
View article: Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases their Susceptibility to Temozolomide
Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases their Susceptibility to Temozolomide Open
: Glioblastoma (GBM) is the most common and most aggressive primary brain tumor with a very high rate of recurrence and a median survival of 15 months after diagnosis. Abundant evi-dence suggests that a certain sub-population of cancer cel…
View article: BAG3 is a negative regulator of ciliogenesis in glioblastoma and triple‐negative breast cancer cells
BAG3 is a negative regulator of ciliogenesis in glioblastoma and triple‐negative breast cancer cells Open
By regulating several hallmarks of cancer, BAG3 exerts oncogenic functions in a wide variety of malignant diseases including glioblastoma (GBM) and triple‐negative breast cancer (TNBC). Here we performed global proteomic/phosphoproteomic a…
View article: Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition
Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition Open
Overexpression of MYC is a genuine cancer driver in lymphomas and related to poor prognosis. However, therapeutic targeting of the transcription factor MYC remains challenging. Here, we show that inhibition of the histone deacetylase 6 (HD…
View article: The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways
The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways Open
The lysosome is a cellular signalling hub at the point of convergence of endocytic and autophagic pathways, where the contents are degraded and recycled. Pleckstrin homology domain‐containing family member 1 (PLEKHM1) acts as an adaptor to…