Marina Mikhaylova
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View article: The Golgi apparatus: adaptations to neuronal shape and functions
The Golgi apparatus: adaptations to neuronal shape and functions Open
The Golgi apparatus is the central hub of secretory and endosomal pathways in a eukaryotic cell. Despite having a conserved basic organization, the Golgi varies greatly in structure and operation mode between different cell types, ranging …
View article: Elevated calneuron-1, an accessory subunit of muscarinic receptors, induces frontotemporal dysconnectivity and schizophrenia-like deficits
Elevated calneuron-1, an accessory subunit of muscarinic receptors, induces frontotemporal dysconnectivity and schizophrenia-like deficits Open
Calneuron-1 is a Ca2+ sensor that has been linked in several genome-wide association studies to schizophrenia (SCZ). We show that calneuron-1 expression is elevated in the dorsolateral prefrontal cortex of SCZ patients and that overexpress…
View article: Myosin VI controls localization of golgi satellites at active presynaptic boutons
Myosin VI controls localization of golgi satellites at active presynaptic boutons Open
Neurons, as long-lived non-dividing cells with complex morphology, depend on a highly elaborate secretory trafficking system which enables a constant turnover of proteins and membranes. Previously, it was shown that simplified, Golgi-relat…
View article: The Molecular Architecture of Somatic Spines of the Lateral Septum
The Molecular Architecture of Somatic Spines of the Lateral Septum Open
The lateral septum is a key subcortical structure and has been implicated in kinship memory. Across species, the ability to recognise relatives is conserved and is reflected in stable, lifelong memories. The molecular mechanisms underlying…
View article: Dynamic regulation of neuronal Vault trafficking and RNA cargo by the noncoding RNA, Vaultrc5
Dynamic regulation of neuronal Vault trafficking and RNA cargo by the noncoding RNA, Vaultrc5 Open
Vaults are large ribonucleoprotein complexes of unknown function in neurons. Here, we report that the Vault-associated noncoding RNA, Vaultrc5, is highly enriched at the synapse and is required for activity-dependent Vault trafficking in n…
View article: Unveiling the cell biology of hippocampal neurons with dendritic axon origin
Unveiling the cell biology of hippocampal neurons with dendritic axon origin Open
In mammalian axon-carrying–dendrite (AcD) neurons, the axon emanates from a basal dendrite, instead of the soma, to create a privileged route for action potential generation at the axon initial segment (AIS). However, it is unclear how suc…
View article: Non-canonical function of ADAM10 in presynaptic plasticity
Non-canonical function of ADAM10 in presynaptic plasticity Open
A Disintegrin And Metalloproteinase 10 (ADAM10) plays a pivotal role in shaping neuronal networks by orchestrating the activity of numerous membrane proteins through the shedding of their extracellular domains. Despite its significance in …
View article: Myosin VI controls localization of Golgi satellites at active presynaptic boutons
Myosin VI controls localization of Golgi satellites at active presynaptic boutons Open
Neurons, as long-living non-dividing cells with complex morphology, depend on highly elaborate secretory trafficking system which ensures the constant delivery, removal and recycling of proteins and membranes. Previously, we have shown tha…
View article: Efficient axonal transport of endolysosomes relies on the balanced ratio of microtubule tyrosination and detyrosination
Efficient axonal transport of endolysosomes relies on the balanced ratio of microtubule tyrosination and detyrosination Open
In neurons, the microtubule (MT) cytoskeleton forms the basis for long-distance protein transport from the cell body into and out of dendrites and axons. To maintain neuronal polarity, the axon initial segment (AIS) serves as a physical ba…
View article: Fundamental Neurochemistry Review: At the intersection between the brain and the immune system: Non‐coding <scp>RNAs</scp> spanning learning, memory and adaptive immunity
Fundamental Neurochemistry Review: At the intersection between the brain and the immune system: Non‐coding <span>RNAs</span> spanning learning, memory and adaptive immunity Open
Non‐coding RNAs (ncRNAs) are highly plastic RNA molecules that can sequester cellular proteins and other RNAs, serve as transporters of cellular cargo and provide spatiotemporal feedback to the genome. Mounting evidence indicates that ncRN…
View article: Efficient axonal trafficking of endolysosomes depends on the balanced ratio of microtubule tyrosination and detyrosination
Efficient axonal trafficking of endolysosomes depends on the balanced ratio of microtubule tyrosination and detyrosination Open
In neurons, the microtubule (MT) cytoskeleton forms the basis for long-distance protein transport from the cell body into and out of dendrites and axon. To maintain neuronal polarity, the axon initial segment (AIS) serves as a physical bar…
View article: Unveiling the cell biology of hippocampal neurons with dendritic axon origin
Unveiling the cell biology of hippocampal neurons with dendritic axon origin Open
Summary In mammalian axon-carrying-dendrite (AcD) neurons, the axon emanates from a basal dendrite, instead of the soma, to create a privileged route for action potential generation at the axon initial segment (AIS). However, it is unclear…
View article: Effects of Tropomodulin 2 on Dendritic Spine Reorganization and Dynamics
Effects of Tropomodulin 2 on Dendritic Spine Reorganization and Dynamics Open
Dendritic spines are actin-rich protrusions that receive a signal from the axon at the synapse. Remodeling of cytoskeletal actin is tightly connected to dendritic spine morphology-mediated synaptic plasticity of the neuron. Remodeling of c…
View article: The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling
The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling Open
Summary: Homeostatic synaptic plasticity adjusts the strength of synapses to restrain neuronal activity within a physiological range. Postsynaptic guanylate kinase-associated protein (GKAP) controls the bidirectional synaptic scaling of AM…
View article: Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology
Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology Open
The vast majority of excitatory synapses are formed on small dendritic protrusions termed dendritic spines. Dendritic spines vary in size and density that are crucial determinants of excitatory synaptic transmission. Aberrations in spine m…
View article: KIF21B binds Myosin Va for Spine Entry and regulates Actin Dynamics to control Homeostatic Synaptic Downscaling
KIF21B binds Myosin Va for Spine Entry and regulates Actin Dynamics to control Homeostatic Synaptic Downscaling Open
Homeostatic synaptic plasticity adjusts the strength of synapses to restrain neuronal activity within a physiological range. Postsynaptic GKAP controls the bidirectional synaptic scaling of AMPA receptors (AMPARs) however how chronic activ…
View article: Regulation of microtubule detyrosination by Ca2+ and conventional calpains
Regulation of microtubule detyrosination by Ca2+ and conventional calpains Open
Detyrosination is a major post-translational modification of microtubules (MTs), which has significant impact on MT function in cell division, differentiation, growth, migration and intracellular trafficking. Detyrosination of α-tubulin oc…
View article: Spike-timing-dependent plasticity rewards synchrony rather than causality
Spike-timing-dependent plasticity rewards synchrony rather than causality Open
Spike-timing-dependent plasticity (STDP) is a candidate mechanism for information storage in the brain, but the whole-cell recordings required for the experimental induction of STDP are typically limited to 1 h. This mismatch of time scale…
View article: Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology
Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology Open
The vast majority of excitatory synapses are formed on small dendritic protrusions termed dendritic spines. Dendritic spines vary in size and density that are both crucial determinants of excitatory synaptic transmission. Aberrations in sp…
View article: Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies
Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies Open
Ligand-stimulated enzymatic release or cellular degradation of PrP may interfere with neurodegeneration-associated toxicity.
View article: Multiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
Multiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment Open
Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to pr…
View article: Calpains are required for efficient microtubule detyrosination
Calpains are required for efficient microtubule detyrosination Open
Detyrosination is a major post-translational modification of microtubules (MT), which has significant impact on MT function in cell division, differentiation, growth, migration, polarity, and intracellular trafficking. Detyrosination of α-…
View article: Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses
Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses Open
Members of the SH3- and ankyrin repeat (SHANK) protein family are considered as master scaffolds of the postsynaptic density of glutamatergic synapses. Several missense mutations within the canonical SHANK3 isoform have been proposed as ca…
View article: Ligands binding to the cellular prion protein induce its protective proteolytic release with therapeutic potential in neurodegenerative proteinopathies
Ligands binding to the cellular prion protein induce its protective proteolytic release with therapeutic potential in neurodegenerative proteinopathies Open
The cellular prion protein (PrP C ) is a central player in neurodegenerative diseases caused by protein misfolding, such as prion diseases or Alzheimer’s disease (AD). Expression levels of this GPI-anchored glycoprotein, especially at the …