Marina Politi Okoshi
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View article: Anti-inflammatory effect of bergamot leaves extract attenuates cardiac remodeling in obese rats by regulating the protein expression of the collagen/metalloproteinase axis
Anti-inflammatory effect of bergamot leaves extract attenuates cardiac remodeling in obese rats by regulating the protein expression of the collagen/metalloproteinase axis Open
Inflammation is associated with the pathogenesis of obesity-related disorders, including cardiac remodeling. Bergamot is known for its promising anti-inflammatory effects. Thus, this study aimed to investigate the anti-inflammatory effect …
View article: Concurrent training and intermittent fasting reduce transverse cross-sectional area of cardiomyocytes and body mass in Wistar rats
Concurrent training and intermittent fasting reduce transverse cross-sectional area of cardiomyocytes and body mass in Wistar rats Open
Methods This study identified the alterations caused by concurrent training and intermittent fasting on the myocardium of rats. In total, 39 adult male Wistar rats were used, divided into four groups: control [C (n = 12)], fasting control …
View article: Lung and Inferior Vena Cava Point-of-Care Ultrasonography, NT-Pro-BNP, and Discharge Body Weight as Predictors of Rehospitalization in Acute Heart Failure
Lung and Inferior Vena Cava Point-of-Care Ultrasonography, NT-Pro-BNP, and Discharge Body Weight as Predictors of Rehospitalization in Acute Heart Failure Open
Background: Patients with acute heart failure exhibit high rates of early rehospitalization accompanied by significant mortality. Therefore, identifying high-risk patients who are prone to disease exacerbation may enable early therapeutic …
View article: Positional Profiling of Anthropometric, Baropodometric, and Grip Strength Traits in Male Volleyball Players: Insights from a National Colombian Study
Positional Profiling of Anthropometric, Baropodometric, and Grip Strength Traits in Male Volleyball Players: Insights from a National Colombian Study Open
Background: In volleyball, upper limb dimensions, handgrip strength (HGS), and baropodometric parameters are critical for executing offensive and defensive actions during the match. These movements demand not only physical precision but al…
View article: Impact of SGLT2i on Cardiac Remodeling and the Soleus Muscle of Infarcted Rats
Impact of SGLT2i on Cardiac Remodeling and the Soleus Muscle of Infarcted Rats Open
Skeletal muscle changes occur in heart failure (HF). Despite the cardioprotective effects of sodium–glucose co-transporter 2 (SGLT2) inhibitors in HF, their impact on skeletal muscle remains poorly understood. We investigated the effects o…
View article: Nlrc4 Inflammasome Expression After Acute Myocardial Infarction in Rats
Nlrc4 Inflammasome Expression After Acute Myocardial Infarction in Rats Open
Acute myocardial necrosis activates the immune response and inflammatory processes. Although the initial response is helpful in restoring tissue injury, dysregulated and exacerbated inflammation contributes to the progression of cardiac re…
View article: The Therapeutic Potential of Orange Juice in Cardiac Remodeling: A Metabolomics Approach
The Therapeutic Potential of Orange Juice in Cardiac Remodeling: A Metabolomics Approach Open
Cardiovascular diseases are a leading cause of death worldwide, and the process of cardiac remodeling lies at the core of most of these diseases. Sustained cardiac remodeling almost unavoidably ends in progressive muscle dysfunction, heart…
View article: Impact of the COVID-19 pandemic on tobacco product consumption and behavioral patterns from a low-middle income country perspective: A qualitative study
Impact of the COVID-19 pandemic on tobacco product consumption and behavioral patterns from a low-middle income country perspective: A qualitative study Open
Behavioral and consumption patterns varied significantly in tobacco users in Brazil during the early stages of the COVID-19 pandemic, ranging from increases to no changes. Individuals consuming tobacco products showed awareness about the h…
View article: Performance of the Nottingham hip fracture score (NHFS) as a predictor of 30-day mortality after proximal femur fracture in an older people Brazilian cohort
Performance of the Nottingham hip fracture score (NHFS) as a predictor of 30-day mortality after proximal femur fracture in an older people Brazilian cohort Open
Perioperative risk assessment helps inform clinical practice for older people with hip fractures. This is a cohort study, where perioperative risk screening, including NHFS, was performed at admission, followed by an evaluation of 30-day o…
View article: Effects of high-intensity interval training on physical performance, systolic blood pressure, oxidative stress and inflammatory markers in skeletal muscle of spontaneously hypertensive rats
Effects of high-intensity interval training on physical performance, systolic blood pressure, oxidative stress and inflammatory markers in skeletal muscle of spontaneously hypertensive rats Open
Aim To investigate whether high-intensity interval training (HIIT) improves physical performance, systolic blood pressure, and markers of oxidative stress and inflammation in skeletal muscle of spontaneously hypertensive rats (SHR). Method…
View article: Cardiomiopatia Diabética: Desvendando Mecanismos Fisiopatológicos por Meio de RNAs não Codificantes
Cardiomiopatia Diabética: Desvendando Mecanismos Fisiopatológicos por Meio de RNAs não Codificantes Open
View article: Avanços em Estresse Oxidativo nas Doenças Cardiovasculares
Avanços em Estresse Oxidativo nas Doenças Cardiovasculares Open
View article: Recent Advances in Oxidative Stress and Cardiovascular Diseases
Recent Advances in Oxidative Stress and Cardiovascular Diseases Open
View article: Diabetic Cardiomyopathy: Unraveling Pathophysiological Mechanisms via Non-coding RNAs
Diabetic Cardiomyopathy: Unraveling Pathophysiological Mechanisms via Non-coding RNAs Open
View article: Influence of CReatine Supplementation on mUScle Mass and Strength After Stroke (ICaRUS Stroke Trial): A Randomized Controlled Trial
Influence of CReatine Supplementation on mUScle Mass and Strength After Stroke (ICaRUS Stroke Trial): A Randomized Controlled Trial Open
Background/Objectives: The acute phase of stroke is marked by inflammation and mobility changes that can compromise nutritional status. This study was a randomized, double-blind, placebo-controlled trial evaluating the effectiveness of cre…
View article: Salivary Metabolomics in Patients with Long COVID-19 Infection
Salivary Metabolomics in Patients with Long COVID-19 Infection Open
Background: Long COVID-19 has been characterized by the presence of symptoms lasting longer than 4 weeks after the acute infection. The pathophysiology of clinical manifestations still lacks knowledge. Objective: The objective of this pape…
View article: Effects of concurrent training and N-acetylcysteine supplementation on cardiac remodeling and oxidative stress in middle-aged spontaneously hypertensive rats
Effects of concurrent training and N-acetylcysteine supplementation on cardiac remodeling and oxidative stress in middle-aged spontaneously hypertensive rats Open
View article: Impact of combined intermittent fasting and high‐intensity interval training on apoptosis and atrophy signaling in rat fast‐ and slow‐twitch muscles
Impact of combined intermittent fasting and high‐intensity interval training on apoptosis and atrophy signaling in rat fast‐ and slow‐twitch muscles Open
This study aimed to evaluate the influence of combined intermittent fasting (IF) and high‐intensity interval training (HIIT) on morphology, caspase‐independent apoptosis signaling pathway, and myostatin expression in soleus and gastrocnemi…
View article: Cardiomiopatia Chagásica Crônica: Influência do Exercício Físico
Cardiomiopatia Chagásica Crônica: Influência do Exercício Físico Open
View article: Chronic Chagasic Cardiomyopathy: Influence of Physical Exercise
Chronic Chagasic Cardiomyopathy: Influence of Physical Exercise Open
View article: Thiamine supplementation in septic shock patients: still looking for the target population
Thiamine supplementation in septic shock patients: still looking for the target population Open
View article: Liraglutide Pretreatment Does Not Improve Acute Doxorubicin-Induced Cardiotoxicity in Rats
Liraglutide Pretreatment Does Not Improve Acute Doxorubicin-Induced Cardiotoxicity in Rats Open
Doxorubicin is an effective drug for cancer treatment; however, cardiotoxicity limits its use. Cardiotoxicity pathophysiology is multifactorial. GLP-1 analogues have been shown to reduce oxidative stress and inflammation. In this study, we…
View article: Myocardial proteome changes in aortic stenosis rats subjected to long‐term aerobic exercise
Myocardial proteome changes in aortic stenosis rats subjected to long‐term aerobic exercise Open
The effects of exercise training (ET) on the heart of aortic stenosis (AS) rats are controversial and the mechanisms involved in alterations induced by ET have been poorly clarified. In this study, we analyzed the myocardial proteome to id…
View article: Pulmonary Arterial Hypertension and Cardioprotective Interventions
Pulmonary Arterial Hypertension and Cardioprotective Interventions Open
View article: Effects of Yerba Mate Consumption (<i>Ilex </i><i>paraguariensis</i>) on Cardiac Remodeling in Rats
Effects of Yerba Mate Consumption (<i>Ilex </i><i>paraguariensis</i>) on Cardiac Remodeling in Rats Open
View article: RNA Não Codificante e Hipertrofia Cardíaca
RNA Não Codificante e Hipertrofia Cardíaca Open
View article: Hipertensão Arterial Pulmonar: Intervenções para Cardioproteção
Hipertensão Arterial Pulmonar: Intervenções para Cardioproteção Open
View article: Long Non-Coding RNA CCAT2 and Pathological Cardiac Remodeling
Long Non-Coding RNA CCAT2 and Pathological Cardiac Remodeling Open
View article: Aspectos morfológicos do músculo gastrocnêmio de ratos submetidos a treinamento intervalado e suplementação com creatina
Aspectos morfológicos do músculo gastrocnêmio de ratos submetidos a treinamento intervalado e suplementação com creatina Open
Introdução: A hipertrofia muscular é definida como aumento na área do corte transverso das fibras, decorrente da síntese/degradação das proteínas. O treinamento intervalado de alta intensidade (HIIT) tem demonstrado ser capaz de promover a…
View article: Methotrexate associated with nanoparticles decreases NLRC4 inflammasome expression in infarcted rat hearts
Methotrexate associated with nanoparticles decreases NLRC4 inflammasome expression in infarcted rat hearts Open
Abstract: Following myocardial infarction (MI), molecules released from necrotic myocytes sensitize nucleotide-binding receptors (NLRs), activate inflammasome complex, and initiate acute inflammatory process and interleukin (IL)-1β product…