Marina S. Hernandes
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View article: Polymerase delta-interacting protein 2 mediates brain vascular permeability by regulating ROS-mediated ZO-1 phosphorylation and localization at the interendothelial border
Polymerase delta-interacting protein 2 mediates brain vascular permeability by regulating ROS-mediated ZO-1 phosphorylation and localization at the interendothelial border Open
These data reveal a novel mitochondrial ROS-driven mechanism by which Poldip2 induces ZO-1 tyrosine phosphorylation and promotes EC permeability following cerebral ischemia.
View article: A Novel Scoring System for Humane Endpoints in Mice with Cecal Ligation and Puncture-Induced Sepsis
A Novel Scoring System for Humane Endpoints in Mice with Cecal Ligation and Puncture-Induced Sepsis Open
Animal-based research is essential to the study of sepsis pathophysiology, diagnostics, and therapeutics. However, animal models of sepsis are often associated with high mortality because of the difficulty in predicting imminent death base…
View article: Role of NADPH Oxidases in Blood–Brain Barrier Disruption and Ischemic Stroke
Role of NADPH Oxidases in Blood–Brain Barrier Disruption and Ischemic Stroke Open
NADPH oxidases (Nox) are one of the main sources of reactive oxygen species (ROS) in the central nervous system (CNS). While these enzymes have been shown to be involved in physiological regulation of cerebral vascular tone, excessive ROS …
View article: Myeloid Poldip2 Contributes to the Development of Pulmonary Inflammation by Regulating Neutrophil Adhesion in a Murine Model of Acute Respiratory Distress Syndrome
Myeloid Poldip2 Contributes to the Development of Pulmonary Inflammation by Regulating Neutrophil Adhesion in a Murine Model of Acute Respiratory Distress Syndrome Open
Background Lung injury, a severe adverse outcome of lipopolysaccharide‐induced acute respiratory distress syndrome, is attributed to excessive neutrophil recruitment and effector response. Poldip2 (polymerase δ‐interacting protein 2) plays…
View article: Characterization of Poldip2 knockout mice: Avoiding incorrect gene targeting
Characterization of Poldip2 knockout mice: Avoiding incorrect gene targeting Open
POLDIP2 is a multifunctional protein whose roles are only partially understood. Our laboratory previously reported physiological studies performed using a mouse gene trap model, which suffered from three limitations: perinatal lethality in…
View article: Endothelial Poldip2 regulates sepsis-induced lung injury via Rho pathway activation
Endothelial Poldip2 regulates sepsis-induced lung injury via Rho pathway activation Open
Aims Sepsis-induced lung injury is associated with significant morbidity and mortality. Previously, we showed that heterozygous deletion of polymerase δ-interacting protein 2 (Poldip2) was protective against sepsis-induced lung injury. Sin…
View article: Characterization of<i>Poldip2</i>knockout mice: avoiding incorrect gene targeting
Characterization of<i>Poldip2</i>knockout mice: avoiding incorrect gene targeting Open
POLDIP2 is a multifunctional protein whose roles are only partially understood. Our laboratory previously reported physiological studies performed using a mouse gene trap model, which suffered from two limitations: perinatal lethality in h…
View article: VE-cadherin endocytosis controls vascular integrity and patterning during development
VE-cadherin endocytosis controls vascular integrity and patterning during development Open
Tissue morphogenesis requires dynamic intercellular contacts that are subsequently stabilized as tissues mature. The mechanisms governing these competing adhesive properties are not fully understood. Using gain- and loss-of-function approa…
View article: Unraveling the Role of Astrocytes in Subthalamic Nucleus Deep Brain Stimulation in a Parkinson’s Disease Rat Model
Unraveling the Role of Astrocytes in Subthalamic Nucleus Deep Brain Stimulation in a Parkinson’s Disease Rat Model Open
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective therapeutic strategy for motor symptoms of Parkinson’s disease (PD) when L-DOPA therapy induces disabling side effects. Classical inflammatory activation of glia…
View article: Poldip2 deficiency protects against lung edema and vascular inflammation in a model of acute respiratory distress syndrome
Poldip2 deficiency protects against lung edema and vascular inflammation in a model of acute respiratory distress syndrome Open
Acute respiratory distress syndrome (ARDS) in a deadly disease that can be brought on by endotoxins such as lipopolysaccharide (LPS). ARDS is characterized by vascular permeability, a severe inflammatory response, lung leukocyte infiltrati…
View article: Nox2-dependent neuroinflammation in an EAE model of multiple sclerosis
Nox2-dependent neuroinflammation in an EAE model of multiple sclerosis Open
Background Multiple sclerosis (MS) is an inflammatory disease of the CNS, characterized by demyelination, focal inflammatory infiltrates and axonal damage. Oxidative stress has been linked to MS pathology. Previous studies have suggested t…
View article: Hernandes et al., 2018.pdf
Hernandes et al., 2018.pdf Open
Polymerase δ-interacting protein 2 (Poldip2) is a multifunctional protein that regulates vascular extracellular matrix composition and matrix metalloproteinase (MMP) activity. The blood-brain barrier (BBB) is a dynamic system assembled by …
View article: Reactive Oxygen Species in Metabolic and Inflammatory Signaling
Reactive Oxygen Species in Metabolic and Inflammatory Signaling Open
Reactive oxygen species (ROS) are well known for their role in mediating both physiological and pathophysiological signal transduction. Enzymes and subcellular compartments that typically produce ROS are associated with metabolic regulatio…
View article: Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain
Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain Open
Poldip2 is upregulated following ischemic stroke and mediates the breakdown of the BBB by increasing cerebral cytokine production and MMP activation. Therefore, Poldip2 appears to be a promising novel target for the development of therapeu…
View article: Polymerase δ-interacting Protein 2: A Multifunctional Protein
Polymerase δ-interacting Protein 2: A Multifunctional Protein Open
Polymerase δ-interacting protein 2 (Poldip2) is a multifunctional protein originally described as a binding partner of the p50 subunit of DNA polymerase δ and proliferating cell nuclear antigen. In addition to its role in DNA replication a…