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View article: Cost-effectiveness analysis of screening for congenital Chagas disease in a non-endemic area
Cost-effectiveness analysis of screening for congenital Chagas disease in a non-endemic area Open
Chagas disease (CD) is an emerging public health concern in Europe. In non-endemic countries, congenital transmission is the main route of new infections. Italy is the second-largest host country in Europe for Latin American migrants and t…
View article: Blood donation in young people: estimation of education and awareness in Rome high school students using translated questionnaires
Blood donation in young people: estimation of education and awareness in Rome high school students using translated questionnaires Open
Background: Ensuring a stable blood supply is a critical public health challenge, with young adults representing a vital pool of potential donors. Education and awareness are key to fostering positive attitudes and behaviors toward blood d…
View article: Drugs Misuse in custodial settings: a systematic review and meta-analysis
Drugs Misuse in custodial settings: a systematic review and meta-analysis Open
Background: Increasing evidence suggests that custodial settings are at risk for the misuse of psychoactive drugs (DM) outside their prescription. The purpose of this systematic review and meta-analysis was to determine the extent of this …
View article: Mortality and admissions for cerebrovascular and cardiovascular diseases after the Accumoli-Amatrice 2016 earthquake
Mortality and admissions for cerebrovascular and cardiovascular diseases after the Accumoli-Amatrice 2016 earthquake Open
Objective The aim of this study is to evaluate if the mortality and hospital admissions for cerebrovascular and cardiovascular diseases (CCVDs), with a specific focus on acute myocardial infarction (AMI), significantly increased within 12 …
View article: Ranking Nursing Diagnoses by Predictive Relevance for Intensive Care Unit Transfer Risk in Adult and Pediatric Patients: A Machine Learning Approach with Random Forest
Ranking Nursing Diagnoses by Predictive Relevance for Intensive Care Unit Transfer Risk in Adult and Pediatric Patients: A Machine Learning Approach with Random Forest Open
Background/Objectives: In hospital settings, the wide variability of acute and complex chronic conditions—among both adult and pediatric patients—requires advanced approaches to detect early signs of clinical deterioration and the risk of …
View article: A Comparison of Machine Learning-Based Models and a Simple Clinical Bedside Tool to Predict Morbidity and Mortality After Gastrointestinal Cancer Surgery in the Elderly
A Comparison of Machine Learning-Based Models and a Simple Clinical Bedside Tool to Predict Morbidity and Mortality After Gastrointestinal Cancer Surgery in the Elderly Open
Frailty in the elderly population is associated with increased vulnerability to stressors, including surgical interventions. This study compared machine learning (ML) models with a clinical bedside tool, the Gastrointestinal Surgery Frailt…
View article: Implementing mHealth Apps Through Community Engagement to Promote Cancer Screening: A Scoping Review
Implementing mHealth Apps Through Community Engagement to Promote Cancer Screening: A Scoping Review Open
Background/Objectives: Colorectal (CRC), breast (BC), and cervical cancer (CC) pose a significant health burden, yet screening programs have been proven to reduce cancer-specific mortality and other non-lethal endpoints. Mobile health (mHe…
View article: Nursing Complexity and Health Literacy as Determinants of Patient Outcomes: A Prospective One-Year Multicenter Cohort Study
Nursing Complexity and Health Literacy as Determinants of Patient Outcomes: A Prospective One-Year Multicenter Cohort Study Open
Background/Objectives: Although nursing complexity and health literacy (HL) are critical determinants of patient outcomes, their combined impact on mortality, hospital re-admissions, and emergency department (ED) visits remains poorly unde…
View article: An Innovative Device for the Hot Water Circuit in Hospitals to Save Energy Without Compromising the Safety and Quality of Water: Preliminary Results
An Innovative Device for the Hot Water Circuit in Hospitals to Save Energy Without Compromising the Safety and Quality of Water: Preliminary Results Open
Legionella colonization of water systems represents a potential hazard for humans within healthcare facilities. It is possible to contain its spread through continuous disinfection systems and the correct management and maintenance of the …
View article: Health Professionals’ Preferences for Next-Generation Sequencing in the Diagnosis of Suspected Genetic Disorders in the Paediatric Population
Health Professionals’ Preferences for Next-Generation Sequencing in the Diagnosis of Suspected Genetic Disorders in the Paediatric Population Open
Background/Objectives: Next-generation sequencing (NGS) can explain how genetics influence morbidity and mortality in children. However, it is unclear whether health providers will perceive and use such treatments. We conducted a discrete …
View article: Institutionalization of Health Technology Assessment of medical devices: a cluster analysis of EU, EEA, and EFTA countries
Institutionalization of Health Technology Assessment of medical devices: a cluster analysis of EU, EEA, and EFTA countries Open
Objectives Health technology assessment of medical devices (HTA-MDs) presents unique challenges compared to pharmaceuticals. Total MD expenditure continues to grow in Europe, and countries typically conduct their own HTA-MDs evaluations, w…
View article: Co-administration of COVID-19 and flu vaccines in healthcare workers: results from three campaigns
Co-administration of COVID-19 and flu vaccines in healthcare workers: results from three campaigns Open
The COVID-19 pandemic, along with seasonal influenza, highlights the need for innovative public health strategies. Co-administering COVID-19 and influenza vaccines offers advantages for healthcare workers (HCWs), streamlining vaccination e…
View article: Cost-effectiveness analysis of Chagas disease screening in pregnant women and their infants in Italy
Cost-effectiveness analysis of Chagas disease screening in pregnant women and their infants in Italy Open
Background Currently, Chagas disease (CD) is widespread in European nations that host notable populations from Latin America. Vertical transmission is a pathway for the spread of the disease in countries where it is not endemic. Due to soc…
View article: From crisis to chronic: a comparative analysis of Long COVID impact in Italy and the United States
From crisis to chronic: a comparative analysis of Long COVID impact in Italy and the United States Open
Background The aftermath of COVID-19 is bringing about socio-economic consequences, such as diminished quality of life (QoL), decreased productivity, and considerable healthcare expenditures. Despite the emerging acknowledgment of a clinic…
View article: Screening for congenital Chagas disease in a non-endemic area: a cost-effectiveness analysis
Screening for congenital Chagas disease in a non-endemic area: a cost-effectiveness analysis Open
Background Due to climate changes, immigration, and globalization, Chagas Disease (CD) also afflicts nations without vector transmission. In Europe, congenital CD (cCD) is a significant public health issue, perpetuating the disease: it is …
View article: Exploring the Impact of Medical Complexity on Nursing Complexity of Care in Paediatric Patients: A Retrospective Observational Study
Exploring the Impact of Medical Complexity on Nursing Complexity of Care in Paediatric Patients: A Retrospective Observational Study Open
Aims To explore the impact of medical complexity, defined by the number of chronic conditions, on the complexity of care, as described by the frequency of nursing diagnoses (NDs) and nursing actions (NAs), in paediatric patients. Design Re…
View article: An ecological comparison to inspect the aftermath of post COVID-19 condition in Italy and the United States
An ecological comparison to inspect the aftermath of post COVID-19 condition in Italy and the United States Open
Post COVID-19 Condition (PCC) is a clinical syndrome following COVID-19 disease. PCC symptoms in adults entail significant productivity loss and reduced quality of life. This study aimed at estimating the epidemiological and economic burde…
View article: The Impact of Socio-Economic Conditions on Individuals’ Health: Development of an Index and Examination of its Association with Three of the Most Frequently Registered Diseases in Lazio Region of Italy
The Impact of Socio-Economic Conditions on Individuals’ Health: Development of an Index and Examination of its Association with Three of the Most Frequently Registered Diseases in Lazio Region of Italy Open
This study examines spatial disparities and associations between the social deprivation index (SDI) and Type 2 Diabetes, Dementia, and Heart Failure in Italy’s Lazio Region. The primary goal is to assess how social deprivation impacts heal…
View article: Hospital waste management before and during COVID-19 pandemic: An analysis of the environmental impact of CO <sub>2</sub> emissions in four Italian facilities
Hospital waste management before and during COVID-19 pandemic: An analysis of the environmental impact of CO <sub>2</sub> emissions in four Italian facilities Open
The COVID-19 pandemic caused a surge in hospital waste (HW), posing an urgent public and environmental health challenge. Although a safe HW disposal method, high temperature incineration of fossil-derived materials contributes to air pollu…
View article: Pediatric post COVID-19 condition: an umbrella review of the most common symptoms and associated factors
Pediatric post COVID-19 condition: an umbrella review of the most common symptoms and associated factors Open
Background Although the long-term consequences of the Coronavirus Disease-2019 (COVID-19) pandemic are yet to be fully comprehended, a syndrome symptomatically akin to the COVID-19 disease has been defined, for children and adolescents, in…
View article: Cost-Effectiveness of Whole-Genome vs Whole-Exome Sequencing Among Children With Suspected Genetic Disorders
Cost-Effectiveness of Whole-Genome vs Whole-Exome Sequencing Among Children With Suspected Genetic Disorders Open
Importance The diagnosis of rare diseases and other genetic conditions can be daunting due to vague or poorly defined clinical features that are not recognized even by experienced clinicians. Next-generation sequencing technologies, such a…
View article: Me.Si. Mr Acs: An Innovative Device for the Hot Water Circuit in Hospitals to Save Energy Without Compromising the Safety and Quality of Water
Me.Si. Mr Acs: An Innovative Device for the Hot Water Circuit in Hospitals to Save Energy Without Compromising the Safety and Quality of Water Open
View article: Co-administration of SARS-CoV-2 and influenza vaccines in healthcare workers: Results of two vaccination campaigns in a large teaching hospital in Rome
Co-administration of SARS-CoV-2 and influenza vaccines in healthcare workers: Results of two vaccination campaigns in a large teaching hospital in Rome Open
The concurrent administration of COVID-19 and influenza vaccines has arisen as a promising approach to bolster protection against respiratory pathogens and improve vaccination rates. However, there remains a lack of data regarding the prev…
View article: Bayesian cost-effectiveness analysis of Whole genome sequencing versus Whole exome sequencing in a pediatric population with suspected genetic disorders
Bayesian cost-effectiveness analysis of Whole genome sequencing versus Whole exome sequencing in a pediatric population with suspected genetic disorders Open
Genetic diseases are medical conditions caused by sequence or structural changes in an individual’s genome. Whole exome sequencing (WES) and whole genome sequencing (WGS) are increasingly used for diagnosing suspected genetic conditions in…
View article: Cost–utility of cardiac contractility modulation in patients with heart failure with reduced ejection fraction in Italy
Cost–utility of cardiac contractility modulation in patients with heart failure with reduced ejection fraction in Italy Open
Aims Cardiac contractility modulation (CCM) is a device therapy for heart failure, based on the delivery of high‐voltage biphasic impulses to the right ventricular septum during the myocardial absolute refractory period. This study evaluat…
View article: The role of hybrid immunity after the administration of the first booster dose
The role of hybrid immunity after the administration of the first booster dose Open
COVID-19 vaccines have been shown to be safe, effective and life-saving. However, the advent of the Omicron variant has greatly impacted the effectiveness of vaccination and the transmissibility of the virus requiring the analysis of the d…
View article: Counting the Cost: The Economic Toll of Discrimination Against LGBTQAI+ Individuals in Italy
Counting the Cost: The Economic Toll of Discrimination Against LGBTQAI+ Individuals in Italy Open
This study investigates the financial consequences of perceived discrimination towards LGBTQAI+ people in Italy, focusing on psychological support and medication costs. It highlights the burden of discriminatory experiences, emphasizing th…
View article: Cost-effectiveness analysis of Next generation sequencing tests in critically ill pediatric patients
Cost-effectiveness analysis of Next generation sequencing tests in critically ill pediatric patients Open
Rare genetic diseases in the pediatric population constitute an urgent global public health issue; overall, more than 300 million people are affected worldwide. Next Generation Sequencing techniques, as Whole genome sequencing (WGS) and Wh…
View article: Post COVID-19 Condition in adults: results from a bibliometric analysis
Post COVID-19 Condition in adults: results from a bibliometric analysis Open
Background Post COVID-19 Condition (PCC) in adults, as defined by the WHO, is a newly discovered syndrome consisting of symptoms persisting for at least two months and arising usually three months after SARS-CoV-2 infection. Among the over…
View article: Organizational Aspects of the Implementation and Use of Whole Genome Sequencing and Whole Exome Sequencing in the Pediatric Population in Italy: Results of a Survey
Organizational Aspects of the Implementation and Use of Whole Genome Sequencing and Whole Exome Sequencing in the Pediatric Population in Italy: Results of a Survey Open
This study explores the organizational aspects of whole genome sequencing (WGS) implementation for pediatric patients with suspected genetic disorders in Italy, comparing it with whole exome sequencing (WES). Health professionals’ opinions…