Carlos Platas‐Iglesias
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View article: Novel chelators for radiolanthanum coordination chemistry
Novel chelators for radiolanthanum coordination chemistry Open
View article: Chemical Tools to Characterize the Coordination Chemistry of Radionuclides for Radiopharmaceutical Applications
Chemical Tools to Characterize the Coordination Chemistry of Radionuclides for Radiopharmaceutical Applications Open
During the past decade, the advancement and approval of novel radiopharmaceuticals for clinical application has led to a resurgence of the field of radiochemistry and specifically the coordination chemistry of radionuclides. In addition to…
View article: A pentanuclear iridium(III) hydride cluster: aggregation of an iridium(I) precatalyst
A pentanuclear iridium(III) hydride cluster: aggregation of an iridium(I) precatalyst Open
The crystal structure of a unique pentanuclear Ir cluster, tetrakis[1,3-bis(2,4,6-trimethylphenyl)-1,3-dihydro-2 H -imidazol-2-ylidene-κ C 2 ]carbonyldi-μ 3 -hydrido-tetra-μ 2 -hydrido-nonahydridopentairidium(III), [Ir 5 (μ 3 -H) 2 (μ 2 -H…
View article: Decadentate Acyclic Chelators for Lanthanum Radiopharmaceuticals
Decadentate Acyclic Chelators for Lanthanum Radiopharmaceuticals Open
Two decadentate acyclic chelators bearing four picolinic acid groups appended on either an ethylenediamine (H4TPAEN) or a trans-1,2-cyclohexyldiamine (H4TPADAC) unit were explored as candidates for lanthanum-ba…
View article: Design of Mn(1,4-DO2A) derivatives as stable and inert contrast agents for magnetic resonance imaging
Design of Mn(1,4-DO2A) derivatives as stable and inert contrast agents for magnetic resonance imaging Open
Manganese(II) is considered a valuable alternative to gadolinium(III) in developing contrast agents (CAs) for magnetic resonance imaging (MRI). However, due to the labile nature of common Mn(II) complexes, designing ligands that enable sta…
View article: A Water Stable U(IV) Complex Based on a Macrocyclic Ligand Displaying NIR Emission
A Water Stable U(IV) Complex Based on a Macrocyclic Ligand Displaying NIR Emission Open
Complexation of U(IV) by encapsulation into the cavity of a 1,4,7‐triazacyclonane (tacn) macrocycle functionalized by phosphonated pyridyl arms affords a water‐stable and soluble [U(IV)L] complex. The coordination process was monitored by …
View article: Corrigendum: Incorporation of Carboxylate Pendant Arms Into 18‐Membered Macrocycles: Effects on [<sup>nat/203</sup>Pb]Pb(II) Complexation
Corrigendum: Incorporation of Carboxylate Pendant Arms Into 18‐Membered Macrocycles: Effects on [<sup>nat/203</sup>Pb]Pb(II) Complexation Open
View article: Exploring the chemistry of H2DEDPA derivatives for [nat/68Ga]Ga3+ complexation
Exploring the chemistry of H2DEDPA derivatives for [nat/68Ga]Ga3+ complexation Open
We report a detailed study of the coordination chemistry of acyclic hexadentate H2DEDPA derivatives towards [nat/68Ga]Ga3+ (H2DEDPA = 6,6'-((ethane-1,2-diylbis(azanediyl))bis(methylene))dipicolin…
View article: Exploring the Coordination Chemistry and Potential Applications of PC3PA-Based Lanthanide Complexes: Synthesis, Solution Structure, Luminescence, and Relaxation Properties
Exploring the Coordination Chemistry and Potential Applications of PC3PA-Based Lanthanide Complexes: Synthesis, Solution Structure, Luminescence, and Relaxation Properties Open
The novel ligand H3PC3PA was synthesized from pyclen and methyl-6-(bromomethyl)picolinate with 82% overall yield, and its rare-earth complexes (La, Eu, Gd, Tb, Lu, Y) were isolated and characterized by HR-MS and analytica…
View article: From electron spin to relaxivity: a multidisciplinary perspective on first-row transition metal-based MRI probes
From electron spin to relaxivity: a multidisciplinary perspective on first-row transition metal-based MRI probes Open
EPR spectroscopy complements NMR and DFT in designing next-generation MRI contrast agents based on first-row transition metals, providing key molecular parameters for reliable interpretation of relaxometric data.
View article: Correction: Exploring the use of rigid 18-membered macrocycles with amide pendant arms for Pb(<scp>ii</scp>)-based radiopharmaceuticals
Correction: Exploring the use of rigid 18-membered macrocycles with amide pendant arms for Pb(<span>ii</span>)-based radiopharmaceuticals Open
Correction for ‘Exploring the use of rigid 18-membered macrocycles with amide pendant arms for Pb( ii )-based radiopharmaceuticals’ by Charlene Harriswangler et al. , Inorg. Chem. Front. , 2024, 11 , 1070–1086, https://doi.org/10.1039/D3QI…
View article: Lanthanide complexes bearing a bioinspired Cu <sup>II</sup> binding site with picomolar affinity: synthesis, structural, relaxometric and luminescence studies
Lanthanide complexes bearing a bioinspired Cu <sup>II</sup> binding site with picomolar affinity: synthesis, structural, relaxometric and luminescence studies Open
Two Ln III -DO3A-C3AmpicGH complexes (Ln III = Gd III , Eu III ) exhibit high affinity for Cu II and high selectivity over Zn II . The Eu III complex shows a luminescence turn-off response upon Cu II binding, whereas the Gd III complex rem…
View article: Phosphorus chirality assignment and solution dynamics of lanthanide( <scp>iii</scp> ) complexes of a monomethylphosphinate analogue of H <sub>4</sub> dota: a multinuclear NMR and DFT study
Phosphorus chirality assignment and solution dynamics of lanthanide( <span>iii</span> ) complexes of a monomethylphosphinate analogue of H <sub>4</sub> dota: a multinuclear NMR and DFT study Open
Orientation of the substituents of the coordinated phosphinate group was experimentally determined for the first time and exchange between its coordinated/non-coordinated oxygen atoms (“phosphinate rotation”) was experimentally/computation…
View article: Fluoride binding in unlikely partners: the formation of anion–anion complexes with [M(EGTA)]<sup>−</sup> and [M(OBETA)]<sup>−</sup> (M = Gd<sup>3+</sup>, Y<sup>3+</sup>)
Fluoride binding in unlikely partners: the formation of anion–anion complexes with [M(EGTA)]<sup>−</sup> and [M(OBETA)]<sup>−</sup> (M = Gd<sup>3+</sup>, Y<sup>3+</sup>) Open
Fluoride binding to anionic rare-earth complexes with the formation of mono- and di-nuclear entities has been established by using a combination of high- and low-resolution NMR techniques and DFT calculations.
View article: A Bioinspired Cu<sup>2+</sup>-Responsive Magnetic Resonance Imaging Contrast Agent with Unprecedented Turn-On Response and Selectivity
A Bioinspired Cu<sup>2+</sup>-Responsive Magnetic Resonance Imaging Contrast Agent with Unprecedented Turn-On Response and Selectivity Open
Imaging extracellular Cu2+ in vivo is of paramount interest due to its biological importance in both physiological and pathological states. Magnetic resonance imaging (MRI) is a powerful technique to do so. However, the developm…
View article: Tuning the Properties of Rigidified Acyclic DEDPA<sup>2–</sup> Derivatives for Application in PET Using Copper-64
Tuning the Properties of Rigidified Acyclic DEDPA<sup>2–</sup> Derivatives for Application in PET Using Copper-64 Open
We present a detailed investigation of the coordination chemistry toward [natCu/64Cu]copper of a series of H2DEDPA derivatives (H2DEDPA = 6,6'-((ethane-1,2-diylbis(azanediyl))bis(methylene))dipic…
View article: Evaluation of structurally related acyclic ligands OBETA, EHDTA, and EGTA for stable Mn<sup>2+</sup> complex formation
Evaluation of structurally related acyclic ligands OBETA, EHDTA, and EGTA for stable Mn<sup>2+</sup> complex formation Open
Structurally related heptadentate (OBETA, EHDTA) and octadentate (EGTA) ligands form Mn 2+ complexes that exhibit distinct characteristics in terms of relaxivity, thermodynamic stability, and, most notably, kinetic inertness.
View article: Dynamics of Lanthanide(III) complexes from crystallographic data and computational studies
Dynamics of Lanthanide(III) complexes from crystallographic data and computational studies Open
View article: Trapping Highly Reactive Metal(H)<sub>2</sub>(<i>η</i><sup>2</sup>‐H<sub>2</sub>) Species to Form Trihydride Complexes and Clusters
Trapping Highly Reactive Metal(H)<sub>2</sub>(<i>η</i><sup>2</sup>‐H<sub>2</sub>) Species to Form Trihydride Complexes and Clusters Open
Metal dihydride dihydrogen‐derived intermediates can be short‐lived and difficult to detect despite their ubiquitous role in chemical transformations such as hydrogenation. Here, highly reactive [Ir(H) 3 (η 2 ‐η 2 ‐COD)(IMes)] forms by tra…
View article: Improving the In Vivo Stability of [<sup>52</sup>Mn]Mn(II) Complexes with 18-Membered Macrocyclic Chelators for PET Imaging
Improving the In Vivo Stability of [<sup>52</sup>Mn]Mn(II) Complexes with 18-Membered Macrocyclic Chelators for PET Imaging Open
We report the [natMn/52Mn]Mn(II) complexes of the macrocyclic chelators PYAN [3,6,10,13-tetraaza-1,8(2,6)-dipyridinacyclotetradecaphane] and CHXPYAN [(41R,42R,101R…
View article: Taylor dispersion analysis for measurement of diffusivity and size of gadolinium-based contrast agents
Taylor dispersion analysis for measurement of diffusivity and size of gadolinium-based contrast agents Open
Gadolinium-based contrast agents (GBCA) are complexes of a Gadolinium metal center and a linear or macrocyclic polyamino-carboxylic acid chelating agent. These agents are employed to enhance the visibility of deep abnormalities through MRI…
View article: Relevance of Oxocyclam from Palladium(II) Coordination to Radiopharmaceutical Development
Relevance of Oxocyclam from Palladium(II) Coordination to Radiopharmaceutical Development Open
We provide a comprehensive study of the coordination of oxocyclam with palladium(II), including presentation of a novel bifunctional analogue, p-H2N-Bn-oxocyclam, bearing an aniline pendant. Th…
View article: Using Chiral Auxiliaries to Mimic the Effect of Chiral Media on the Structure of Lanthanide(III) Complexes Common in Bioimaging and Diagnostic MRI
Using Chiral Auxiliaries to Mimic the Effect of Chiral Media on the Structure of Lanthanide(III) Complexes Common in Bioimaging and Diagnostic MRI Open
[Ln·DOTA]- complexes and systems derived therefrom are commonly used in MRI and optical bioimaging. These lanthanide(III) complexes are chiral, and, in solution, they are present in four forms, with two sets of enantiomers, with…
View article: Incorporation of Carboxylate Pendant Arms into 18‐Membered Macrocycles: Effects on [<sup>nat/203</sup>Pb]Pb(II) Complexation
Incorporation of Carboxylate Pendant Arms into 18‐Membered Macrocycles: Effects on [<sup>nat/203</sup>Pb]Pb(II) Complexation Open
We present a detailed investigation on the coordination chemistry of [ nat/203 Pb]Pb(II) with chelators H 4 PYTA and H 4 CHX ‐PYTA. These chelators belong to the family of ligands derived from the 18‐membered macrocyclic backbone PYAN and …
View article: O-versus S-Metal Coordination of the Thiocarboxylate Group: An NMR Study of the Two Tautomeric Forms of the Ga(III)-Photoxenobactin E Complex
O-versus S-Metal Coordination of the Thiocarboxylate Group: An NMR Study of the Two Tautomeric Forms of the Ga(III)-Photoxenobactin E Complex Open
Photoxenobactin E (1) is a natural product with an unusual thiocarboxylic acid terminus recently isolated from an entomopathogenic bacterium. The biosynthetic gene cluster associated with photoxenobactin E, and other reported deriva…
View article: Surprising Impact of Donor Charge on the Water Exchange Rates of Gd(III) AAZTA Derivatives
Surprising Impact of Donor Charge on the Water Exchange Rates of Gd(III) AAZTA Derivatives Open
We report the synthesis of three new heptadentate ligands derived from H 4 AAZTA (6‐amino‐6‐methylperhydro‐1,4‐diazepinetetraacetic acid) that contain a dimethyl‐amide group (AAZTA‐MA) 3− , two dimethyl‐amide groups (AAZTA‐BMA) 2− or two a…
View article: Using Chiral Auxiliaries to Mimic the Effect of Chiral Media on the Structure of Lanthanide(III) Complexes Common in Bioimaging and Diagnostic MRI
Using Chiral Auxiliaries to Mimic the Effect of Chiral Media on the Structure of Lanthanide(III) Complexes Common in Bioimaging and Diagnostic MRI Open
[Ln·DOTA]- complexes, and systems derived therefrom, are commonly used in MRI and optical bioimaging. These lanthanide(III) complexes are chiral and, in solution, they are present in eight forms, two sets of four uncapped and four capped f…
View article: CCDC 2296480: Experimental Crystal Structure Determination
CCDC 2296480: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2296481: Experimental Crystal Structure Determination
CCDC 2296481: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2305214: Experimental Crystal Structure Determination
CCDC 2305214: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …