Mario Cocco
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View article: Burden and Clinical Characteristics of Influenza and Its Complications in Children Across Multiple Epidemic Seasons
Burden and Clinical Characteristics of Influenza and Its Complications in Children Across Multiple Epidemic Seasons Open
Seasonal influenza is a major cause of morbidity and hospitalization in children, with the potential for severe complications and considerable socioeconomic impact. We conducted a retrospective observational study including 1046 children a…
Effects of efgartigimod treatment on humoral and cellular immune responses: analysis of T-cell-dependent antibody response in cynomolgus monkeys Open
Efgartigimod is a human IgG1 antibody Fc fragment that reduces IgG levels through neonatal Fc receptor blockade. This study evaluated whether efgartigimod affects the generation of T-cell-dependent antibodies and cellular immune responses …
Immunophenotypical characterization of immune checkpoint receptor expression in cynomolgus monkeys and human healthy volunteers in resting and in T-cell stimulatory conditions <i>in vitro</i> Open
Immunotherapeutics targeting immune checkpoint receptors or their ligands (i.e., immune checkpoint inhibitors), have been groundbreaking in the field of oncology, radically changing the approach to treatment and improving the clinical outc…
View article: A dichotomy of gene regulatory associations during the activated B-cell to plasmablast transition
A dichotomy of gene regulatory associations during the activated B-cell to plasmablast transition Open
The activated B-cell (ABC) to plasmablast transition encompasses the cusp of antibody-secreting cell (ASC) differentiation. We explore this transition with integrated analysis in human cells, focusing on changes that follow removal from CD…
View article: A dichotomy in association of core transcription factors and gene regulation during the activated B-cell to plasmablast transition
A dichotomy in association of core transcription factors and gene regulation during the activated B-cell to plasmablast transition Open
The activated B-cell (ABC) to plasmablast transition is the cusp of antibody secreting cell (ASC) differentiation but is incompletely defined. We apply expression time-courses, parsimonious gene correlation network analysis, and ChIP-seq t…
Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity Open
The unfolded protein response (UPR) and activation of XBP1 is necessary for high secretory efficiency and functional differentiation of antibody secreting cells (ASCs). The UPR additionally includes a branch in which membrane-bound transcr…
Serological Surveillance and Direct Field Searching Reaffirm the Absence of<i>Ornithodoros Erraticus</i>Ticks Role in African Swine Fever Cycle in Sardinia Open
African swine fever (ASF), one of the most important diseases of swine, has been endemic in the Italian island of Sardinia for more than 35 years. During these decades, several strategies and eradication efforts have been implemented in th…