Elia Biganzoli
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View article: Expression of antibody-drug conjugate targets in post-mortem samples of breast cancer metastases and normal tissue
Expression of antibody-drug conjugate targets in post-mortem samples of breast cancer metastases and normal tissue Open
While many Antibody Drug Conjugates (ADCs) are investigated in solid tumors, their target expression and heterogeneity is poorly documented in metastatic breast cancer. Here, we perform RNA sequencing to investigate expression of 72 ADC ta…
View article: The role of body mass index at diagnosis in patients with inflammatory breast cancer
The role of body mass index at diagnosis in patients with inflammatory breast cancer Open
We observed a limited association of BMI with clinicopathological variables and pCR in patients with IBC without evidence of its relationship with survival outcomes. Future studies should investigate the biological impact of obesity on IBC…
View article: Rationale and study protocol of the MAMELI Cohort study (Mapping the Methylation of repetitive elements to track the Exposome effects on health: the city of Legnano as a Living lab)
Rationale and study protocol of the MAMELI Cohort study (Mapping the Methylation of repetitive elements to track the Exposome effects on health: the city of Legnano as a Living lab) Open
The concept of the exposome encompasses all the factors influencing human health throughout the life course. The exposome induces epigenetic changes, such as DNA methylation, which influence gene expression and impact overall health. Sever…
View article: Association of HER2-low with clinicopathological features in patients with early invasive lobular breast cancer: an international multicentric study
Association of HER2-low with clinicopathological features in patients with early invasive lobular breast cancer: an international multicentric study Open
HER2-low is present in more than half of the patients with early ER+ HER2- pure ILCs and is associated with larger tumor size and multifocality. HER2-low is associated with a worse DFS and OS as compared to HER2 0.
View article: Rationale and study protocol of the MAMELI Cohort study (MApping the Methylation of repetitive elements to track the Exposome effects on health: the city of Legnano as a LIving lab)
Rationale and study protocol of the MAMELI Cohort study (MApping the Methylation of repetitive elements to track the Exposome effects on health: the city of Legnano as a LIving lab) Open
Background The concept of the exposome encompasses all the factors influencing human health throughout the life course. The exposome induces epigenetic changes, such as DNA methylation, which influence gene expression and impact overall he…
View article: Histopathological Insights into Metastatic Breast Cancer Gained From Rapid Autopsies
Histopathological Insights into Metastatic Breast Cancer Gained From Rapid Autopsies Open
The biology of metastatic breast cancer is poorly understood, and its understanding is hampered by limited access to metastatic tissue. Post-mortem tissue donation programs may represent a step forward to circumvent this problem, allowing …
View article: Redundancy, noise, and plasticity: repetitive DNA as an epigenetic intelligence backbone of inflammatory regulation
Redundancy, noise, and plasticity: repetitive DNA as an epigenetic intelligence backbone of inflammatory regulation Open
Background: Repetitive DNA elements such as LINE1 have been proposed to support a redundant distributed, adaptive layer of gene regulation, contributing to “Epigenetic Intelligence” (EI). However, empirical evidence for their role in modul…
View article: When cells think: a neuro-symbolic view of epigenetic regulation
When cells think: a neuro-symbolic view of epigenetic regulation Open
Traditionally viewed as a set of switches regulating gene expression, epigenetic mechanisms may also operate as an information-processing system with symbolic and subsymbolic features. In this framework, gene-specific DNA methylation and o…
View article: COVID-19 Pandemic's Effects on Occupational Health and Perceived Work Ability of a Large Group of Italian Banking Employees
COVID-19 Pandemic's Effects on Occupational Health and Perceived Work Ability of a Large Group of Italian Banking Employees Open
Background: The COVID-19 pandemic compelled changes to the structure and organization of many occupational sectors that may impact workers' well-being and work-related symptoms. Objective: Evaluate the effects of working modifications rela…
View article: Assessing Lifestyle in a Large Cohort of Undergraduate Students: Significance of Stress, Exercise and Nutrition
Assessing Lifestyle in a Large Cohort of Undergraduate Students: Significance of Stress, Exercise and Nutrition Open
Background/Objectives: Lifestyle (in particular, nutrition and exercise) determines present and future youths’ health. The goal of the present study was to identify specific student groups who deserve precise lifestyle improvement interven…
View article: Medical and scientific evidence for the cancer attractor
Medical and scientific evidence for the cancer attractor Open
While linear gene-based and focused explanations of cancer development, growth, and spread have totally dominated cancer investigations for a century, these accounts utterly fail to adequately explain many critical host–cancer interactions…
View article: Lung function trajectories in children with early diagnosis of non-cystic fibrosis bronchiectasis: a retrospective observational study
Lung function trajectories in children with early diagnosis of non-cystic fibrosis bronchiectasis: a retrospective observational study Open
Background Non-cystic fibrosis (non-CF) bronchiectasis (BE) is defined as a clinical syndrome of recurrent, persistent wet cough and abnormal bronchial dilatation on chest High Resolution Computed Tomography (HRCT) scans. The aims of this …
View article: 60P Expression of antibody-drug conjugate targets in metastatic breast cancer
60P Expression of antibody-drug conjugate targets in metastatic breast cancer Open
Three Antibody-Drug Conjugates (ADCs), targeting HER2 or TROP2, are approved for metastatic breast cancer (mBC). ADCs targeting another 55 targets are currently being clinically studied in solid tumors. Here, we investigated the expression…
View article: HEBE project: Healthy aging versus inflamm-aging: The role of physical exercise in modulating the biomarkers of age-associated and environmentally determined chronic diseases, study protocol
HEBE project: Healthy aging versus inflamm-aging: The role of physical exercise in modulating the biomarkers of age-associated and environmentally determined chronic diseases, study protocol Open
Inflamm-aging refers to the chronic low-grade inflammation that occurs with aging and cellular senescence, and it is linked to various diseases. Understanding the markers involved in inflammation and aging, as well as their interaction wit…
View article: The Effectiveness of the Third Dose of COVID-19 Vaccine: When Should It Be Performed?
The Effectiveness of the Third Dose of COVID-19 Vaccine: When Should It Be Performed? Open
Background: COVID-19 vaccination is the most significant step toward the long-term mitigation of SARS-CoV-2-related complication, avoiding disease and death and decreasing virus spread. This study aimed to evaluate, in a real-world setting…
View article: Abstract A004: Comparison of ctDNA detection in seven different types of body liquids from patients with metastatic breast cancer
Abstract A004: Comparison of ctDNA detection in seven different types of body liquids from patients with metastatic breast cancer Open
Background. Liquid biopsies represent a less invasive alternative to tissue biopsy to characterize the disease in patients with metastatic cancer. Blood remains the most frequently investigated body liquid with regards to detection, quanti…
View article: Supplementary Figure 4 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy
Supplementary Figure 4 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy Open
Supplementary Figure 4 shows an overview of tumor emboli assessment.
View article: Supplementary Figure 14 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy
Supplementary Figure 14 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy Open
Supplementary Figure 14 shows analyses of the association of sTIL with DRFS.
View article: Supplementary Figure 10 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy
Supplementary Figure 10 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy Open
Supplementary Figure 10 shows analyses of the association of pCR with DRFS.
View article: Supplementary Figure 13 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy
Supplementary Figure 13 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy Open
Supplementary Figure 13 shows analyses of the association of sTIL with DFS and OS.
View article: FIGURE 2 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy
FIGURE 2 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy Open
Association of pCR with clinicopathologic features and treatment in all patients. A–C, Forest plots showing the association of pCR with standard clinicopathologic and treatment variables (A), with sTILs (continuous %; B), and with sTILs (c…
View article: Supplementary Table 1 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy
Supplementary Table 1 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy Open
Supplementary Table 1 shows clinicopathological characteristics of the entire cohort and the sub-cohort with central pathology performed.
View article: Supplementary Figure 3 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy
Supplementary Figure 3 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy Open
Supplementary Figure 3 shows concordance of sTIL scoring between tumor and skin biopsies.
View article: Supplementary Figure 7 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy
Supplementary Figure 7 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy Open
Supplementary Figure 7 shows subgroup analyses of the association of pCR with clinicopathological and treatment variables.