Mario Gomez-Salazar
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View article: Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality
Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality Open
Enhancing thermogenic brown adipose tissue (BAT) function is a promising therapeutic strategy for metabolic disease. However, predominantly thermoneutral modern human living conditions deactivate BAT. We demonstrate that selective adipocyt…
View article: Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing
Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing Open
Summary The profound pain accompanying bone fracture is mediated by somatosensory neurons, which also appear to be required to initiate bone regeneration following fracture. Surprisingly, the precise neuroanatomical circuitry mediating ske…
View article: Tppp3+ synovial/tendon sheath progenitor cells contribute to heterotopic bone after trauma
Tppp3+ synovial/tendon sheath progenitor cells contribute to heterotopic bone after trauma Open
Heterotopic ossification (HO) is a pathological process resulting in aberrant bone formation and often involves synovial lined tissues. During this process, mesenchymal progenitor cells undergo endochondral ossification. Nonetheless, the s…
View article: <i>ZIC1</i> Dictates Osteogenesis Versus Adipogenesis in Human Mesenchymal Progenitor Cells Via a Hedgehog Dependent Mechanism
<i>ZIC1</i> Dictates Osteogenesis Versus Adipogenesis in Human Mesenchymal Progenitor Cells Via a Hedgehog Dependent Mechanism Open
Numerous intrinsic factors regulate mesenchymal progenitor commitment to a specific cell fate, such as osteogenic or adipogenic lineages. Identification and modulation of novel intrinsic regulatory factors represent an opportunity to harne…
View article: Aldehyde Dehydrogenase, a Marker of Normal and Malignant Stem Cells, Typifies Mesenchymal Progenitors in Perivascular Niches
Aldehyde Dehydrogenase, a Marker of Normal and Malignant Stem Cells, Typifies Mesenchymal Progenitors in Perivascular Niches Open
Innate mesenchymal stem cells exhibiting multilineage differentiation and tissue (re)generative—or pathogenic—properties reside in perivascular niches. Subsets of these progenitors are committed to either osteo-, adipo-, or fibrogenesis, s…
View article: TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate
TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate Open
Pericytes are multipotent mesenchymal precursor cells that demonstrate tissue-specific properties. In this study, by comparing human adipose tissue- and periosteum-derived pericyte microarrays, we identified T cell lymphoma invasion and me…
View article: Protocol to analyze and validate transcriptomic changes in PDGFRβ-KO mesenchymal stem cell osteogenic potential in the mouse embryo
Protocol to analyze and validate transcriptomic changes in PDGFRβ-KO mesenchymal stem cell osteogenic potential in the mouse embryo Open
Mesenchymal stem/stromal cells (MSCs) can differentiate into osteoblasts under appropriate conditions. PDGFRβ signaling controls MSC osteogenic potential both transcriptomically and in culture. Here, we present a "computer to the bench" pr…
View article: CNTNAP4 signaling regulates osteosarcoma disease progression
CNTNAP4 signaling regulates osteosarcoma disease progression Open
Improved treatment strategies for sarcoma rely on clarification of the molecular mediators of disease progression. Recently, we reported that the secreted glycoprotein NELL-1 modulates osteosarcoma (OS) disease progression in part via alte…
View article: CNTNAP4 signaling regulates osteosarcoma disease progression
CNTNAP4 signaling regulates osteosarcoma disease progression Open
Improved treatment strategies for sarcoma rely on clarification of the molecular mediators of disease progression. Recently, we reported that the secreted glycoprotein NELL-1 modulates osteosarcoma (OS) disease progression in part via alte…
View article: Contemporary perspectives on heterotopic ossification
Contemporary perspectives on heterotopic ossification Open
Heterotopic ossification (HO) is the formation of ectopic bone that is primarily genetically driven (fibrodysplasia ossificans progressiva [FOP]) or acquired in the setting of trauma (tHO). HO has undergone intense investigation, especiall…
View article: NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression
NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression Open
Sarcomas produce an abnormal extracellular matrix (ECM), which in turn provides instructive cues for cell growth and invasion. Neural EGF like-like molecule 1 (NELL1) is a secreted glycoprotein characterized by its nonneoplastic osteoinduc…
View article: Bone-Forming Perivascular Cells: Cellular Heterogeneity and Use for Tissue Repair
Bone-Forming Perivascular Cells: Cellular Heterogeneity and Use for Tissue Repair Open
Mesenchymal progenitor cells are broadly distributed across perivascular niches—an observation conserved between species. One common histologic zone with a high frequency of mesenchymal progenitor cells within mammalian tissues is the tuni…
View article: Innate Immune Cells in the Adipose Tissue in Health and Metabolic Disease
Innate Immune Cells in the Adipose Tissue in Health and Metabolic Disease Open
Metabolic disorders, such as obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver disease, are characterized by chronic low-grade tissue and systemic inflammation. During obesity, the adipose tissue undergoes immunometabolic and…
View article: Adipocyte-specific deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality
Adipocyte-specific deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality Open
Enhancing brown adipose tissue (BAT) function to combat metabolic disease is a promising therapeutic strategy. A major obstacle to this strategy is that a thermoneutral environment, relevant to most modern human living conditions, deactiva…
View article: Five Decades Later, Are Mesenchymal Stem Cells Still Relevant?
Five Decades Later, Are Mesenchymal Stem Cells Still Relevant? Open
Mesenchymal stem cells are culture-derived mesodermal progenitors isolatable from all vascularized tissues. In spite of multiple fundamental, pre-clinical and clinical studies, the native identity and role in tissue repair of MSCs have lon…
View article: Human Adipose Tissue Micro-fragmentation for Cell Phenotyping and Secretome Characterization
Human Adipose Tissue Micro-fragmentation for Cell Phenotyping and Secretome Characterization Open
In the past decade, adipose tissue transplants have been widely used in plastic surgery and orthopaedics to enhance tissue repletion and/or regeneration. Accordingly, techniques for harvesting and processing human adipose tissue have evolv…
View article: Comparison of Human Tissue Microarray to Human Pericyte Transcriptome Yields Novel Perivascular Cell Markers
Comparison of Human Tissue Microarray to Human Pericyte Transcriptome Yields Novel Perivascular Cell Markers Open
Human perivascular progenitor cells, including pericytes, are well-described multipotent mesenchymal cells giving rise to mesenchymal stem cells in culture. Despite the unique location of pericytes, specific antigens to distinguish human p…