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View article: The (un)known crosstalk between metabolism and mechanotransduction: Implications for metabolic syndrome (MetS)-associated neurological complications
The (un)known crosstalk between metabolism and mechanotransduction: Implications for metabolic syndrome (MetS)-associated neurological complications Open
Metabolic syndrome (MetS) has been associated with disruptions in tissue mechanical homeostasis and inflammatory and metabolic derangements. However, the direct correlation between metabolic alterations and changes in tissue stiffness, and…
View article: Physioxia-modulated mesenchymal stem cells secretome has higher capacity to preserve neuronal network and translation processes in hypoxic-ischemic encephalopathy in vitro model
Physioxia-modulated mesenchymal stem cells secretome has higher capacity to preserve neuronal network and translation processes in hypoxic-ischemic encephalopathy in vitro model Open
Hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of child death worldwide. Most of the survivors develop various neurological diseases, such as cerebral palsy, seizures, and/or motor and behavioral problems. HIE is caused…
View article: Readaptation of mesenchymal stem cells to high stiffness and oxygen environments modulate the extracellular matrix
Readaptation of mesenchymal stem cells to high stiffness and oxygen environments modulate the extracellular matrix Open
The therapeutic potential of mesenchymal stem cells (MSCs) has been explored over the past decades due to their ability to modulate the microenvironment through paracrine signaling. Consequently, the secretome of MCSs has emerged as a cell…
View article: Mimicking physiological stiffness or oxygen levels in vitro reorganizes mesenchymal stem cells machinery toward a more naïve phenotype
Mimicking physiological stiffness or oxygen levels in vitro reorganizes mesenchymal stem cells machinery toward a more naïve phenotype Open
Mesenchymal stem cells (MSCs) offer a promising therapeutic potential for a wide variety of pathologies. However, obtaining minimal effective doses requires an extensive in vitro expansion, which compromises their stemness and therapeutic …
View article: Biomarkers of hypoxic–ischemic encephalopathy: a systematic review
Biomarkers of hypoxic–ischemic encephalopathy: a systematic review Open
Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early hours lack objective measurement tools. Therefore, this systematic review aims to identify putative molecules that can be used in diagnosis in daily cl…
View article: Hypothermia Does Not Boost the Neuroprotection Promoted by Umbilical Cord Blood Cells in a Neonatal Hypoxia-Ischemia Rat Model
Hypothermia Does Not Boost the Neuroprotection Promoted by Umbilical Cord Blood Cells in a Neonatal Hypoxia-Ischemia Rat Model Open
Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of death and long-term disability in the perinatal period. Currently, therapeutic hypothermia is the standard of care for this condition with modest efficacy and s…
View article: Modulation of signaling pathways by DJ-1: An updated overview
Modulation of signaling pathways by DJ-1: An updated overview Open
View article: Posttranslational modifications of proteins are key features in the identification of CSF biomarkers of multiple sclerosis
Posttranslational modifications of proteins are key features in the identification of CSF biomarkers of multiple sclerosis Open
View article: Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies
Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies Open
Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of mortality and morbidity in the perinatal period. This condition results from a period of ischemia and hypoxia to the brain of neonates, leading to several disorders th…
View article: Induced pluripotent stem cell-derived vascular networks to screen nano–bio interactions
Induced pluripotent stem cell-derived vascular networks to screen nano–bio interactions Open
The vascular bioactivity/safety of nanomaterials is typically evaluated by animal testing, which is of low throughput and does not account for biological differences between animals and humans such as ageing, metabolism and disease profile…
View article: Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury
Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury Open
View article: Cofilin-1 Is a Mechanosensitive Regulator of Transcription
Cofilin-1 Is a Mechanosensitive Regulator of Transcription Open
The mechanical properties of the extracellular environment are interrogated by cells and integrated through mechanotransduction. Many cellular processes depend on actomyosin-dependent contractility, which is influenced by the microenvironm…
View article: A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson’s disease potential biomarkers
A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson’s disease potential biomarkers Open
View article: Additional file 5 of A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson’s disease potential biomarkers
Additional file 5 of A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson’s disease potential biomarkers Open
Additional file 5: Supplementary Table 3. Evaluation of the total levels of the secreted proteins under control and stress conditions.
View article: Additional file 6 of A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson’s disease potential biomarkers
Additional file 6 of A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson’s disease potential biomarkers Open
Additional file 6: Supplementary Table 4. Evaluation of the total levels of the plasma proteins of Controls and Parkinson’s disease patients.
View article: Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction
Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction Open
View article: Corrigendum to “oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening” [Redox Biology (2019) 101130]
Corrigendum to “oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening” [Redox Biology (2019) 101130] Open
View article: oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening
oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening Open
View article: A generic normalization method for proper quantification in untargeted proteomics screening
A generic normalization method for proper quantification in untargeted proteomics screening Open
The label-free quantitative mass spectrometry methods, in particular, the SWATH-MS approach, have gained popularity and became a powerful technique for comparison of large datasets. In the present work, it is introduced the use of recombin…
View article: Modulation of Oligodendrocyte Differentiation by Mechanotransduction
Modulation of Oligodendrocyte Differentiation by Mechanotransduction Open
Oligodendrocytes (OLs) are responsible for the myelination of axons in the central nervous system (CNS). The differentiation of OLs encompasses several stages, through which cells undergo dramatic biochemical and morphological changes. OL …
View article: Modulation of oligodendrocyte differentiation and maturation by combined biochemical and mechanical cues
Modulation of oligodendrocyte differentiation and maturation by combined biochemical and mechanical cues Open
View article: Antimycin A disturbs mESC neuronal differentiation.
Antimycin A disturbs mESC neuronal differentiation. Open
mESCs differentiated for 14 days into dopaminergic neurons using a PA6-based system were treated with AA since day 2. Representative phase contrast microscopy images were obtained at different time-points of the process (days 7, 10 and 14)…
View article: Lysophosphatidic acid enhances survival of human CD34+ cells in ischemic conditions
Lysophosphatidic acid enhances survival of human CD34+ cells in ischemic conditions Open
Several clinical trials are exploring therapeutic effect of human CD34 + cells in ischemic diseases, including myocardial infarction. Unfortunately, most of the cells die few days after delivery. Herein we show that lysophosphatidic acid (…
View article: Oxidative stress dependent regulation of DJ-1: An interactomic point of view
Oxidative stress dependent regulation of DJ-1: An interactomic point of view Open