Mario J. Rebecchi
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View article: Impact of left bundle branch block morphology in predicting response to left bundle branch area pacing for cardiac resynchronization therapy
Impact of left bundle branch block morphology in predicting response to left bundle branch area pacing for cardiac resynchronization therapy Open
Background Left bundle branch area pacing (LBBAP) is a novel pacing technique with an emerging role in resynchronization therapy [1-4]. QRS morphology has shown to significantly influence cardiac resynchronization therapy (CRT) response [5…
View article: Contribution of T-Type Calcium Channels to Spinal Cord Injury-Induced Hyperexcitability of Nociceptors
Contribution of T-Type Calcium Channels to Spinal Cord Injury-Induced Hyperexcitability of Nociceptors Open
A hyperexcitable state and spontaneous activity of nociceptors have been suggested to play a critical role in the development of chronic neuropathic pain following spinal cord injury (SCI). In male rats, we employed the action potential-cl…
View article: Presynaptic Inhibition of Primary Nociceptive Signals to Dorsal Horn Lamina I Neurons by Dopamine
Presynaptic Inhibition of Primary Nociceptive Signals to Dorsal Horn Lamina I Neurons by Dopamine Open
The dorsal horn of the spinal cord represents the first relay station in the pain pathway where primary nociceptive inputs are modulated by local circuits and by descending signals before being relayed to supraspinal nuclei. To determine w…
View article: Contribution of diacylglycerol lipase β to pain after surgery
Contribution of diacylglycerol lipase β to pain after surgery Open
DAGLβ is not the principal enzyme that controls 2-AG derived AA and PGE2 production after surgery, and inhibitors targeting this enzyme are unlikely to be efficacious analgesics superior to those already approved to treat acute postoperati…
View article: Presynaptic inhibition of transient receptor potential vanilloid type 1 (TRPV1) receptors by noradrenaline in nociceptive neurons
Presynaptic inhibition of transient receptor potential vanilloid type 1 (TRPV1) receptors by noradrenaline in nociceptive neurons Open
Key points The transient receptor potential vanilloid type 1 (TRPV1) receptor is a polymodal molecular integrator in the pain pathway expressed in Aδ‐ and C‐fibre nociceptors and is responsible for the thermal hyperalgesia associated with …
View article: Additional file 3: of Transcriptomic evidence of a para-inflammatory state in the middle aged lumbar spinal cord
Additional file 3: of Transcriptomic evidence of a para-inflammatory state in the middle aged lumbar spinal cord Open
Differentially expressed gene set. Description: all annotated genes included in the differentially expressed gene set that were included in the pathway analysis. (XLSX 38Â kb)
View article: Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms
Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms Open
Background Fatty-acid-binding proteins (FABPs) are intracellular carriers for endocannabinoids, N-acylethanolamines, and related lipids. Previous work indicates that systemically administered FABP5 inhibitors produce analgesia in models of…
View article: Additional file 2: of Transcriptomic evidence of a para-inflammatory state in the middle aged lumbar spinal cord
Additional file 2: of Transcriptomic evidence of a para-inflammatory state in the middle aged lumbar spinal cord Open
Up and down modulated genes. Description: all genes significantly up or down modulated in LSC comparing young to middle-aged LSC. (XLSX 445Â kb)
View article: Dopamine modulation of transient receptor potential vanilloid type 1 (TRPV1) receptor in dorsal root ganglia neurons
Dopamine modulation of transient receptor potential vanilloid type 1 (TRPV1) receptor in dorsal root ganglia neurons Open
Key points Transient receptor potential vanilloid type 1 (TRPV1) receptors transduce noxious thermal stimuli and are responsible for the thermal hyperalgesia associated with inflammatory pain. A large population of dorsal root ganglia (DRG…
View article: Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age
Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age Open
Prior studies of aging and neuropathic injury have focused on senescent animals compared to young adults, while changes in middle age, particularly in the dorsal root ganglia (DRG), have remained largely unexplored. 14 neuroimmune mRNA mar…
View article: Leptin Levels Are Negatively Correlated with 2-Arachidonoylglycerol in the Cerebrospinal Fluid of Patients with Osteoarthritis
Leptin Levels Are Negatively Correlated with 2-Arachidonoylglycerol in the Cerebrospinal Fluid of Patients with Osteoarthritis Open
In the patient sample investigated, there is a negative association between 2-AG and leptin levels in the CSF. This is consistent with pre-clinical studies in animals, demonstrating that leptin controls the levels of hypothalamic endocanna…
View article: Endocannabinoids and acute pain after total knee arthroplasty
Endocannabinoids and acute pain after total knee arthroplasty Open
Osteoarthritis (OA) of the knee is a progressive disease that is associated with inflammation of the joints and lower extremity pain. Total knee arthroplasty (TKA) is a surgical procedure that aims to reduce pain and restore motor function…
View article: Fatty Acid Binding Protein Deletion Suppresses Inflammatory Pain through Endocannabinoid/<i>N</i>-Acylethanolamine-Dependent Mechanisms
Fatty Acid Binding Protein Deletion Suppresses Inflammatory Pain through Endocannabinoid/<i>N</i>-Acylethanolamine-Dependent Mechanisms Open
Background Fatty acid binding proteins (FABPs) serve as intracellular carriers that deliver endocannabinoids and N-acylethanolamines to their catabolic enzymes. Inhibition of FABPs reduces endocannabinoid transport and catabolism in cells …