Mario Jacques
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View article: An inducible BRCA1 expression system with <i>in vivo</i> applicability uncovers activity of the combination of ATR and PARP inhibitors to overcome therapy resistance
An inducible BRCA1 expression system with <i>in vivo</i> applicability uncovers activity of the combination of ATR and PARP inhibitors to overcome therapy resistance Open
Poly(ADP-ribose) polymerase inhibitors (PARPi) have transformed cancer therapy for patients harbouring homologous recombination repair (HRR) deficiencies, notably BRCA1/2 mutations. However, resistance to PARPi remains a clinical challenge…
View article: Preventive Effects of Ocimum gratissimum (Lamiaceae) Leaf Decoction on Pilocarpine-induced Seizure and Anxiety in White Mice (Mus musculus Swiss)
Preventive Effects of Ocimum gratissimum (Lamiaceae) Leaf Decoction on Pilocarpine-induced Seizure and Anxiety in White Mice (Mus musculus Swiss) Open
The objective of this work was to evaluate the effects of leaf decoction of Ocimum gratissimum (24.4, 61, 122 and 244 mg/kg) on seizures and anxiety during pilocarpine-induced epileptogenesis in mice Mus musculus Swiss. To evaluate anticon…
View article: Visualization of Staphylococcus Aureus in the Bovine Mammary Gland by Fluorescence in Situ Hybridization
Visualization of Staphylococcus Aureus in the Bovine Mammary Gland by Fluorescence in Situ Hybridization Open
View article: Biofilm Formation in Dairy: A Food Safety Concern—Recent progress in antibiofilm strategies in the dairy industry
Biofilm Formation in Dairy: A Food Safety Concern—Recent progress in antibiofilm strategies in the dairy industry Open
Biofilm formation allows microorganisms including bacteria to persist on abiotic or biotic surfaces, to resist treatments with biocides (disinfectants and antibiotics), and to evade the immune response in animal hosts much more than they d…
View article: One Health—One Biofilm
One Health—One Biofilm Open
View article: Untargeted and targeted metabolomics reveal that adenosine nucleotides released in Actinobacillus pleuropneumoniae supernatant inhibit porcine reproductive and respiratory syndrome virus replication
Untargeted and targeted metabolomics reveal that adenosine nucleotides released in Actinobacillus pleuropneumoniae supernatant inhibit porcine reproductive and respiratory syndrome virus replication Open
View article: Counteracting Bacterial Motility: A Promising Strategy to Narrow Listeria monocytogenes Biofilm in Food Processing Industry
Counteracting Bacterial Motility: A Promising Strategy to Narrow Listeria monocytogenes Biofilm in Food Processing Industry Open
Listeria monocytogenes ( L. monocytogenes ) is often associated with processed food as it can form biofilms that represent a source of contamination at all stages of the manufacturing chain. The control and prevention of biofilms in food-p…
View article: Identification and preliminary characterization of a 75-kDa hemin- and hemoglobin-binding outer membrane protein of Actinobacillus pleuropneumoniae serotype 1
Identification and preliminary characterization of a 75-kDa hemin- and hemoglobin-binding outer membrane protein of Actinobacillus pleuropneumoniae serotype 1 Open
The reference strains representing serotypes 1 to 12 of Actinobacillus pleuropneumoniae biotype 1 were examined for their ability to utilize porcine hemoglobin (Hb) or porcine hemin (Hm) as iron sources for growth. In a growth promotion as…
View article: Actinobacillus pleuropneumoniae Interaction With Swine Endothelial Cells
Actinobacillus pleuropneumoniae Interaction With Swine Endothelial Cells Open
Actinobacillus pleuropneumonia is a swine (host) specific respiratory pathogen and the etiological agent of swine pleuropneumonia which affects pigs of all ages, many being asymptomatic carriers. This pathogen has high morbidity and…
View article: A Siderophore Analog of Fimsbactin from Acinetobacter Hinders Growth of the Phytopathogen Pseudomonas syringae and Induces Systemic Priming of Immunity in Arabidopsis thaliana
A Siderophore Analog of Fimsbactin from Acinetobacter Hinders Growth of the Phytopathogen Pseudomonas syringae and Induces Systemic Priming of Immunity in Arabidopsis thaliana Open
Siderophores produced in soil by plant growth-promoting rhizobacteria (PGPRs) play several roles, including nutrient mobilizers and can be useful as plants defense elicitors. We investigated the role of a synthetic mixed ligand bis-catecho…
View article: Quality control of blood smears prepared on transparent methanol: an alternative method for the microscopic diagnosis of malaria.
Quality control of blood smears prepared on transparent methanol: an alternative method for the microscopic diagnosis of malaria. Open
View article: Prevalence and characteristics of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) isolated from chicken meat in the province of Quebec, Canada
Prevalence and characteristics of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) isolated from chicken meat in the province of Quebec, Canada Open
This study was conducted to estimate the prevalence of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) in retail chicken meat and broiler chickens from the Province of Quebec, Canada, and to characterize LA-MRSA …
View article: Regulation of <i>waaH</i> by PhoB during P <sub>i</sub> Starvation Promotes Biofilm Formation by Escherichia coli O157:H7
Regulation of <i>waaH</i> by PhoB during P <sub>i</sub> Starvation Promotes Biofilm Formation by Escherichia coli O157:H7 Open
Enterohemorrhagic Escherichia coli O157:H7 is a human pathogen that causes bloody diarrhea that can result in renal failure. Outside of mammalian hosts, E. coli O157:H7 survives for extended periods of time in nutrient-poor environments, l…
View article: The Mastitis Pathogens Culture Collection
The Mastitis Pathogens Culture Collection Open
The Mastitis Pathogen Culture Collection contains more than 16,000 mastitis-causing bacterial isolates from milk samples taken from cow quarters and bulk tanks in a national cohort of 91 dairy farms across Canada over a period of 2 years. …
View article: <i>Escherichia coli</i>O157:H7 responds to phosphate starvation by modifying LPS involved in biofilm formation
<i>Escherichia coli</i>O157:H7 responds to phosphate starvation by modifying LPS involved in biofilm formation Open
In open environments such as water, enterohemorrhagic Escherichia coli O157:H7 responds to inorganic phosphate (Pi) starvation by inducing the Pho regulon controlled by PhoB. The phosphate-specific transport (Pst) system is the high-affini…
View article: Short communication: Search for superantigen genes in coagulase-negative staphylococci isolated from bovine milk in Canada
Short communication: Search for superantigen genes in coagulase-negative staphylococci isolated from bovine milk in Canada Open
The objective of the present study was to look for genes encoding for superantigens in bovine coagulase-negative staphylococci (CNS) isolated from milk in Canada. We screened by PCR 71 bovine CNS isolates, obtained from the Mastitis Pathog…
View article: Incorporation of Actinobacillus pleuropneumoniae in Preformed Biofilms by Escherichia coli Isolated From Drinking Water of Swine Farms
Incorporation of Actinobacillus pleuropneumoniae in Preformed Biofilms by Escherichia coli Isolated From Drinking Water of Swine Farms Open
Actinobacillus pleuropneumoniae, the etiological agent of porcine pleuropneumonia, represents one of the most important health problems in the swine industry worldwide and it is included in the porcine respiratory disease complex. O…
View article: N-Acetyl-glucosamine influences the biofilm formation of Escherichia coli
N-Acetyl-glucosamine influences the biofilm formation of Escherichia coli Open
View article: Invited review: Incidence, risk factors, and effects of clinical mastitis recurrence in dairy cows
Invited review: Incidence, risk factors, and effects of clinical mastitis recurrence in dairy cows Open
Clinical mastitis (CM) is one of the most frequent and costly diseases in dairy cows. A frustrating aspect of CM is its recurrent nature. This review was conducted to synthesize knowledge on risk of repeated cases of CM, effects of recurre…
View article: <i>Actinobacillus pleuropneumoniae</i>biofilms: Role in pathogenicity and potential impact for vaccination development
<i>Actinobacillus pleuropneumoniae</i>biofilms: Role in pathogenicity and potential impact for vaccination development Open
Actinobacillus pleuropneumoniae is a Gram-negative bacterium that belongs to the family Pasteurellaceae . It is the causative agent of porcine pleuropneumonia, a highly contagious respiratory disease that is responsible for major economic …
View article: Interactions of Intestinal Bacteria with Components of the Intestinal Mucus
Interactions of Intestinal Bacteria with Components of the Intestinal Mucus Open
The human gut is colonized by a variety of large amounts of microbes that are collectively called intestinal microbiota. Most of these microbial residents will grow within the mucus layer that overlies the gut epithelium and will act as th…
View article: Coagulase-negative staphylococci species affect biofilm formation of other coagulase-negative and coagulase-positive staphylococci
Coagulase-negative staphylococci species affect biofilm formation of other coagulase-negative and coagulase-positive staphylococci Open
Coagulase-negative staphylococci (CNS) are considered to be commensal bacteria in humans and animals, but are now also recognized as etiological agents in several infections, including bovine mastitis. Biofilm formation appears to be an im…
View article: Impact of Nutrient Restriction on the Structure of Listeria monocytogenes Biofilm Grown in a Microfluidic System
Impact of Nutrient Restriction on the Structure of Listeria monocytogenes Biofilm Grown in a Microfluidic System Open
Biofilm formation by the pathogen Listeria monocytogenes is a major concern in food industries. The aim of this work was to elucidate the effect of nutrient limitation on both biofilm architecture and on the viability of the bacteri…
View article: Antibiofilm and antibacterial effects of specific chitosan molecules on Staphylococcus aureus isolates associated with bovine mastitis
Antibiofilm and antibacterial effects of specific chitosan molecules on Staphylococcus aureus isolates associated with bovine mastitis Open
Staphylococcus aureus is one of the major pathogens causing bovine intramammary infections (IMIs) and mastitis. Mastitis is the primary cause for the use of antibiotics in dairy farms but therapeutic failure is often observed. One of the r…
View article: Biofilm formation and antimicrobial resistance genes of coagulase-negative staphylococci isolated from cows with mastitis in Argentina
Biofilm formation and antimicrobial resistance genes of coagulase-negative staphylococci isolated from cows with mastitis in Argentina Open
Mastitis affects the health and welfare of dairy cows worldwide. Coagulase-negative staphylococci (CNS) are known to form biofilms and are increasingly recognized as a cause of persistent bovine intramammary infections. A total of 90 CNS i…
View article: <i>Actinobacillus pleuropneumoniae</i> grows as aggregates in the lung of pigs: is it time to refine our <i>in vitro</i> biofilm assays?
<i>Actinobacillus pleuropneumoniae</i> grows as aggregates in the lung of pigs: is it time to refine our <i>in vitro</i> biofilm assays? Open
Summary Actinobacillus pleuropneumoniae causes porcine pleuropneumonia and forms biofilms in vitro on abiotic surfaces; however, presence of biofilms during infections has not been documented. The aim of this study was to use a species‐spe…
View article: Auxotrophic Actinobacillus pleurpneumoniae grows in multispecies biofilms without the need for nicotinamide-adenine dinucleotide (NAD) supplementation
Auxotrophic Actinobacillus pleurpneumoniae grows in multispecies biofilms without the need for nicotinamide-adenine dinucleotide (NAD) supplementation Open
View article: Impact of <i>Actinobacillus pleuropneumoniae</i> biofilm mode of growth on the lipid A structures and stimulation of immune cells
Impact of <i>Actinobacillus pleuropneumoniae</i> biofilm mode of growth on the lipid A structures and stimulation of immune cells Open
Actinobacillus pleuropneumoniae (APP), the etiologic agent of porcine pleuropneumonia, forms biofilms on biotic and abiotic surfaces. APP biofilms confers resistance to antibiotics. To our knowledge, no studies have examined the role of AP…
View article: Comparative transcriptomic analysis of<i>Clostridium perfringens</i>biofilms and planktonic cells
Comparative transcriptomic analysis of<i>Clostridium perfringens</i>biofilms and planktonic cells Open
Clostridium perfringens is an opportunistic pathogen that can cause food poisoning in humans and various enterotoxaemias in animal species. Recently, C. perfringens was shown to form biofilms, a structured community of bacterial cells encl…
View article: Biofilm-Forming Abilities of Shiga Toxin-Producing Escherichia coli Isolates Associated with Human Infections
Biofilm-Forming Abilities of Shiga Toxin-Producing Escherichia coli Isolates Associated with Human Infections Open
Forming biofilms may be a survival strategy of Shiga toxin-producing Escherichia coli to enable it to persist in the environment and the food industry. Here, we evaluate and characterize the biofilm-forming ability of 39 isolates of Shiga …