Mario Kofler
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View article: Liberalization of the Systemic Glucose Management is Associated with a Reduced Frequency of Neuroglucopenia in Subarachnoid Hemorrhage Patients: An Observational Cohort Study
Liberalization of the Systemic Glucose Management is Associated with a Reduced Frequency of Neuroglucopenia in Subarachnoid Hemorrhage Patients: An Observational Cohort Study Open
Background Pathologically low brain glucose levels, referred to as neuroglucopenia, are associated with unfavorable outcomes in neurocritical care patients. We sought to investigate whether an increase in serum glucose levels would be asso…
View article: Cognitive, Mental Health, Functional, and Quality of Life Outcomes 1 Year After Spontaneous Subarachnoid Hemorrhage: A Prospective Observational Study
Cognitive, Mental Health, Functional, and Quality of Life Outcomes 1 Year After Spontaneous Subarachnoid Hemorrhage: A Prospective Observational Study Open
Background Patients with spontaneous subarachnoid hemorrhage (SAH) frequently encounter cognitive dysfunction and mental health issues with negative effects on health-related quality of life (HR-QoL). Here, we aimed to describe the prevale…
View article: Distinct smell and taste disorder phenotype of post-acute COVID-19 sequelae
Distinct smell and taste disorder phenotype of post-acute COVID-19 sequelae Open
View article: Blood Pressure Changes in Association with Nimodipine Therapy in Patients with Spontaneous Subarachnoid Hemorrhage
Blood Pressure Changes in Association with Nimodipine Therapy in Patients with Spontaneous Subarachnoid Hemorrhage Open
View article: The Loss of Temporal Muscle Volume is Associated with Poor Outcome in Patients with Subarachnoid Hemorrhage: An Observational Cohort Study
The Loss of Temporal Muscle Volume is Associated with Poor Outcome in Patients with Subarachnoid Hemorrhage: An Observational Cohort Study Open
Background Intensive care unit (ICU) acquired weakness is a major contributor to poor functional outcome of ICU patients. Quantification of temporal muscle volume assessed on routine computed tomography (CT) scans may serve as a biomarker …
View article: Non-Traumatic Subarachnoid Hemorrhage-Related Acute Hydrocephalus Requiring External Ventricular Drain Placement: Association with Hospital Complications and Functional Outcome
Non-Traumatic Subarachnoid Hemorrhage-Related Acute Hydrocephalus Requiring External Ventricular Drain Placement: Association with Hospital Complications and Functional Outcome Open
View article: Brain microdialysate tau dynamics predict functional and neurocognitive recovery after poor-grade subarachnoid haemorrhage
Brain microdialysate tau dynamics predict functional and neurocognitive recovery after poor-grade subarachnoid haemorrhage Open
Subarachnoid haemorrhage is a devastating disease that results in neurocognitive deficits and a poor functional outcome in a considerable proportion of patients. In this study, we investigated the prognostic value of microtubule-associated…
View article: The location of intraparenchymal bleeding determines functional outcome after spontaneous subarachnoid hemorrhage
The location of intraparenchymal bleeding determines functional outcome after spontaneous subarachnoid hemorrhage Open
Background and purpose Non‐traumatic subarachnoid hemorrhage (SAH) is a devastating disease associated with high morbidity and mortality. A higher blood burden and the presence of intraparenchymal extension of the bleeding (intracerebral h…
View article: Cognitive dysfunction 1 year after <scp>COVID</scp>‐19: evidence from eye tracking
Cognitive dysfunction 1 year after <span>COVID</span>‐19: evidence from eye tracking Open
Increasing evidence suggests persistent cognitive dysfunction after COVID‐19. In this cross‐sectional study, frontal lobe function was assessed 12 months after the acute phase of the disease, using tailored eye tracking assessments. Indivi…
View article: Long-Term Clinical Trajectory of Patients with Subarachnoid Hemorrhage: Linking Acute Care and Neurorehabilitation
Long-Term Clinical Trajectory of Patients with Subarachnoid Hemorrhage: Linking Acute Care and Neurorehabilitation Open
View article: Distinct smell and taste disorder phenotype of post-acute COVID-19 sequelae
Distinct smell and taste disorder phenotype of post-acute COVID-19 sequelae Open
Background Olfactory dysfunction (OD) often accompanies acute coronavirus disease 2019 (COVID-19) and its sequelae. Herein, we investigated OD during COVID-19 recovery in the context of other symptoms, quality of life, physical and mental …
View article: Early supplemental parenteral nutrition for the achievement of nutritional goals in subarachnoid hemorrhage patients: An observational cohort study
Early supplemental parenteral nutrition for the achievement of nutritional goals in subarachnoid hemorrhage patients: An observational cohort study Open
Purpose Enteral nutrition (EN) often fails to achieve nutritional goals in neurocritical care patients. We sought to investigate the safety and utility of supplemental parenteral nutrition (PN) in subarachnoid hemorrhage (SAH) patients. Ma…
View article: Neurological outcomes 1 year after COVID‐19 diagnosis: A prospective longitudinal cohort study
Neurological outcomes 1 year after COVID‐19 diagnosis: A prospective longitudinal cohort study Open
Background and purpose Neurological sequelae from coronavirus disease 2019 (COVID‐19) may persist after recovery from acute infection. Here, the aim was to describe the natural history of neurological manifestations over 1 year after COVID…
View article: The effect of the volemic and cardiac status on brain oxygenation in patients with subarachnoid hemorrhage: a bi-center cohort study
The effect of the volemic and cardiac status on brain oxygenation in patients with subarachnoid hemorrhage: a bi-center cohort study Open
View article: Factors associated with impaired quality of life three months after being diagnosed with COVID-19
Factors associated with impaired quality of life three months after being diagnosed with COVID-19 Open
View article: Intracerebral Iron Accumulation may be Associated with Secondary Brain Injury in Patients with Poor Grade Subarachnoid Hemorrhage
Intracerebral Iron Accumulation may be Associated with Secondary Brain Injury in Patients with Poor Grade Subarachnoid Hemorrhage Open
View article: Hyperactive delirium in patients after non-traumatic subarachnoid hemorrhage
Hyperactive delirium in patients after non-traumatic subarachnoid hemorrhage Open
Our data indicate that hyperactive delirium is common after SAH patients and requires a certain degree of brain connectivity based ono the highest prevalence found in SAH patients with intermediate outcomes.
View article: Neurological outcome and quality of life 3 months after COVID‐19: A prospective observational cohort study
Neurological outcome and quality of life 3 months after COVID‐19: A prospective observational cohort study Open
Background and purpose To assess neurological manifestations and health‐related quality of life (QoL) 3 months after COVID‐19. Methods In this prospective, multicenter, observational cohort study we systematically evaluated neurological si…
View article: The Effect of Temperature Increases on Brain Tissue Oxygen Tension in Patients with Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Substudy
The Effect of Temperature Increases on Brain Tissue Oxygen Tension in Patients with Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Substudy Open
Fever may aggravate secondary brain injury after traumatic brain injury (TBI). The aim of this study was to identify episodes of temperature increases through visual plot analysis and algorithm supported detection, and to describe associat…
View article: Early alterations in heart rate are associated with poor outcome in patients with intracerebral hemorrhage
Early alterations in heart rate are associated with poor outcome in patients with intracerebral hemorrhage Open
The study suggests that a higher variation in heart rate in the early phase after ICH may discriminate patients with poor outcome.
View article: Variability in Serum Sodium Concentration and Prognostic Significance in Severe Traumatic Brain Injury: A Multicenter Observational Study
Variability in Serum Sodium Concentration and Prognostic Significance in Severe Traumatic Brain Injury: A Multicenter Observational Study Open
View article: The Importance of PbtO2 Probe Location for Data Interpretation in Patients with Intracerebral Hemorrhage
The Importance of PbtO2 Probe Location for Data Interpretation in Patients with Intracerebral Hemorrhage Open
View article: Hemodynamic response during endotracheal suctioning predicts awakening and functional outcome in subarachnoid hemorrhage patients
Hemodynamic response during endotracheal suctioning predicts awakening and functional outcome in subarachnoid hemorrhage patients Open
View article: Brain Exposure to Piperacillin in Acute Hemorrhagic Stroke Patients Assessed by Cerebral Microdialysis and Population Pharmacokinetics
Brain Exposure to Piperacillin in Acute Hemorrhagic Stroke Patients Assessed by Cerebral Microdialysis and Population Pharmacokinetics Open
Limited CNS exposure of piperacillin might be an obstacle in treating patients without general meningeal inflammation except for infections with highly susceptible pathogens. Brain exposure of piperacillin did not improve significantly wit…
View article: Brain temperature regulation in poor-grade subarachnoid hemorrhage patients – A multimodal neuromonitoring study
Brain temperature regulation in poor-grade subarachnoid hemorrhage patients – A multimodal neuromonitoring study Open
Elevated body temperature (T core ) is associated with poor outcome after subarachnoid hemorrhage (SAH). Brain temperature (T brain ) is usually higher than T core . However, the implication of this difference (T delta ) remains unclear. W…
View article: Neurological Outcome and Quality of Life Three Months after COVID-19: A Prospective Observational Cohort Study
Neurological Outcome and Quality of Life Three Months after COVID-19: A Prospective Observational Cohort Study Open
View article: Risk Factors for Dysphagia and the Impact on Outcome After Spontaneous Subarachnoid Hemorrhage
Risk Factors for Dysphagia and the Impact on Outcome After Spontaneous Subarachnoid Hemorrhage Open
View article: A Young Woman Presenting with Encephalopathy: A Case Report
A Young Woman Presenting with Encephalopathy: A Case Report Open
View article: Early Predictors for Infectious Complications in Patients With Spontaneous Intracerebral Hemorrhage and Their Impact on Outcome
Early Predictors for Infectious Complications in Patients With Spontaneous Intracerebral Hemorrhage and Their Impact on Outcome Open
Background: Infectious complications (IC) commonly occur in patients with intracerebral hemorrhage (ICH) and are associated with increased length of hospitalization (LOS) and poor long-term outcome. Little is known about early ICH-r…
View article: Subarachnoid Hemorrhage is Followed by Pituitary Gland Volume Loss: A Volumetric MRI Observational Study
Subarachnoid Hemorrhage is Followed by Pituitary Gland Volume Loss: A Volumetric MRI Observational Study Open