Explanipedia

Hemodynamic Heterogeneity in Community-Acquired Sepsis at Intermediate Care Admission: A Prospective Pilot Study Using Impedance Cardiography Open

Gianni Turcato, Arian Zaboli, Lucia Filippi, Fabrizio Lucente, Mario Maggi , et al. · 2025

Background: Sepsis is a heterogeneous syndrome in which patients with similar clinical presentations at admission may exhibit markedly different treatment responses and outcomes, suggesting that comparable macroscopic features can conceal …

Correction: Presurgical Succinate MetAstatic Risk Tool (P-SMART) in Paragangliomas Open

Elena Rapizzi, Lorenzo Zanatta, Alice Santi, Fabio Staderini, Niccolò Galeotti , et al. · 2025

MON-505 Genetic Dissection by Whole Exome Analysis of Unilateral Coexisting Adrenal Cortical Adenoma and Carcinoma in the Context of MEN1 Syndrome Open

Francesca Cioppi, Tommaso Orioli, Giulia Cantini, Tonino Ercolino, Federica Cioppi , et al. · 2025

Disclosure: F. Cioppi: None. T. Orioli: None. G. Cantini: None. T. Ercolino: None. F. Cioppi: None. G. Assié: None. A. Jouinot: None. A.A. Dedonno: None. M. Maggi: None. M. Benelli: None. L. Canu: None. G. Nesi: None. M. Luconi: None. Mult…

Presurgical Succinate MetAstatic Risk Tool (P-SMART) in Paragangliomas Open

Elena Rapizzi, Lorenzo Zanatta, Alice Santi, Fabio Staderini, Niccolò Galeotti , et al. · 2025

Temporal Decline in Intravascular Albumin Mass and Its Association with Fluid Balance and Mortality in Sepsis: A Prospective Observational Study Open

Christian J. Wiedermann, Arian Zaboli, Fabrizio Lucente, Lucia Filippi, Mario Maggi , et al. · 2025

Background: Intravascular albumin mass represents the total quantity of albumin circulating within the bloodstream and may serve as a physiologically relevant marker of vascular integrity and fluid distribution in sepsis. While low serum a…

The role of an intermediate care unit in reducing intensive care unit admissions and improving patient outcomes in internal medicine: A quasi-experimental study Open

Gianni Turcato, Arian Zaboli, Paolo Ferretto, Lucia Filippi, Daniela Milazzo , et al. · 2025

Endothelial Damage in Sepsis: The Interplay of Coagulopathy, Capillary Leak, and Vasoplegia—A Physiopathological Study Open

Gianni Turcato, Arian Zaboli, Lucia Filippi, Alessandro Cipriano, Paolo Ferretto , et al. · 2025

Background: Sepsis remains a leading cause of mortality worldwide, and understanding endothelial damage is crucial for improving patient outcomes. Endothelial dysfunction in sepsis contributes to coagulopathy, increased capillary permeabil…

Sepsis-Induced Coagulopathy and Hypoalbuminemia: Endothelial Damage as Common Pathway and Clinical Implications on Mortality and Transfusion Risk Open

Gianni Turcato, Arian Zaboli, Fabrizio Lucente, Lucia Filippi, Mario Maggi , et al. · 2025

Background: Sepsis-induced coagulopathy (SIC) and hypoalbuminemia represent distinct yet interrelated manifestations of endothelial dysfunction in sepsis. While both have been individually associated with increased mortality, their combine…

The hormonal regulation of men’s sexual desire, arousal, and penile erection: recommendations from the fifth international consultation on sexual medicine (ICSM 2024) Open

Giulia Rastrelli, Leen Antonio, Serge Carrier, Andrea M. Isidori, Mario Maggi · 2025

Introduction The sexual response, including sexual desire and arousal/penile erection in men, is affected by several hormones and neurotransmitters. Objectives To give resources to understand the usefulness to assess different hormones whe…

Use and utility of endocrine multidisciplinary tumour board: an appraisal from a tertiary centre Open

Clotilde Sparano, Letizia Canu, Giuliano Perigli, Roberto Santoro, Silvia Pradella , et al. · 2025

Introduction The Endocrine Multidisciplinary Tumour Board (EMTB) is a specialised board for endocrine tumours, including thyroid, adrenal, and rare endocrine neoplasms. Although required by major guidelines, little is known about the curre…

AGE DISPARITY IN COUPLES AND THE SEXUAL AND GENERAL HEALTH OF THE MALE PARTNER Open

Clotilde Sparano, Daniele Vignoli, Giulia Rastrelli, Linda Vignozzi, Giovanni Corona , et al. · 2025

Objectives Several robust epidemiological studies conducted in different cultures suggest that men are often engaged in sexual relationships with younger women with a variable, age-dependent age difference. However, the ageing process dete…

IMPACT OF BETA-BLOCKERS ON ERECTILE FUNCTION: A META-ANALYSIS Open

Walter Vena, Giovanni Corona, Alessandro Pizzocaro, Gianmaria Salvio, Clotilde Sparano , et al. · 2025

Objectives Although the use of beta-blockers (BBs) has been associated with worse erectile function, their real contribution is still conflicting. To better clarify their role on erectile dysfunction (ED), we systematically investigated da…

IS “LIVING APART TOGETHER” (LAT) A REAL ADVANTAGE FOR SUBJECTS PRESENTING SEXUAL DYSFUNCTION? A COHORT STUDY Open

Clotilde Sparano, Giovanni Corona, G Rastrelli, L Vignozzi, Daniele Vignoli , et al. · 2025

Objectives Quantitative research on families and couples has introduced a new relationship category, known as LAT (Living Apart Together) relationships. This study aims to verify whether or not LAT is improving sexual relationships in thos…

ROLE OF AROMATASE INHIBITORS ON SEXUAL DESIRE IN MEN: A SYSTEMATIC REVIEW AND META-ANALYSIS Open

Giovanni Corona, G Rastrelli, Clotilde Sparano, Linda Vignozzi, Alessandra Sforza , et al. · 2025

Objectives Considering that the use of aromatase inhibitors (AIs) has been associated with an increase in hypothalamus pituitary testis axis (HPT) activity these medications were also tried for the treatment of male hypogonadism. However, …

AN ELEVATED GLYCOSYLATED HAEMOGLOBIN LEVEL IS ASSOCIATED WITH A HIGHER RISK OF PENILE PROSTHESIS INFECTION: SYSTEMATIC REVIEW AND META-ANALYSIS Open

W G Lee, Paolo Capogrosso, Damirbek Osmonov, Koenraad van Renterghem, Javier Otero , et al. · 2025

Objectives The impact of preoperative glycometabolic profile of diabetic patients on the risk of penile prosthesis (PP) infection remains uncertain. Current data are conflicting but the studies to date have been limited by retrospective de…

PSYCHOSEXUAL CHARACTERISTICS OF THE WOMEN REFERRING THE “SQUIRTING” PHENOMENON Open

Elisa Maseroli, Francesco Pesce, Elena Colonnello, Sarah Cipriani, Andrea Sansone , et al. · 2025

Objectives Women can produce a wide range of secretions during arousal and with orgasm. In particular, squirting (Sq) and ejaculation (FE) are, respectively, the copious or scarce expulsions of fluids during stimulation of the clitoral-ure…

CARDIOVASCULAR SAFETY OF TESTOSTERONE REPLACEMENT THERAPY IN MEN: AN UPDATED SYSTEMATIC REVIEW AND META- ANALYSIS Open

Giovanni Corona, Giulia Rastrelli, Clotilde Sparano, Valeria Carinci, Gianni Casella , et al. · 2025

Objectives The cardiovascular (CV) safety of testosterone (T) replacement therapy (TRT) is still conflicting. Recent data suggested a TRT-related increased risk of atrial fibrillation (AF). To systematic review and meta-analyze CV risk rel…

NUTRACEUTICAL INTERVENTIONS FOR ERECTILE DYSFUNCTION: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS Open

L Spagnolo, Daniele Tienforti, Maria Totaro, Mario Maggi, Giovanni Corona , et al. · 2025

Objectives Although nutraceutical-based treatments are often provided for erectile dysfunction (ED), their efficacy remains doubtful, and the choice of one preparation over the other is challenged by the dearth of head-to-head comparative …

IMPACT OF DIABETIC MEDICATIONS ON ERECTILE FUNCTION: A META-ANALYSIS Open

G Rastrelli, Giovanni Corona, Clotilde Sparano, L Vignozzi, Alessandra Sforza , et al. · 2025

Objectives Erectile dysfunction (ED) is a neglected complication of patients with pre-diabetes or diabetes mellitus (DM). In addition, the impact of the different diabetic medication has been poorly investigated. Methods A comprehensive sy…

(172) PSYCHOSEXUAL CHARACTERISTICS OF WOMEN REFERRING THE “SQUIRTING” PHENOMENON Open

Elisa Maseroli, Serena Anna Ravelli, Francesco Pesce, Elena Colonnello, Sarah Cipriani , et al. · 2025

Introduction Women can produce a wide range of secretions during arousal and with orgasm. In particular, squirting (Sq) and ejaculation (FE) are, respectively, the copious or scarce expulsions of fluids during stimulation of the clitoral-u…

Is ‘living apart together’ a real advantage for patients consulting for sexual dysfunction? A cohort study Open

Clotilde Sparano, Giovanni Corona, Giulia Rastrelli, Linda Vignozzi, Daniele Vignoli , et al. · 2025

Background Quantitative research on families has introduced a new category of relationship called living apart together, that is, when a couple in a committed relationship live in separate homes. This study aimed to confirm whether living …

Pros and cons of surgical versus conservative management for head and neck paraganglioma: a real-world data analysis Open

Letizia Canu, L. Zanatta, Clotilde Sparano, Roberto Santoro, Giuditta Mannelli , et al. · 2025

Nutraceutical interventions for erectile dysfunction: a systematic review and network meta-analysis Open

Arcangelo Barbonetti, Daniele Tienforti, Federica Antolini, Luca Spagnolo, Francesca Cavallo , et al. · 2024

Background Although nutraceutical-based treatments are often offered for erectile dysfunction (ED), their efficacy remains doubtful, and the choice of one substance over the other is challenged by the dearth of head-to-head comparative stu…

Anti-hypertensive medications and erectile dysfunction: focus on β-blockers Open

Giovanni Corona, Walter Vena, Alessandro Pizzocaro, Gianmaria Salvio, Clotilde Sparano , et al. · 2024

Purpose Although anti-hypertensive medications, including thiazides and β-blockers (BBs) in particular, have been suggested to cause erectile dysfunction (ED) their real contribution is still conflicting. The aim of this paper is to summar…

Weight Loss as Therapeutic Option to Restore Fertility in Obese Men: A Meta-Analytic Study Open

Daniele Santi, Carla Greco, Arcangelo Barbonetti, Manuela Simoni, Mario Maggi , et al. · 2024

This meta-analytic analysis confirmed that body weight loss may improve qualitative and quantitative sperm characteristics providing evidence for suggesting weight loss to male partners with obesity and semen analysis alteration in couples…

Hypoactive sexual desire disorder in women: new possibilities to ensure better understanding, diagnosis, and response to treatment Open

Elisa Maseroli, Sarah Cipriani, Valeria Lanzi, Serena Anna Ravelli, Mattia Annunziato , et al. · 2024

Background Hypoactive Sexual Desire Disorder (HSDD) is a frequent sex-related problem in women; however, a specific tool to characterize HSDD subtypes based on sexual inhibitory and excitatory factors is still lacking. Aim (1) To find a cu…

Age disparity in couples and the sexual and general health of the male partner Open

Clotilde Sparano, Giulia Rastrelli, Giovanni Corona, Linda Vignozzi, Daniele Vignoli , et al. · 2024

Introduction Several robust epidemiological studies suggest that men are often engaged in sexual relationships with younger women with a variable, age‐dependent age difference. However, the ageing process determines a significant worsening…

The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis Open

Paolo Comeglio, Giulia Guarnieri, Sandra Filippi, Ilaria Cellai, Gabriele Acciai , et al. · 2024

Introduction Galectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhib…

Acquired hypoprolactinemia in men, possible phenotype Open

Giovanni Corona, Giulia Rastrelli, Clotilde Sparano, Linda Vignozzi, Mario Maggi · 2024

The physiological role of prolactin (PRL) in men is still not well defined. The pathological increase is characterized by sexual function impairment along with possible negative consequences in body composition and metabolic profile. Conve…

Long‐term penile prosthesis couple's satisfaction: A systematic review and meta‐analysis Open

Giovanni Corona, Daniele Santi, Andrea Cocci, Walter Vena, Alessandro Pizzocaro , et al. · 2024

Context Data supporting successful and satisfactory penile prosthesis (PP) implantation outcomes are mainly based on subjective, rather than objective, analysis. Objective To systematically review and objectively analyze, all available dat…

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