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View article: Investigating the causal pathways among psychopathological variables, cognitive impairment, and real-life functioning in people with schizophrenia
Investigating the causal pathways among psychopathological variables, cognitive impairment, and real-life functioning in people with schizophrenia Open
Introduction The present study aimed to investigate the causal relationships among cognitive impairment, psychopathology, and real-life functioning in a large sample of people with schizophrenia, using a data-driven causal discovery proced…
View article: Genome-wide association studies of binge-eating behaviour and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes
Genome-wide association studies of binge-eating behaviour and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes Open
Eating disorders—including anorexia nervosa (AN), bulimia nervosa, and binge eating disorder—are clinically distinct but exhibit symptom overlap and diagnostic crossover. Genomic analyses have mostly examined AN. We conducted the first gen…
View article: The lived experience of postpartum depression and psychosis in women: a bottom‐up review co‐written by experts by experience and academics
The lived experience of postpartum depression and psychosis in women: a bottom‐up review co‐written by experts by experience and academics Open
This is the first bottom‐up review of the lived experience of postpartum depression and psychosis in women. The study has been co‐designed, co‐conducted and co‐written by experts by experience and academics, drawing on first‐person account…
View article: The lived experience of mental disorders in adolescents: a bottom‐up review co‐designed, co‐conducted and co‐written by experts by experience and academics
The lived experience of mental disorders in adolescents: a bottom‐up review co‐designed, co‐conducted and co‐written by experts by experience and academics Open
We provide here the first bottom‐up review of the lived experience of mental disorders in adolescents co‐designed, co‐conducted and co‐written by experts by experience and academics. We screened first‐person accounts within and outside the…
View article: Philosophy of psychiatry: theoretical advances and clinical implications
Philosophy of psychiatry: theoretical advances and clinical implications Open
Work at the intersection of philosophy and psychiatry has an extensive and influential history, and has received increased attention recently, with the emergence of professional associations and a growing literature. In this paper, we revi…
View article: Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study
Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study Open
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bi…
View article: The relationship between obsessive–compulsive symptoms and real-life functioning in schizophrenia: New insights from the multicenter study of the Italian Network for Research on Psychoses
The relationship between obsessive–compulsive symptoms and real-life functioning in schizophrenia: New insights from the multicenter study of the Italian Network for Research on Psychoses Open
Background Although obsessive–compulsive disorder (OCD) is highly prevalent in schizophrenia, its relationship with patients’ real-life functioning is still controversial. Methods The present study aims at investigating the prevalence of O…
View article: Research evidence on the management of the cognitive impairment component of the post-COVID condition: a qualitative systematic review
Research evidence on the management of the cognitive impairment component of the post-COVID condition: a qualitative systematic review Open
Background Cognitive impairment (CI) is one of the most prevalent and burdensome consequences of COVID-19 infection, which can persist up to months or even years after remission of the infection. Current guidelines on post-COVID CI are bas…
View article: GENERATIVE AI ROLE IN BUILDING 3PL COMPANIES’ RESILIENCE
GENERATIVE AI ROLE IN BUILDING 3PL COMPANIES’ RESILIENCE Open
Purpose: The purpose of this study is to evaluate the impact of generative artificial intelligence (gen-AI) models on the operational resilience of third-party logistics (3PL) companies. The research explores how gen-AI supports 3PL compan…
View article: External validation of the five domains of negative symptoms: Focus on cognition, functional capacity, and real-world functioning
External validation of the five domains of negative symptoms: Focus on cognition, functional capacity, and real-world functioning Open
Background The conceptualization of negative symptoms (NS) in schizophrenia is still controversial. Recent confirmatory factor-analytic studies suggested that the bi-dimensional model (motivational deficit [MAP] and expressive deficit [EXP…
View article: Cognitive impairment after recovery from COVID-19: Frequency, profile, and relationships with clinical and laboratory indices
Cognitive impairment after recovery from COVID-19: Frequency, profile, and relationships with clinical and laboratory indices Open
Cognitive impairment (CI) is regarded as a remarkable burden in COVID-19 survivors. Its prevalence and profile, and relationships with the disease clinical and laboratory indices, remain unclear. The present study investigated, in a large …
View article: Exploring the genetics of lithium response in bipolar disorders
Exploring the genetics of lithium response in bipolar disorders Open
Background: Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has been shown to have be…
View article: Autistic symptoms in unaffected first-degree relatives of people with schizophrenia: results from the Italian Network for Research on Psychoses multicenter study
Autistic symptoms in unaffected first-degree relatives of people with schizophrenia: results from the Italian Network for Research on Psychoses multicenter study Open
A high prevalence of autistic symptoms was observed in first-degree relatives of people with SSD. Autistic symptoms severity showed a negative correlation with cognitive performance and functional outcomes also in this population and may r…
View article: The lived experience of depression: a bottom‐up review co‐written by experts by experience and academics
The lived experience of depression: a bottom‐up review co‐written by experts by experience and academics Open
We provide here the first bottom‐up review of the lived experience of depression, co‐written by experts by experience and academics. First‐person accounts within and outside the medical field were screened and discussed in collaborative wo…
View article: Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions
Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions Open
Treatment‐resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD with demonstrated predictive utility in terms of clinical decision‐making and health outcomes doe…
View article: Understanding depression beyond the “mind‐body” dichotomy
Understanding depression beyond the “mind‐body” dichotomy Open
In both the ICD-11 and the DSM-5, the core symptoms of depression are reported to be depressed mood (e.g., feeling sad, down or hopeless) and markedly diminished interest or pleasure in activities. However, in the ICD-10 diagnostic guideli…
View article: The structure stability of negative symptoms: longitudinal network analysis of the Brief Negative Symptom Scale in people with schizophrenia
The structure stability of negative symptoms: longitudinal network analysis of the Brief Negative Symptom Scale in people with schizophrenia Open
Background The structure of negative symptoms of schizophrenia is still a matter of controversy. Although a two-dimensional model (comprising the expressive deficit dimension and the motivation and pleasure dimension) has gained a large co…
View article: Autistic and Catatonic Spectrum Symptoms in Patients with Borderline Personality Disorder
Autistic and Catatonic Spectrum Symptoms in Patients with Borderline Personality Disorder Open
Background: Recent literature has shown that a considerable percentage of patients with severe mental disorders can develop, over time, full-blown or subthreshold catatonia. Some studies corroborate the model of an illness trajectory in wh…
View article: The mediating effect of mood spectrum on the relationship between autistic traits and catatonia spectrum
The mediating effect of mood spectrum on the relationship between autistic traits and catatonia spectrum Open
Background In the recent years, several studies have shown a correlation between autism spectrum disorder (ASD) and catatonia. It is also known that both conditions are found to be associated with mood disorders. This study aimed to invest…
View article: Investigating suicidality across the autistic-catatonic continuum in a clinical sample of subjects with major depressive disorder and borderline personality disorder
Investigating suicidality across the autistic-catatonic continuum in a clinical sample of subjects with major depressive disorder and borderline personality disorder Open
Background Recent literature has highlighted that catatonia may be more prevalent among psychiatric patients than previously thought, beginning from autism spectrum disorders (ASD), for which it has been suggested to represent a severe lat…
View article: The structure stability of negative symptoms: longitudinal network analysis of the Brief Negative Symptom Scale in subjects with schizophrenia
The structure stability of negative symptoms: longitudinal network analysis of the Brief Negative Symptom Scale in subjects with schizophrenia Open
Introduction Negative symptoms (NS) represent an unmet need of treatment in schizophrenia (SCZ). As a result, these symptoms pose a significant burden on patients, their families, and the health care system. In the last decade, the concept…
View article: Resting-state brain activity dysfunctions in schizophrenia and their associations with negative symptom domains
Resting-state brain activity dysfunctions in schizophrenia and their associations with negative symptom domains Open
Introduction Negative symptoms represent a fundamental aspect of schizophrenia: they have a substantial impact on patients’ real-life functioning and do not respond satisfactorily to currently available treatments. Therefore, a better unde…