Mario Maresca
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View article: Effects of Cadmium on ZO-1 Tight Junction Integrity of the Blood Brain Barrier
Effects of Cadmium on ZO-1 Tight Junction Integrity of the Blood Brain Barrier Open
Cadmium (Cd) is a highly toxic environmental pollutant released from the smelting and refining of metals and cigarette smoking. Oral exposure to cadmium may result in adverse effects on a number of tissues, including the central nervous sy…
View article: Oxaliplatin-induced blood brain barrier loosening: a new point of view on chemotherapy-induced neurotoxicity
Oxaliplatin-induced blood brain barrier loosening: a new point of view on chemotherapy-induced neurotoxicity Open
Oxaliplatin is a key drug in the treatment of advanced metastatic colorectal cancer. Despite its beneficial effects in tumor reduction, the most prevalent side-effect of oxaliplatin treatment is a chemotherapy-induced neuropathy that frequ…
View article: The pathophysiological role of the blood brain barrier in the oxaliplatin-induced neuropathy
The pathophysiological role of the blood brain barrier in the oxaliplatin-induced neuropathy Open
Oxaliplatin has become part of the world-wide standard of care for the
\nadjuvant and the palliative treatment of the metastatic colon cancer. However,
\nits efficacy is hampered by dose-limiting neurotoxicity, which leads to painful
\nsen…
View article: Cadmium-induced neurotoxicity: impairment of the blood brain barrier
Cadmium-induced neurotoxicity: impairment of the blood brain barrier Open
Cadmium (Cd), an ubiquitous heavy metal, known to be accumulated outside of the blood–brain barrier (1) and to cause neurotoxicity, has also been demonstrated to induce an increase in the blood–brain barrier (BBB) permeability (2). Key com…
View article: Protective effect of selenium and zinc against cadmium toxicity in SHSY-5Y neurons
Protective effect of selenium and zinc against cadmium toxicity in SHSY-5Y neurons Open
Cadmium is a widespread heavy metal environmental toxicant and pollutant. Cadmium toxicity affects many tissues and organs including the central nervous system and cadmium exposure has been related to many neurodegenerative diseases (1). C…
View article: Zinc protection in cadmium-induced Blood Brain Barrier permeability: a metabolic and morphological in vitro study
Zinc protection in cadmium-induced Blood Brain Barrier permeability: a metabolic and morphological in vitro study Open
Cadmium (Cd) is a worldwide occupational and environmental pollutant [1]. Cd toxicity is widely known and studied in many tissues and organs such as testis, kidney, liver, lung and brain [2,3]. On the other hand, zinc (Zn) is a trace eleme…
View article: Effects of the endoplasmic reticulum signaling pathway on cadmium-induced impairment of the blood brain barrier
Effects of the endoplasmic reticulum signaling pathway on cadmium-induced impairment of the blood brain barrier Open
Due to its high permeability to blood-brain barrier (BBB), cadmium (Cd) has been regarded as a possible etiological factor for human neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease [1]…
View article: Effects of a water extract of <i>Lepidium meyenii</i> root in different models of persistent pain in rats
Effects of a water extract of <i>Lepidium meyenii</i> root in different models of persistent pain in rats Open
Lepidium meyenii (Walp.), commonly called maca, is an Andean crop belonging to the Brassicaceae family. Maca hypocotils are habitually consumed as customary food as well as traditional remedies for pathological conditions such as infertili…
View article: Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis
Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis Open
The NE inhibitor EL-17 relieved articular pain after acute administration. Furthermore, repeated treatment reduced the development of hypersensitivity and protected joint tissue, revealing a disease-modifying profile.