Mario Mitt
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New evidence of genetic adaptation to high altitude in Andean populations Open
Background: High altitude is characterised by hypoxia, arid climate, high solar radiation and other environmental stressors. Andeans have resided at high elevations for several millennia and have developed an unique array of physiological …
Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel Open
Genetic imputation is a cost-efficient way to improve the power and resolution of genome-wide association (GWA) studies. Current publicly accessible imputation reference panels accurately predict genotypes for common variants with minor al…
Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel Open
Genetic imputation is a cost-efficient way to improve the power and resolution of genome-wide association (GWA) studies. Current publicly accessible imputation reference panels accurately predict genotypes for common variants with minor al…
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms Open
Significance Human blood cell production is coordinated to ensure balanced levels of all lineages. The basis of this regulation remains poorly understood. Identification of genetic differences in human populations associated with blood cel…
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms Open
Genetic variants affecting hematopoiesis can influence commonly measured blood cell traits. To identify factors that affect hematopoiesis, we performed association studies for blood cell traits in the population-based Estonian Biobank usin…
Candidate gene networks and blood biomarkers of methamphetamine-associated psychosis: an integrative RNA-sequencing report Open
The clinical presentation, course and treatment of methamphetamine (METH)-associated psychosis (MAP) are similar to that observed in schizophrenia (SCZ) and subsequently MAP has been hypothesized as a pharmacological and environmental mode…