Mário Sérgio Palma
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View article: Targeted Metabolomics of <i>Tityus</i> Scorpion Venoms: Unveiling Small-Molecule Components
Targeted Metabolomics of <i>Tityus</i> Scorpion Venoms: Unveiling Small-Molecule Components Open
Scorpion venoms consist of proteins, peptides, and various low molecular weight (LMW) organic compounds, which act as toxins. Despite their potential significance, these compounds in scorpion venoms have been little investigated and their …
View article: Tweaking Polybia-MP1: How a Lysine-Histidine Swap Redefines Its Surface Properties
Tweaking Polybia-MP1: How a Lysine-Histidine Swap Redefines Its Surface Properties Open
Background/Objectives: Polybia-MP1 (MP1) exhibits antimicrobial and anticancer properties. To improve selectivity toward acidic tumor microenvironments, we designed HMP1, a histidine-substituted analog of MP1, aiming to introduce pH-respon…
View article: Peptides from <i>Galleria mellonella</i> against <i>Cryptococcus</i> spp: toxicity in three-dimensional cell cultures and <i>G. mellonella</i>
Peptides from <i>Galleria mellonella</i> against <i>Cryptococcus</i> spp: toxicity in three-dimensional cell cultures and <i>G. mellonella</i> Open
Aim: This work aimed to test peptides against the planktonic and biofilm form of Cryptococcus spp. and in vitro toxicity using three-dimensional (3D) cells characterized and evaluate in vivo toxicity in Galle…
View article: The Sall2 transcription factor promotes cell migration regulating focal adhesion turnover and integrin β1 expression
The Sall2 transcription factor promotes cell migration regulating focal adhesion turnover and integrin β1 expression Open
SALL2/Sall2 is a transcription factor associated with development, neuronal differentiation, and cancer. Interestingly, SALL2/Sall2 deficiency leads to failure of the optic fissure closure and neurite outgrowth, suggesting a positive role …
View article: Mastoparans: A Group of Multifunctional α-Helical Peptides With Promising Therapeutic Properties
Mastoparans: A Group of Multifunctional α-Helical Peptides With Promising Therapeutic Properties Open
Biologically active peptides have been attracting increasing attention, whether to improve the understanding of their mechanisms of action or in the search for new therapeutic drugs. Wasp venoms have been explored as a remarkable source fo…
View article: Bioprospecting macroalgae, marine and terrestrial invertebrates & their associated microbiota
Bioprospecting macroalgae, marine and terrestrial invertebrates & their associated microbiota Open
The present review aims the discussion of the impact of the bioprospection initiative developed by the projects associated to BIOprospecTA, a subprogram of the program BIOTA, supported by FAPESP. This review brings a summary of the main re…
View article: The Specific Elongation Factor to Selenocysteine Incorporation in Escherichia coli: Unique tRNASec Recognition and its Interactions
The Specific Elongation Factor to Selenocysteine Incorporation in Escherichia coli: Unique tRNASec Recognition and its Interactions Open
View article: The Antimicrobial Peptide MK58911-NH <sub>2</sub> Acts on Planktonic, Biofilm, and Intramacrophage Cells of Cryptococcus neoformans
The Antimicrobial Peptide MK58911-NH <sub>2</sub> Acts on Planktonic, Biofilm, and Intramacrophage Cells of Cryptococcus neoformans Open
Cryptococcosis is associated with high rates of morbidity and mortality, especially in AIDS patients. Its treatment is carried out by combining amphotericin B and azoles or flucytosine, which causes unavoidable toxicity issues in the host.
View article: Correction to: Salivary glands in workers of Ruptitermes spp. (Blattaria, Isoptera, Termitidae, Apicotermitinae): a morphological and preoteomic approach
Correction to: Salivary glands in workers of Ruptitermes spp. (Blattaria, Isoptera, Termitidae, Apicotermitinae): a morphological and preoteomic approach Open
View article: Salivary glands in workers of Ruptitermes spp. (Blattaria, Isoptera, Termitidae, Apicotermitinae): a morphological and preoteomic approach
Salivary glands in workers of Ruptitermes spp. (Blattaria, Isoptera, Termitidae, Apicotermitinae): a morphological and preoteomic approach Open
View article: The effect of acidic pH on the adsorption and lytic activity of the peptides Polybia-MP1 and its histidine-containing analog in anionic lipid membrane: a biophysical study by molecular dynamics and spectroscopy
The effect of acidic pH on the adsorption and lytic activity of the peptides Polybia-MP1 and its histidine-containing analog in anionic lipid membrane: a biophysical study by molecular dynamics and spectroscopy Open
View article: Modulatory Effects of Acidic pH and Membrane Potential on the Adsorption of pH-Sensitive Peptides to Anionic Lipid Membrane
Modulatory Effects of Acidic pH and Membrane Potential on the Adsorption of pH-Sensitive Peptides to Anionic Lipid Membrane Open
Anionic lipid membrane electrostatic potential and solution pH can influence cationic peptide adsorption to these bilayers, especially those containing simultaneously acid and basic residues. Here, we investigate the effects of the pH solu…
View article: Mapping Biochemical Pathways in Maytenus ilicifolia (Celastraceae) through Integrated Proteomics and Histochemistry
Mapping Biochemical Pathways in Maytenus ilicifolia (Celastraceae) through Integrated Proteomics and Histochemistry Open
Maytenus ilicifolia (Celastraceae) is a medicinal plant that is native to southern Brazil and is popularly known as “espinheira-santa”. From a biosynthesis perspective, this species accumulates quinonemethide triterpenes and sesquiterpene …
View article: The effect of acidic pH on the interaction and lytic activity of MP1 and its H-MP1 analog in anionic lipid membrane: a biophysical study by Molecular Dynamics and Spectroscopy
The effect of acidic pH on the interaction and lytic activity of MP1 and its H-MP1 analog in anionic lipid membrane: a biophysical study by Molecular Dynamics and Spectroscopy Open
Antimicrobial peptides (AMPs) are part of the innate immune system of many species and are compounds with potential application against the development of resistant bacterial strains promoted by conventional antibiotics. The AMPs are rich …
View article: Proteomics: The Science of Functional and Structural Characterization of Proteins
Proteomics: The Science of Functional and Structural Characterization of Proteins Open
View article: In Situ Proteomic Analysis of Glioblastoma Multiforme: A Translational Approach to Improve Prognostic/Diagnostic Routines
In Situ Proteomic Analysis of Glioblastoma Multiforme: A Translational Approach to Improve Prognostic/Diagnostic Routines Open
In order to evaluate the use of matrix-assisted laser desorption ionization (MALDI) Mass Spectral Imaging (MSI) to Glioblastoma (GBM) studies, some sections of formalin fixed paraffin embedded samples of GBM tumors were submitted to classi…
View article: Mapping Biochemical Pathways in Maytenus ilicifolia (Celastraceae) through Integrated Proteomics and Histochemistry
Mapping Biochemical Pathways in Maytenus ilicifolia (Celastraceae) through Integrated Proteomics and Histochemistry Open
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View article: Revealing the Venomous Secrets of the Spider’s Web
Revealing the Venomous Secrets of the Spider’s Web Open
Orb-weaving spiders use a highly strong, sticky and elastic web to catch their prey. These web properties alone would be enough for the entrapment of prey; however, these spiders may be hiding venomous secrets in the web, which current res…
View article: Using a toxicoproteomic approach to investigate the effects of thiamethoxam into the brain of Apis mellifera
Using a toxicoproteomic approach to investigate the effects of thiamethoxam into the brain of Apis mellifera Open
View article: Comparing activity, toxicity and model membrane interactions of Jelleine-I and Trp/Arg analogs: analysis of peptide aggregation
Comparing activity, toxicity and model membrane interactions of Jelleine-I and Trp/Arg analogs: analysis of peptide aggregation Open
View article: Improved production of the recombinant phospholipase A1 from Polybia paulista wasp venom expressed in bacterial cells for use in routine diagnostics
Improved production of the recombinant phospholipase A1 from Polybia paulista wasp venom expressed in bacterial cells for use in routine diagnostics Open
View article: Digestion of Intact Gluten Proteins by <i>Bifidobacterium</i> Species: Reduction of Cytotoxicity and Proinflammatory Responses
Digestion of Intact Gluten Proteins by <i>Bifidobacterium</i> Species: Reduction of Cytotoxicity and Proinflammatory Responses Open
Celiac disease (CD) is a chronic illness characterized by an inflammatory process triggered by gluten protein intake. Recent evidence has suggested that the lower relative abundance of bifidobacteria in the intestinal lumen may be associat…
View article: Current challenges in molecular diagnostics of insect venom allergy
Current challenges in molecular diagnostics of insect venom allergy Open
View article: In Situ Metabolomics of the Honeybee Brain: The Metabolism of <scp>l</scp>-Arginine through the Polyamine Pathway in the Proboscis Extension Response (PER)
In Situ Metabolomics of the Honeybee Brain: The Metabolism of <span>l</span>-Arginine through the Polyamine Pathway in the Proboscis Extension Response (PER) Open
The proboscis extension response (PER) reflex may be used to condition the pairing of an odor with sucrose, which is applied to the antennae, in experiments to induce learning, where the odor represents a conditioned stimulus, while sucros…
View article: Proteomic-components provide insights into the defensive secretion in termite workers of the soldierless genus Ruptitermes
Proteomic-components provide insights into the defensive secretion in termite workers of the soldierless genus Ruptitermes Open
View article: Antifungal Activity, Toxicity, and Membranolytic Action of a Mastoparan Analog Peptide
Antifungal Activity, Toxicity, and Membranolytic Action of a Mastoparan Analog Peptide Open
Invasive fungal infections, such as cryptococcosis and paracoccidioidomycosis are associated with significant rates of morbidity and mortality. Cryptococcosis, caused by Cryptococcus neoformans, is distributed worldwide and has rece…
View article: Worker Defensive Behavior Associated with Toxins in the Neotropical Termite Neocapritermes braziliensis (Blattaria, Isoptera, Termitidae, Termitinae)
Worker Defensive Behavior Associated with Toxins in the Neotropical Termite Neocapritermes braziliensis (Blattaria, Isoptera, Termitidae, Termitinae) Open
View article: Revisiting Polybia paulista wasp venom using shotgun proteomics – Insights into the N-linked glycosylated venom proteins
Revisiting Polybia paulista wasp venom using shotgun proteomics – Insights into the N-linked glycosylated venom proteins Open
View article: Insect venom phospholipases A1 and A2: Roles in the envenoming process and allergy
Insect venom phospholipases A1 and A2: Roles in the envenoming process and allergy Open
View article: Spider silk proteome provides insight into the structural characterization of Nephila clavipes flagelliform spidroin
Spider silk proteome provides insight into the structural characterization of Nephila clavipes flagelliform spidroin Open
The capture spiral of web from N. clavipes spider consists of a single type of spidroin - the flagelliform silk protein, a natural material representing a combination of strength and high elasticity. Flagelliform spider silk is the most ex…