Mario Siervo
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View article: Dietary patterns and endothelium dysfunction: a literature review
Dietary patterns and endothelium dysfunction: a literature review Open
View article: Sarcopenic obesity prevalence and clinical implications in patients with advanced knee osteoarthritis and class II-III obesity
Sarcopenic obesity prevalence and clinical implications in patients with advanced knee osteoarthritis and class II-III obesity Open
SO was present in 28% (95%CI 15.5-40.4) of our sample with knee OA, with clinically unfavourable implications on measured and self-reported physical function and quality of life. Identification of SO may better stratify patients and enable…
View article: Comparing body composition techniques against an adapted multicompartment model in individuals with excess body weight
Comparing body composition techniques against an adapted multicompartment model in individuals with excess body weight Open
View article: LIFE’s essential 8: a roadmap for preventing cardiometabolic disease progression
LIFE’s essential 8: a roadmap for preventing cardiometabolic disease progression Open
View article: Improving Muscle Function Through a Multimodal Behavioural Intervention for Knee Osteoarthritis and Obesity: The POMELO Trial
Improving Muscle Function Through a Multimodal Behavioural Intervention for Knee Osteoarthritis and Obesity: The POMELO Trial Open
Background Treatments aimed at improving physical function and body composition, including reducing fat mass (FM) and increasing muscle mass, may benefit individuals with advanced knee osteoarthritis (OA) and obesity. We investigated the f…
View article: Consensus statement on exploring the Nexus between nutrition, brain health and dementia prevention
Consensus statement on exploring the Nexus between nutrition, brain health and dementia prevention Open
View article: Methodological standards for body composition—an expert-endorsed guide for research and clinical applications: levels, models, and terminology
Methodological standards for body composition—an expert-endorsed guide for research and clinical applications: levels, models, and terminology Open
Body composition assessment is widely used in both research and clinical practice, yet confusion over basic concepts and terminology persists, leading to inaccurate assessments, comparisons, and interpretations. To address this concern, an…
View article: Inorganic nitrate stores, astrocyte metabolism and brain health: An emerging paradigm
Inorganic nitrate stores, astrocyte metabolism and brain health: An emerging paradigm Open
Inorganic nitrate plays a crucial role in the regulation of cerebral blood flow and neurotransmission through its conversion to nitric oxide (NO). Astrocytes are star-shaped glial cells and contribute to maintain the blood-brain barrier in…
View article: Temporal dynamics in the association between depression and dementia: an umbrella review and meta-analysis
Temporal dynamics in the association between depression and dementia: an umbrella review and meta-analysis Open
View article: Healthy dietary patterns, cognition and dementia risk: current evidence and context
Healthy dietary patterns, cognition and dementia risk: current evidence and context Open
Approximately 60 million individuals worldwide are currently living with dementia. As the median age of the world’s population rises, the number of dementia cases is expected to increase markedly, and to affect ∼150 million individuals by …
View article: Metabolic profile of healthy, normal-weight adults with low satiety responsiveness
Metabolic profile of healthy, normal-weight adults with low satiety responsiveness Open
The aim of this study was to characterize the metabolic profile of healthy, normal-weight adults presenting with low satiety responsiveness. Individuals were categorized with low or high satiety responsiveness (LSR and HSR, respectively) b…
View article: Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial
Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial Open
Purpose Dietary nitrate supplementation increases nitric oxide (NO) bioavailability and reduces blood pressure (BP). Inter-individual differences in these responses are suspected but have not been investigated using robust designs, e.g., r…
View article: Effects of incorporating green leafy vegetables with meals on starch and lipid digestibility under simulated gastrointestinal digestion
Effects of incorporating green leafy vegetables with meals on starch and lipid digestibility under simulated gastrointestinal digestion Open
View article: Beyond Traditional Body Composition Metrics: Load-Capacity Indices Emerge as Predictors of Cardiometabolic Outcomes—A Systematic Review and Meta-Analysis
Beyond Traditional Body Composition Metrics: Load-Capacity Indices Emerge as Predictors of Cardiometabolic Outcomes—A Systematic Review and Meta-Analysis Open
View article: Effectiveness and feasibility of a theory-informed intervention to improve Mediterranean diet adherence, physical activity and cognition in older adults at risk of dementia: the MedEx-UK randomised controlled trial
Effectiveness and feasibility of a theory-informed intervention to improve Mediterranean diet adherence, physical activity and cognition in older adults at risk of dementia: the MedEx-UK randomised controlled trial Open
View article: Foods, dietary patterns, and risk of vascular dementia: a systematic review
Foods, dietary patterns, and risk of vascular dementia: a systematic review Open
A healthy diet could lower VaD risk. However, evidence is characterised by a limited number of studies for specific dietary exposures. Further research is needed to inform personalised and population-based approaches to lower VaD risk.
View article: Inter-individual differences in the blood pressure lowering effects of dietary nitrate: A randomised double-blind placebo-controlled replicate crossover trial
Inter-individual differences in the blood pressure lowering effects of dietary nitrate: A randomised double-blind placebo-controlled replicate crossover trial Open
Purpose Dietary nitrate supplementation increases nitric oxide (NO) bioavailability and reduces blood pressure (BP). Inter-individual differences in these responses are suspected but have not been investigated using robust designs, e.g., r…
View article: Models for Predicting Dementia Risk in Low‐ and Middle‐Income Countries
Models for Predicting Dementia Risk in Low‐ and Middle‐Income Countries Open
Background Most people with dementia reside in low‐ and middle‐income countries (LMICs) where resources, research, services, and support are often very limited. Research into dementia risk prediction is scarce in LMIC settings, and those p…
View article: Editorial: Dietary nitrate: friend or foe
Editorial: Dietary nitrate: friend or foe Open
View article: Exploring the association between sarcopenic obesity and cardiovascular risk: a summary of findings from longitudinal studies and potential mechanisms
Exploring the association between sarcopenic obesity and cardiovascular risk: a summary of findings from longitudinal studies and potential mechanisms Open
It is estimated that more than one-tenth of adults aged ≥60 years are now classified as having sarcopenic obesity (SO), a clinical condition characterised by the concurrent presence of sarcopenia (low muscle mass and weakness) and obesity …
View article: Disease-Specific Risk Models for Predicting Dementia: An Umbrella Review
Disease-Specific Risk Models for Predicting Dementia: An Umbrella Review Open
Dementia is a leading cause of disability and death globally. Individuals with diseases such as cardiovascular, cardiometabolic and cerebrovascular disease are often at increased dementia risk. However, while numerous models have been deve…
View article: Nitrate and nitrite bioavailability in plasma and saliva: Their association with blood pressure — A systematic review and meta-analysis
Nitrate and nitrite bioavailability in plasma and saliva: Their association with blood pressure — A systematic review and meta-analysis Open
In this study, we conducted a systematic review and meta-analysis to determine plasma and salivary nitrate (NO3-) and nitrite (NO2-) concentrations under resting and fasting conditions in differe…
View article: Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment
Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment Open
PYY and GLP-1 appeared to influence appetite control in PD patients and their roles merit further investigation.
View article: Dementia risk prediction modelling in low- and middle-income countries: current state of evidence
Dementia risk prediction modelling in low- and middle-income countries: current state of evidence Open
Dementia is a leading cause of death and disability with over 60% of cases residing in low- and middle-income countries (LMICs). Therefore, new strategies to mitigate risk are urgently needed. However, despite the high burden of disease as…
View article: Knowledge and beliefs about dietary inorganic nitrate in a representative sample of adults from the United Kingdom
Knowledge and beliefs about dietary inorganic nitrate in a representative sample of adults from the United Kingdom Open
Objective Evaluate knowledge and beliefs about dietary nitrate among United Kingdom (UK)-based adults. Design An online questionnaire was administered to evaluate knowledge/beliefs about dietary nitrate. Overall knowledge of dietary nitrat…
View article: Improving Body Composition Analysis in Oncology: Do Measures From Multicompartment, 2C and CT Agree? Implications for Monitoring Sarcopenia Risk
Improving Body Composition Analysis in Oncology: Do Measures From Multicompartment, 2C and CT Agree? Implications for Monitoring Sarcopenia Risk Open
View article: Interindividual Differences in the Blood Pressure Lowering Effects of Dietary Nitrate: A Replicate Crossover Trial
Interindividual Differences in the Blood Pressure Lowering Effects of Dietary Nitrate: A Replicate Crossover Trial Open
Objectives: Dietary nitrate supplementation increases nitric oxide (NO) bioavailability and reduces blood pressure (BP). Individual differences in these responses are suspected but have not yet been investigated using robust designs, e.g.,…
View article: Feasibility of two levels of protein intake in patients with colorectal cancer: findings from the Protein Recommendation to Increase Muscle (PRIMe) randomized controlled pilot trial
Feasibility of two levels of protein intake in patients with colorectal cancer: findings from the Protein Recommendation to Increase Muscle (PRIMe) randomized controlled pilot trial Open
Individualized nutrition counselling positively impacted protein intake. However, 2.0 g/kg/day was not attainable using our approach in this population, and group contamination occurred. Increased protein intake suggested positive effects …
View article: What’s new in dementia risk prediction modelling? An updated systematic review
What’s new in dementia risk prediction modelling? An updated systematic review Open
Introduction Identifying individuals at high risk of dementia is critical to optimized clinical care, formulating effective preventative strategies, and determining eligibility for clinical trials. Since our previous systematic reviews in …
View article: Population attributable fractions of modifiable risk factors for dementia: a systematic review and meta-analysis
Population attributable fractions of modifiable risk factors for dementia: a systematic review and meta-analysis Open
UK Research and Innovation (Medical Research Council).