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View article: Transcriptional Regulation of CYP2E1: Promoter Methylation in In Vitro Models and Human Liver Disease Samples
Transcriptional Regulation of CYP2E1: Promoter Methylation in In Vitro Models and Human Liver Disease Samples Open
Background/Objectives: DNA methylation is a critical epigenetic mechanism involved in gene expression regulation. This study examines promoter methylation of CYP2E1 in healthy liver, intestinal mucosa, as well as pathological liver samples…
View article: An Inadequate Blood Supply Is a Risk Factor of Anastomotic Biliary Strictures After Liver Transplantation—A Single-Center Study
An Inadequate Blood Supply Is a Risk Factor of Anastomotic Biliary Strictures After Liver Transplantation—A Single-Center Study Open
Background: Anastomotic biliary strictures (BSs) are among the most common complications after liver transplantation (LT), accounting for 5–15% of adult recipients after deceased-donor transplantation. For some reason, this percentage incr…
View article: A Mixture Method for Robust Detection HCV Early Diagnosis Biomarker with ML Approach and Molecular Docking
A Mixture Method for Robust Detection HCV Early Diagnosis Biomarker with ML Approach and Molecular Docking Open
Given the substantial correlation between early diagnosis and prolonged patient survival in HCV patients, it is vital to identify a reliable and accessible biomarker. The purpose of this research was to identify accurate miRNA biomarkers t…
View article: Protein Abundance of Drug Metabolizing Enzymes in Human Hepatitis C Livers
Protein Abundance of Drug Metabolizing Enzymes in Human Hepatitis C Livers Open
Hepatic drug metabolizing enzymes (DMEs), whose activity may be affected by liver diseases, are major determinants of drug pharmacokinetics. Hepatitis C liver samples in different functional states, i.e., the Child–Pugh class A (n = 30), B…
View article: Protein Abundance of Drug Transporters in Human Hepatitis C Livers
Protein Abundance of Drug Transporters in Human Hepatitis C Livers Open
Transmembrane drug transport in hepatocytes is one of the major determinants of drug pharmacokinetics. In the present study, ABC transporters (P-gp, MRP1, MRP2, MRP3, MRP4, BCRP, and BSEP) and SLC transporters (MCT1, NTCP, OAT2, OATP1B1, O…
View article: Gene Expression and Protein Abundance of Hepatic Drug Metabolizing Enzymes in Liver Pathology
Gene Expression and Protein Abundance of Hepatic Drug Metabolizing Enzymes in Liver Pathology Open
Hepatic drug metabolizing enzymes (DMEs) markedly affect drug pharmacokinetics. Because liver diseases may alter enzymatic function and in turn drug handling and clinical efficacy, we investigated DMEs expression in dependence on liver pat…
View article: Identifying Differentially Expressed MicroRNAs, Target Genes, and Key Pathways Deregulated in Patients with Liver Diseases
Identifying Differentially Expressed MicroRNAs, Target Genes, and Key Pathways Deregulated in Patients with Liver Diseases Open
Liver diseases are important causes of morbidity and mortality worldwide. The aim of this study was to identify differentially expressed microRNAs (miRNAs), target genes, and key pathways as innovative diagnostic biomarkers in liver patien…
View article: Monocarboxylate Transporter 1 (MCT1) in Liver Pathology
Monocarboxylate Transporter 1 (MCT1) in Liver Pathology Open
Membrane monocarboxylate transporter 1 (SLC16A1/MCT1) plays an important role in hepatocyte homeostasis, as well as drug handling. However, there is no available information about the impact of liver pathology on the transporter levels and…