Marion H. C. Wijering
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View article: Insights in glial cell pathology and multiple sclerosis
Insights in glial cell pathology and multiple sclerosis Open
Multiple sclerosis (MS) is a multi-factorial central nervous system disease with heterogeneity at the clinical, pathological and molecular level. In MS, different demyelinated lesion types exist, ranging from active to mixed active-inactiv…
View article: Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis
Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis Open
View article: Identification of regional astrocyte heterogeneity associated with cuprizone-induced de- and remyelination using spatial transcriptomics
Identification of regional astrocyte heterogeneity associated with cuprizone-induced de- and remyelination using spatial transcriptomics Open
The cuprizone model is a well-characterized model to study processes of demyelination and remyelination, which are known features of multiple sclerosis. Cuprizone induces oligodendrocyte loss and severe demyelination in the brain, includin…
View article: Iguratimod Ameliorates the Severity of Secondary Progressive Multiple Sclerosis in Model Mice by Directly Inhibiting IL-6 Production and Th17 Cell Migration via Mitigation of Glial Inflammation
Iguratimod Ameliorates the Severity of Secondary Progressive Multiple Sclerosis in Model Mice by Directly Inhibiting IL-6 Production and Th17 Cell Migration via Mitigation of Glial Inflammation Open
We previously reported a novel secondary progressive multiple sclerosis (SPMS) model, progressive experimental autoimmune encephalomyelitis (pEAE), in oligodendroglia-specific Cx47-inducible conditional knockout (Cx47 icKO) mice. Based on …
View article: Iguratimod Ameliorates the Severity of Secondary Progressive Multiple Sclerosis in Model Mice by Directly Inhibiting IL-6 Production and Th17 Cell Migration via Mitigation of Glial Inflammation
Iguratimod Ameliorates the Severity of Secondary Progressive Multiple Sclerosis in Model Mice by Directly Inhibiting IL-6 Production and Th17 Cell Migration via Mitigation of Glial Inflammation Open
We previously reported a novel secondary progressive multiple sclerosis (SPMS) model, progressive experimental autoimmune encephalomyelitis (pEAE), in oligodendroglia-specific Cx47-inducible conditional knockout (Cx47 icKO) mice. Based on …
View article: Transcriptomic changes in autophagy-related genes are inversely correlated with inflammation and are associated with multiple sclerosis lesion pathology
Transcriptomic changes in autophagy-related genes are inversely correlated with inflammation and are associated with multiple sclerosis lesion pathology Open
Autophagy is a lysosomal degradative pathway essential for maintaining cellular homeostasis and is also implicated in multiple aspects of both innate and adaptive immunity. Neuroinflammation, along with demyelination and axonal loss, is an…
View article: Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter
Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter Open
Multiple sclerosis (MS) is a disease of the central nervous system that is characterized by inflammation and focal areas of demyelination, ultimately resulting in axonal degradation and neuronal loss. Several lines of evidence point toward…
View article: Additional file 6 of Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter
Additional file 6 of Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter Open
Additional file 6: Table S1: Donor and sample information. Table S2: Differential gene expression analysis total tissue bulk data. Table S3: WGCNA modules. Table S4: Differential gene expression analysis between clusters (human single cell…
View article: Brain macrophages acquire distinct transcriptomes prior to demyelination in multiple sclerosis
Brain macrophages acquire distinct transcriptomes prior to demyelination in multiple sclerosis Open
Multiple sclerosis (MS) is a disease of the central nervous system (CNS) that is characterized by inflammation and focal areas of demyelination, ultimately resulting in axonal degradation and neuronal loss. Several lines of evidence point …
View article: High-Resolution Transcriptomic and Proteomic Profiling of Heterogeneity of Brain-Derived Microglia in Multiple Sclerosis
High-Resolution Transcriptomic and Proteomic Profiling of Heterogeneity of Brain-Derived Microglia in Multiple Sclerosis Open
Microglia are important for central nervous system (CNS) homeostasis and first to respond to tissue damage and perturbations. Microglia are heterogeneous cells; in case of pathology, microglia adopt a range of phenotypes with altered funct…