Explanipedia

Differential susceptibility to colonic ulceration in mice with genetic deletion of Prostaglandin E synthase Open

Masako Nakanishi, Michaël Martinez, Patrycja Sztachelski, Marion Leclerc, Daniel W. Rosenberg · 2025

Background: Prostaglandin E₂ (PGE₂) exerts pleiotropic and context-dependent effects on inflammation, cancer and maintenance of intestinal mucosal homeostasis. To further define its role in intestinal diseases, we gen…

Design of a proteolytic module for improved metabolic modeling of <i>Bacteroides caccae</i> Open

Amandine Paulay, Ghjuvan Micaelu Grimaud, Raphaël Caballero, Béatrice Laroche, Marion Leclerc , et al. · 2024

The gut microbiota plays a crucial role in health and is significantly modulated by human diets. In addition to Western diets which are rich in proteins, high-protein diets are used for specific populations or indications, mainly weight lo…

Four functional profiles for fibre and mucin metabolism in the human gut microbiome Open

Simon Labarthe, Sandra Plancade, Sébastien Raguideau, Florian Plaza Oñate, Emmanuelle Le Chatelier , et al. · 2023

Background With the emergence of metagenomic data, multiple links between the gut microbiome and the host health have been shown. Deciphering these complex interactions require evolved analysis methods focusing on the microbial ecosystem f…

Curated and harmonized gut microbiome 16S rRNA amplicon data from dietary fiber intervention studies in humans Open

Cynthia I. Rodriguez, Ali Keshavarzian, Bruce R. Hamaker, Feitong Liu, Genelle Lunken , et al. · 2023

Nanostructure-initiator mass spectrometry biometrics Open

Marion Leclerc, Benjamin P. Bowen, Trent R. Northen · 2023

Several embodiments described herein are drawn to methods of identifying an analyte on a subject's skin, methods of generating a fingerprint, methods of determining a physiological change in a subject, methods of diagnosing health status o…

Curated and harmonized gut microbiome 16S rRNA amplicon sequences, metadata, and OTU tables from dietary fiber intervention studies in humans Open

Cynthia I. Rodriguez, Ali Keshavarzian, Bruce R. Hamaker, Feitong Liu, Genell R Healey , et al. · 2023

Data associated with the Scientific Data Data Descriptor " Curated and harmonized gut microbiome 16S rRNA amplicon data from dietary fiber intervention studies in humans". Please see the Data Descriptor for an detailed description.

FiberGrowth Pipeline: A Framework Toward Predicting Fiber-Specific Growth From Human Gut Bacteroidetes Genomes Open

Bénédicte Colnet, Christian M. K. Sieber, Fanny Perraudeau, Marion Leclerc · 2021

Dietary fibers impact gut colonic health, through the production of short-chain fatty acids. A low-fiber diet has been linked to lower bacterial diversity, obesity, type 2 diabetes, and promotion of mucosal pathogens. Glycoside hydrolases …

Nitric Oxide Impacts Human Gut Microbiota Diversity and Functionalities Open

Marion Leclerc, Cassandre Bedu-Ferrari, Lucie Etienne‐Mesmin, Mahendra Mariadassou, Lucie Lebreuilly , et al. · 2021

Gut microbiota dysbiosis has been associated with inflammatory diseases. The human inflammatory response leads to an overproduction of nitric oxide (NO) in the gut.

Parasites and diet as main drivers of the Malagasy gut microbiome richness and function Open

Stanislas Mondot, Philippe Poirier, Ahmed Abou‐Bacar, Valentin Greigert, Julie Brunet , et al. · 2021

Interplay Between Exercise and Gut Microbiome in the Context of Human Health and Performance Open

Matthieu Clauss, Philippe Gérard, Alexis Mosca, Marion Leclerc · 2021

Gut microbiota and exercise have recently been shown to be interconnected. Both moderate and intense exercise are typically part of the training regimen of endurance athletes, but they exert different effects on health. Moderate exercise h…

Investigating host-microbiome interactions by droplet based microfluidics Open

Alexandra Tauzin, Mariana Rangel Pereira, Liisa van Vliet, Pierre-Yves Colin, Élisabeth Laville , et al. · 2020

Additional file 2 of Investigating host-microbiome interactions by droplet based microfluidics Open

Alexandra Tauzin, Mariana Rangel Pereira, Liisa van Vliet, Pierre-Yves Colin, Élisabeth Laville , et al. · 2020

Additional file 2. Table S3. Functional and taxonomical annotation of the metagenomic sequences.

Elevated serum ceramides are linked with obesity-associated gut dysbiosis and impaired glucose metabolism Open

Brandon D. Kayser, Edi Prifti, Marie Lhomme, Eugeni Belda, Maria Carlota Dao , et al. · 2019

Mucosal healing progression after acute colitis in mice Open

Sandra Vidal-Lletjós, Mireille Andriamihaja, Anne Blais, Marta Grauso, Patricia Lepage , et al. · 2019

This study shows that colon repair can be initiated in the context of inflamed mucosa associated with alterations of the luminal environment and highlights the longitudinal involvement of key modulators.

Investigating Host Microbiota Relationships Through Functional Metagenomics Open

Élisabeth Laville, Josette Perrier, Nada Bejar, Marc Maresca, Jérémy Esque , et al. · 2019

The human Intestinal mucus is formed by glycoproteins, the O- and N-linked glycans which constitute a crucial source of carbon for commensal gut bacteria, especially when deprived of dietary glycans of plant origin. In recent years, a doze…

Dietary Protein Intake Level Modulates Mucosal Healing and Mucosa-Adherent Microbiota in Mouse Model of Colitis Open

Sandra Vidal-Lletjós, Mireille Andriamihaja, Anne Blais, Marta Grauso, Patricia Lepage , et al. · 2019

Mucosal healing after an inflammatory flare is associated with lasting clinical remission. The aim of the present work was to evaluate the impact of the amount of dietary protein on epithelial repair after an acute inflammatory episode. C5…

Lipo‐Protein Emulsion Structure in the Diet Affects Protein Digestion Kinetics, Intestinal Mucosa Parameters and Microbiota Composition Open

Marion Oberli, Véronique Douard, Martín Beaumont, Daphné Jaoui, Fabienne Devime , et al. · 2017

Scope Food structure is a key factor controlling digestion and nutrient absorption. We test the hypothesis that protein emulsion structure in the diet may affect digestive and absorptive processes. Methods & Results Rats ( n = 40) are fed …

Structure of protein emulsion in food impacts intestinal microbiota, caecal luminal content composition and distal intestine characteristics in rats Open

Martín Beaumont, Daphné Jaoui, Véronique Douard, Damien Mat, Fanny Koeth , et al. · 2017

Scope Few studies have evaluated in vivo the impact of food structure on digestion, absorption of nutrients and on microbiota composition and metabolism. In this study we evaluated in rat the impact of two structures of protein emulsion in…

A fibrolytic potential in the human ileum mucosal microbiota revealed by functional metagenomic Open

Orlane Patrascu, Fabienne Béguet-Crespel, Ludovica Marinelli, Emmanuelle Le Chatelier, Anne‐Laure Abraham , et al. · 2017

The digestion of dietary fibers is a major function of the human intestinal microbiota. So far this function has been attributed to the microorganisms inhabiting the colon, and many studies have focused on this distal part of the gastroint…

Inferring Aggregated Functional Traits from Metagenomic Data Using Constrained Non-negative Matrix Factorization: Application to Fiber Degradation in the Human Gut Microbiota Open

Sébastien Raguideau, Sandra Plancade, Nicolas Pons, Marion Leclerc, Béatrice Laroche · 2016

Whole Genome Shotgun (WGS) metagenomics is increasingly used to study the structure and functions of complex microbial ecosystems, both from the taxonomic and functional point of view. Gene inventories of otherwise uncultured microbial com…

Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem? Open

Alexis Mosca, Marion Leclerc, Jean‐Pierre Hugot · 2016

Most of the Human diseases affecting westernized countries are associated with dysbiosis and loss of microbial diversity in the gut microbiota. The Western way of life, with a wide use of antibiotics and other environmental triggers, may r…

Respective Roles of Hematopoietic and Nonhematopoietic Nod2 on the Gut Microbiota and Mucosal Homeostasis Open

Ziad Al Nabhani, Jean‐Pierre Hugot, Nicolas Montcuquet, Karine Le Roux, Monique Dussaillant , et al. · 2016

The immune system and the gut permeability in one hand and the microbial and epithelial peptide compositions in the other hand are separate couples of interdependent parameters, both controlled by Nod2 in either the hematopoietic or nonhem…

A Constrained NMF Approach to Analyze Quantitative Metagenomic Data * *Sebastien Raguideau is funded by a phD grant of the Meta-omics and Microbial Ecosystems (MME) program of INRA. Open

Sébastien Raguideau, Béatrice Laroche, Marion Leclerc, Sandra Plancade · 2016

In this paper, we propose a new method for inferring the metabolic potential of microbial ecosystems based on gene frequencies generated from shotgun metagenomic data. Our approach is based on Non-Negative Matrix Factorization with constra…

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota Open

Sofia K. Forslund, Falk Hildebrand, Trine Nielsen, Gwen Falony, Emmanuelle Le Chatelier , et al. · 2015

Structural robustness of the gut mucosal microbiota is associated with Crohn's disease remission after surgery Open

Stanislas Mondot, Patricia Lepage, Philippe Seksik, Matthieu Allez, Xavier Tréton , et al. · 2015

ICR modifies the gut microbiome. Remission after 6 months was associated with homogenous bacterial distribution around the anastomosis. Community structure and bacterial networks highlight target species, including Faecalibacterium prausni…

Gut microbiota richness promotes its stability upon increased dietary fibre intake in healthy adults Open

Julien Tap, Jean‐Pierre Furet, Martine Bensaada, Catherine Philippe, Hubert Roth , et al. · 2015

Summary Gut microbiota richness and stability are important parameters in host–microbe symbiosis. Diet modification, notably using dietary fibres, might be a way to restore a high richness and stability in the gut microbiota. In this work,…

Identification of Metabolic Signatures Linked to Anti-Inflammatory Effects of Faecalibacterium prausnitzii Open

Sylvie Miquel, Marion Leclerc, Rebeca Martín, Florian Chain, Marion Lenoir , et al. · 2015

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified on the basis of human clinical data. The mechanisms underlying its beneficial effects are still unknown. Gnotobiotic mice harboring F. prausnitzii (A2-165)…

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