Marion Lussignol
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View article: Autophagy machinery as exploited by viruses
Autophagy machinery as exploited by viruses Open
Viruses adapt and modulate cellular pathways to allow their replication in host cells. The catabolic pathway of macroautophagy, for simplicity referred to as autophagy, is no exception. In this review, we discuss anti-viral functions of bo…
View article: Autophagic Degradation Is Involved in Cell Protection against Ricin Toxin
Autophagic Degradation Is Involved in Cell Protection against Ricin Toxin Open
Autophagy is a complex and highly regulated degradative process, which acts as a survival pathway in response to cellular stress, starvation and pathogen infection. Ricin toxin is a plant toxin produced by the castor bean and classified as…
View article: Essential role of hyperacetylated microtubules in innate immunity escape orchestrated by the EBV-encoded BHRF1 protein
Essential role of hyperacetylated microtubules in innate immunity escape orchestrated by the EBV-encoded BHRF1 protein Open
Innate immunity constitutes the first line of defense against viruses, in which mitochondria play an important role in the induction of the interferon (IFN) response. BHRF1, a multifunctional viral protein expressed during Epstein-Barr vir…
View article: Commercially Available Eye Drops Containing Trehalose Protect Against Dry Conditions via Autophagy Induction
Commercially Available Eye Drops Containing Trehalose Protect Against Dry Conditions via Autophagy Induction Open
Purpose: Evaluation of marketed eye drops with or without trehalose, a nonreducing natural osmoprotector disaccharide, in autophagy modulation and its role in cell survival during desiccation. Methods: Eye drops…
View article: Essential role of hyperacetylated microtubules in innate immunity escape orchestrated by the EBV-encoded BHRF1 protein
Essential role of hyperacetylated microtubules in innate immunity escape orchestrated by the EBV-encoded BHRF1 protein Open
Innate immunity constitutes the first line of defense against viruses, in which mitochondria play an important role in the induction of the interferon (IFN) response. BHRF1, a multifunctional viral protein expressed during Epstein-Barr vir…
View article: La mitophagie : une stratégie du virus d’Epstein-Barr pour échapper à l’immunité innée
La mitophagie : une stratégie du virus d’Epstein-Barr pour échapper à l’immunité innée Open
International audience
View article: Human Cytomegalovirus Inhibits Autophagy of Renal Tubular Epithelial Cells and Promotes Cellular Enlargement
Human Cytomegalovirus Inhibits Autophagy of Renal Tubular Epithelial Cells and Promotes Cellular Enlargement Open
Human Cytomegalovirus (HCMV) is a frequent opportunistic pathogen in immunosuppressed patients, which can be involved in kidney allograft dysfunction and rejection. In order to study the pathophysiology of HCMV renal diseases, we concentra…
View article: BHRF1, a BCL2 viral homolog, disturbs mitochondrial dynamics and stimulates mitophagy to dampen type I IFN induction
BHRF1, a BCL2 viral homolog, disturbs mitochondrial dynamics and stimulates mitophagy to dampen type I IFN induction Open
Mitochondria respond to many cellular functions and act as central hubs in innate immunity against viruses. This response is notably due to their role in the activation of interferon (IFN) signaling pathways through the activity of MAVS (m…
View article: BHRF1, a BCL2 viral homolog, disturbs mitochondrial dynamics and stimulates mitophagy to dampen type I IFN induction
BHRF1, a BCL2 viral homolog, disturbs mitochondrial dynamics and stimulates mitophagy to dampen type I IFN induction Open
Mitochondria respond to many cellular functions and act as central hubs in innate immunity against viruses. This response is notably due to their role in the activation of interferon (IFN) signaling pathways through the activity of MAVS (m…
View article: Human cytomegalovirus hijacks the autophagic machinery and LC3 homologs in order to optimize cytoplasmic envelopment of mature infectious particles
Human cytomegalovirus hijacks the autophagic machinery and LC3 homologs in order to optimize cytoplasmic envelopment of mature infectious particles Open
View article: Author Correction: The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry
Author Correction: The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry Open
View article: The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry
The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry Open
Interferons (IFNs) mediate cellular defence against viral pathogens by upregulation of IFN-stimulated genes whose products interact with viral components or alter cellular physiology to suppress viral replication1-3. Among the I…
View article: Correction for Chaumorcel et al., “The Human Cytomegalovirus Protein TRS1 Inhibits Autophagy via Its Interaction with Beclin 1”
Correction for Chaumorcel et al., “The Human Cytomegalovirus Protein TRS1 Inhibits Autophagy via Its Interaction with Beclin 1” Open
View article: 3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection
3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection Open
With more than 240 million people infected, hepatitis B virus (HBV) is a major health concern. The inability to mimic the complexity of the liver using cell lines and regular primary human hepatocyte (PHH) cultures pose significant limitat…
View article: Herpesvirus and Autophagy: “All Right, Everybody Be Cool, This Is a Robbery!”
Herpesvirus and Autophagy: “All Right, Everybody Be Cool, This Is a Robbery!” Open
Autophagy is an essential vacuolar process of the cell, leading to lysosomal degradation and recycling of proteins and organelles, which is extremely important in maintaining homeostasis. Multiple roles have been now associated with autoph…
View article: Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis
Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis Open
Significance Virion proteomics represents a powerful and unbiased approach to gain insights into the process of virus assembly and the host factors important for infection. For hepatitis C virus (HCV), it is known that infectious virions a…