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View article: Running in mice increases the expression of brain hemoglobin-related genes interacting with the GH/IGF-1 system
Running in mice increases the expression of brain hemoglobin-related genes interacting with the GH/IGF-1 system Open
The beneficial effects of exercise are partly mediated via local or systemic functions of the insulin-like growth factor-1 (IGF-1) system. As IGF-1 increases local brain hemoglobin beta (Hbb) transcripts, we hypothesized that exercise coul…
View article: Myocardial expression of somatotropic axis, adrenergic signalling, and calcium handling genes in heart failure with preserved ejection fraction and heart failure with reduced ejection fraction
Myocardial expression of somatotropic axis, adrenergic signalling, and calcium handling genes in heart failure with preserved ejection fraction and heart failure with reduced ejection fraction Open
Aims Limited data are available regarding cardiac expression of molecules involved in heart failure (HF) pathophysiology. The majority of the studies have focused on end‐stage HF with reduced ejection fraction (HFrEF) without comparison wi…
View article: Growth Hormone and Neuronal Hemoglobin in the Brain—Roles in Neuroprotection and Neurodegenerative Diseases
Growth Hormone and Neuronal Hemoglobin in the Brain—Roles in Neuroprotection and Neurodegenerative Diseases Open
In recent years, evidence for hemoglobin (Hb) synthesis in both animal and human brains has been accumulating. While circulating Hb originating from cerebral hemorrhage or other conditions is toxic, there is also substantial production of …
View article: Mode of GH administration and gene expression in the female rat brain
Mode of GH administration and gene expression in the female rat brain Open
The endogenous secretion of growth hormone (GH) is sexually dimorphic in rats with females having a more even and males a more pulsatile secretion and low trough levels. The mode of GH administration, mimicking the sexually dimorphic secre…
View article: Effects of growth hormone in the hippocampus and cortex of adult rodents
Effects of growth hormone in the hippocampus and cortex of adult rodents Open
Background and Aims: Growth hormone (GH) affects proliferation, regeneration and specific plasticity in the adult brain. We aimed to investigate new mechanisms of local and circulating GH in the brain, and to explore the effects of differe…
View article: Growth hormone increases ALAS2, the rate-limiting enzyme of Hbb in male rat hippocampus
Growth hormone increases ALAS2, the rate-limiting enzyme of Hbb in male rat hippocampus Open
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)